Experimental Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 110217 - 110217
Published: Dec. 1, 2024
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 594 - 594
Published: May 12, 2024
Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus, characterized by irreversible visual impairment resulting from microvascular abnormalities. Since the global prevalence continues to escalate, DR has emerged as prominent area research interest. The development and progression encompass complex interplay pathological physiological mechanisms, such high glucose-induced oxidative stress, immune responses, vascular endothelial dysfunction, well damage retinal neurons. Recent years have unveiled involvement genomic epigenetic factors in formation mechanisms. At present, extensive explores potential biomarkers cytokines, molecular cell therapies, antioxidant interventions, gene therapy for treatment. Notably, certain drugs, anti-VEGF agents, antioxidants, inhibitors inflammatory protein kinase C (PKC)-β inhibitors, demonstrated promising outcomes clinical trials. Within this context, review article aims introduce recent on highlight current progress field, with particular focus emerging experimental treatment strategies targeting redox signaling pathways.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3471 - 3471
Published: March 19, 2024
The relationship