Food & Function, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This study uncovers that nisin A achieves excellent anti-inflammatory activity via enhancing the level of adenosine, followed by up-regulation sphingolipid signaling pathway and down-regulation purine metabolism.
Language: Английский
Future Foods, Journal Year: 2024, Volume and Issue: 9, P. 100313 - 100313
Published: Feb. 9, 2024
Natural substances present in plants called phytochemicals are essential for fostering favourable human health outcomes. These bioactive compounds support general via a variety of processes. Phytochemicals have strong antioxidant qualities that aid scavenging dangerous free radicals from the body. This activity can promote cellular by lowering oxidative stress, major contributor to ageing and onset chronic diseases. exhibit dosage-dependent effect, which either beneficial or detrimental outcome. Several vivo vitro studies been conducted strongly supports health-promoting properties diets. A diet is rich derived fruits, vegetables, nuts, legumes, whole grains has linked lower incidence lipid peroxidation, cardiovascular disorders, cancer, other illnesses. Compounds such as β-glucans echinacea stimulate immune responses, enhancing body's ability defend against infections The study expanded understanding biochemical diversity their potential applications various fields life, including food nutrition, pharmaceuticals, cosmetics, agriculture. review deals with significance varieties used enhance nutrition overall health.
Language: Английский
Citations
26
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117277 - 117277
Published: Aug. 9, 2024
Language: Английский
Citations
14
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 557 - 557
Published: Jan. 26, 2025
The Cucurbita genus comprises various species that are globally consumed and commonly used for their nutritional value but also medicinal applications. Within the can be found ficifolia Bouché, a is understudied regarding its potential food industry, as functional food, pharmaceutical source of nutraceuticals. Therefore, in this study we investigated phytochemical composition bioactivities aqueous (AF) methanolic (MF) fractions C. pulp peel hydroethanolic (HE) extracts. HPLC-DAD-MSn HPAEC-PAD analyses extracts’ revealed low content polyphenols significant sugars. Through vitro inhibition assays enzymes alpha-amylase, acetylcholinesterase (AChE), elastase, all showed, respectively, antidiabetic, neuroprotective, anti-aging activities. safety profile anti-tumoral activities were evaluated cell models (Caco-2, HaCaT, HepG2, RAW 264.7), results showed obtained from extract induce no/low cytotoxicity, while fraction induced cytotoxicity lines. At non-cytotoxic concentrations, both extracts significantly inhibited nitric oxide (NO) production lipopolysaccharide (LPS)-stimulated 264.7 cells, revealing anti-inflammatory activity. Flow cytometry analysis increased basal levels glutathione (GSH) Caco-2 not inducing oxidative stress, antioxidant dietary agents. However, MF HE stress it reactive oxygen (ROS) lipid peroxidation. AF cycle arrest G0/G1 phase, other S phase. In conclusion, fruit presents nutraceuticals, waste products valorized by cosmeceutical industries sources bioactive molecules.
Language: Английский
Citations
0
The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(8)
Published: April 17, 2025
ABSTRACT Calycosin (CA), a bioactive isoflavone derived from Astragali Radix , has garnered interest in food sciences and pharmacology due to its potential antioxidant anti‐inflammatory properties. Our previous studies found that CA induced host defense peptide production porcine IPEC‐J2 cells alleviated hydrogen peroxide‐induced cellular oxidative damage. However, it is still unknown whether can protect against pathogenic microorganisms or toxins cause intestinal cell In this study, we aimed investigate the protective effects of LPS‐induced Using develop damage model, LPS exposure caused significant morphological apoptosis. pretreatment with effectively attenuated these adverse effects. Mechanistically, stress by reducing reactive oxygen species, malondialdehyde, 8‐hydroxy‐2'‐deoxyguanine carbonyl production, while enhancing enzyme activities gene expression. Furthermore, restored decrease nuclear erythroid 2‐related factor 2 (Nrf2) expression, Nrf2 silencing abolished CA, indicating action mediated through pathway. Additionally, suppressed inflammation downregulating inflammation‐related expression inhibiting (NF)‐κB Collectively, our findings demonstrate protects mitigating via NF‐κB pathways. These results suggest be developed as feed additive prevent injury animals, warranting further investigation vivo.
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104943 - 104943
Published: Aug. 16, 2024
Gastrointestinal diseases are associated with increased oxidative stress and inflammation. Pigmented cereal polyphenols believed to have therapeutic potential. However, the impact of digestion on their bioactivity has not been fully elucidated. This study investigated ability purple rice extract (PRx) barley (PBx) alleviate stress-induced intestinal epithelial cell death allergic The used a human colon adenocarcinoma (Caco-2) line simulate for 4 h using 1 mM hydrogen peroxide. To evaluate protective effects digested undigested extracts, cells were first pre-treated varying concentrations (50, 100, 200, 500 μg/ml) both extracts. A rat basophilic leukemia (RBL-2H3) was investigate extracts prevent calcium ionophore-induced histamine cytokine release. results demonstrated that phenolic prevented in Caco-2 reduced Interleukin (IL)-8 secretion. PRx showed greater cytoprotective than PBx. Both time-dependent antihistamine effect, greatest inhibitory observed after 2 treatment PRx. Additionally, significantly attenuated release several cytokines including IL-2, IL-4, IL-13, monocyte chemoattractant protein-1, interferon-gamma, tumour necrosis factor-alpha. Overall, demonstrates pigmented potential sources which may promote health
Language: Английский
Citations
3
Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: 16, P. 101165 - 101165
Published: April 15, 2024
A plethora of studies have indicated that protein or peptides derived from food sources possess potential anti-inflammatory activity. In our previous research, we discovered silkworm pupae (Bombyx mori) exhibited promising effects in mice. However, the activity (SPP) has yet to be validated at cellular level, and its underlying mechanisms remain unclear. Therefore, aim this study was explore SPP lipopolysaccharide (LPS)-induced RAW264.7 inflammation model. Our research findings demonstrated significantly reduced LPS-induced cells a dose-dependent manner, including decreased levels inflammatory mediators (NO, MCP-1, PEG2) cytokines (TNF-α, IL-6, IL-1β). Furthermore, observed significant downregulation mRNA expression iNOS COX-2 by (p < 0.05). Additionally, exerted inhibiting NF-κB/MAPK/PI3K signaling pathway. These results suggested may serve as novel functional ingredient for prevention treatment inflammation-related diseases.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1287 - 1287
Published: Oct. 24, 2024
The increasing incidence of colorectal cancer and inflammatory diseases poses a major health concern, with oxidative stress playing significant role in the onset these pathologies. Factors such as excessive consumption sugar-rich fatty foods, synthetic food additives, pesticides, alcohol, tobacco contribute to disrupt intestinal homeostasis. Functional foods arise potential tool regulate redox balance tract. Herbs (such
Language: Английский
Citations
1
Food & Function, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This study uncovers that nisin A achieves excellent anti-inflammatory activity via enhancing the level of adenosine, followed by up-regulation sphingolipid signaling pathway and down-regulation purine metabolism.
Language: Английский
Citations
0