Lipid Nanovesicles for Antioxidant Delivery in Skin: Liposomes, Ufasomes, Ethosomes, and Niosomes

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1516 - 1516

Published: Dec. 12, 2024

The skin, being the largest organ of human body, serves as primary barrier against external insults, including UV radiation, pollutants, and microbial pathogens. However, prolonged exposure to these environmental stressors can lead generation reactive oxygen species (ROS), causing oxidative stress, inflammation, ultimately, skin aging diseases. Antioxidants play a crucial role in neutralizing ROS preserving health by preventing damage. In recent years, nanotechnology has emerged powerful tool for enhancing delivery antioxidants onto skin. particular, liposomal formulations have offered unique advantages such improved stability, controlled release, enhanced penetration through barrier. This led surge research focused on developing liposomal-based antioxidant systems tailored applications. Through comprehensive analysis literature from 2019–2024 period, this review provides an overview emerging trends use developed aimed at improving health. It explores latest advancements formulation strategies, vesicle characterization, their applications delivering combat stress-induced damage other associated pathologies. A comparison various is conducted most common antioxidants. Finally, brief lipid nanovesicles used cosmeceutical industry provided.

Language: Английский

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In situ forming gels as subcutaneous delivery systems of curcumin and piperine

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

In this study an in situ forming gel for curcumin and piperine delivery is investigated as a long-lasting strategy the local treatment of inflammatory degenerative joint disease, such osteoarthritis rheumatoid arthritis. Particularly glyceryl monooleate, association with phosphatidylcholine ethanol, were employed. Different ratios between excipients tested, aim to obtain liquid form suitable subcutaneous injection, gaining semisolid consistency contact biological fluids. A formulative was conducted assess composition impact on structural properties formulations, particularly focusing injectability phase transition. Curcumin loaded, singularly or jointly, selected gels. Structural characterization, performed by X-ray scattering, revealed disordered reverse micellar phases, undergoing transition hexagonal cubic Pn3m upon hydration. vitro dialysis release demonstrated sustained both drugs over 96 h, faster case jointly loaded drugs. Mechanistic analysis water uptake studies indicated drug governed diffusion swelling/erosion lipid supramolecular structure. Furthermore, ex vivo using human skin explants suggested formulation suitability indicating that presence formed allowed double respect simple gel.

Language: Английский

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Gossypin-Loaded Ethosome Gel for Cutaneous Administration: A Preliminary Study on Melanoma Cells

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 186 - 186

Published: Feb. 5, 2025

A preformulative study was conducted to produce and characterize ethosomes for the transdermal delivery of gossypin. This plant-derived compound possesses many pharmacological properties, including antitumoral potential. Ethosome dispersions were designed as systems gossypin, employing two different production procedures. The evaluation vesicle size distribution by photon correlation spectroscopy, morphology cryogenic transmission electron microscopy, gossypin entrapment capacity, well in vitro release permeation vertical diffusion cells, enabled us select a strategy based on injection phosphatidylcholine ethanolic solution water. Indeed, vesicles prepared this method almost unilamellar measured roughly 150 nm mean diameter while displaying an capacity higher than 94%. Moreover, ethanol control improve its with respect drug. To obtain semi-solid forms suitable cutaneous administration, ethosome thickened 0.5% w/w xanthan gum, selected spreadability test. These gels then further characterized small- wide-angle X-ray scattering, their antioxidant activity demonstrated radical scavenging assay. Finally, biological studies A375 melanoma cell lines. Namely, wound healing migration assays confirmed potential effect especially when loaded ethosomal gel. promising results suggest investigation gossypin-loaded gel treatment melanoma.

Language: Английский

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Albumin-Based Hydrogel Films Covalently Cross-Linked with Oxidized Gellan with Encapsulated Curcumin for Biomedical Applications

Polymers, Journal Year: 2024, Volume and Issue: 16(12), P. 1631 - 1631

Published: June 8, 2024

Bovine serum albumin (BSA) hydrogels are non-immunogenic, low-cost, biocompatible, and biodegradable. In order to avoid toxic cross-linking agents, gellan was oxidized with NaIO4 obtain new functional groups like dialdehydes for protein-based hydrogel cross-linking. The formed dialdehyde were highlighted FT-IR NMR spectroscopy. This paper aims investigate films biomedical applications obtained by BSA (OxG) containing immobilized β-cyclodextrin–curcumin inclusion complex (β-CD–Curc) β-CD–Curc improved the bioavailability solubility of Curc prepared at a molar ratio 2:1. film’s structure morphology evaluated using spectroscopy SEM. swelling degree (Q%) values depend on hydrophilicity pH, higher pH = 7.4. Additionally, conversion index -NH2 into Schiff bases increases an increase in OxG amount. polymeric matrix provides protection Curc, is non-cytotoxic, enhances antioxidant activity. At 5.5, skin permeability release efficiency encapsulated curcumin than 7.4 because interaction free aldehyde carboxylic from amine proteins present membrane, resulting better film adhesion more efficient release.

Language: Английский

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A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Curcumin-Piperine Supplementation: A Promising Strategy for Managing Lipid Profiles and Liver Health in Nonalcoholic Fatty Liver Disease

Journal of Herbal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101006 - 101006

Published: March 1, 2025

Language: Английский

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Ethosomes as a new frontier and revolutionary approach for targeted skin cancer therapy

International Journal of Polymeric Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: May 6, 2025

Language: Английский

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Assessment of ex-vivo intestinal permeability and lymphatic uptake of curcumin and piperine-loaded nanostructured lipid carriers

German Journal of Pharmaceuticals and Biomaterials, Journal Year: 2024, Volume and Issue: 3(2), P. 19 - 24

Published: June 15, 2024

Curcumin (CUR) is a naturally occurring compound in food known for its potential pharmacological activity but faces challenges due to high metabolism. Piperine (PIP) an effective inhibitor of metabolizing enzymes, enhancing the bioavailability CUR. This work evaluated lymphatic absorption and ex-vivo intestinal permeability nanostructured lipid carriers (NLCs) containing PIP CUR (CP NLCs). The optimized formulation underwent in-vitrodrug release, permeation, uptake studies utilizing chicken (jejunum) segments. Studies were conducted under different conditions, specifically presence absence blocker Pluronic-F68 (PF68). PF68 non-ionic surfactant commonly used pharmaceutical research, it's ability inhibit uptake. In-vitro drug release profiles indicated controlled from NLCs over 24 h. study demonstrated that CP exhibited higher permeation compared Suspension Suspension). on NLCs, with without PF68, decrease permeation. However, blocker, transport via path increased significantly by 4.07-fold 6.56-fold PIP. means enhanced both results imply lipid-based NLC system shows as delivery method, improving solubility, aiding

Language: Английский

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Development and evaluation of curcumin-loaded vesicular carriers: impact of formulation variables

Pharmacia, Journal Year: 2024, Volume and Issue: 71, P. 1 - 8

Published: July 16, 2024

Vesicular carriers are a well-established approach to improving the technological and biopharmaceutical characteristics of loaded cargo. The current manuscript is focused on development evaluation in comparative aspect two types vesicles—ethosomes transfersomes with phytoconstituent curcumin. formulation variables affecting their physiochemical cytotoxic properties outlined as well. A series ethosomes based Lipoid S75 ethanol, or edge activator, were prepared using thin film hydration method subjected comprehensive by dynamic light scattering (DLS) analysis, transmission electron microscopy (TEM), entrapment efficiency evaluation, vitro release, cytotoxicity studies. Ethosomes (4% w/w) ethanol (30% v/v) showed suitable physicochemical (hydrodynamic diameter 578.6 nm, monomodal size distribution, high curcumin (78.2%)), superior antiproliferative activity compared free drug transfersomal nanocarriers.

Language: Английский

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Development and Validation of Simple Stability Indicating RP-HPLC method for Piperine Estimation in Piper nigrum , Marketed Formulations and Nanoformulation

Analytical Chemistry Letters, Journal Year: 2024, Volume and Issue: 14(2), P. 254 - 268

Published: April 11, 2024

AbstractThe objective of the current research is to develop simple, rapid, precise and sensitive RP-HPLC method for piperine estimation its application marketed Ayurvedic herbal formulations. A reversed-phase C-18 column (5 mm, 4.6 250 ZORBAX) was used achieve separation piperine. Optimal chromatographic conditions were established by using mobile phase consisting methanol water in a 75:25 ratio with flow rate 1 mL/min detection wavelength 342 nm. The developed HPLC estimate validated compliance ICH Q2 (R1) guidelines. newly demonstrated linearity range 0.5-16 μg/mL, regression coefficient R2 > 0.999. accuracy confirmed recovery ranging from 98.20% 99.42%. Precision also ensured, relative standard deviation (%RSD) less than 2%. Additionally, exhibited robustness. limit quantification found be 0.00056 μg/ml 0.0016 respectively. Moreover, degradation characteristics examined Q1A (R2) Piperine pronounced behaviour both oxidative thermal investigations. analytical technique successfully employed quantify Piper nigrum, commercially available products nanotransfersomes. Also, percent drug entrapped within Therefore, it can concluded that approach well-suited performing routine quality analysis formulations containing piperine.GRAPHICAL ABSTRACTDisplay full sizeKeywords: PiperinePiper nigrumNanotransfersomesValidationDegradation

Language: Английский

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Plant-Based Nanovesicular Gel Formulations Applied to Skin for Ameliorating the Anti-Inflammatory Efficiency

Gels, Journal Year: 2024, Volume and Issue: 10(8), P. 525 - 525

Published: Aug. 10, 2024

Inflammation is a vascular response that occurs when the immune system responds to range of stimuli including viruses, allergens, damaged cells, and toxic substances. accompanied by redness, heat, swelling, discomfort, loss function. Natural products have been shown considerable therapeutic benefits, they are increasingly being regarded as feasible alternatives for clinical preventative, diagnostic, treatment techniques. products, in contrast developed medications, not only contain wide variety structures, also display biological activities against disease states molecular targets. This makes natural appealing development field medicine. In spite progress has made application reasons, there still factors prevent them from reaching their full potential, poor solubility stability, well limited efficacy bioavailability. order address these problems, transdermal nanovesicular gel systems emerged viable way overcome hurdles encountered use products. These number significant advantages, ability provide sustained controlled release, large specific surface area, improved solubility, increased targeting capabilities effectiveness. Further data confirming safety nanovesicles–gel delivering preclinical models supplied extensive investigations conducted both vitro vivo. study provides summary previous research novel formulations through skin with particular emphasis on used inflammation.

Language: Английский

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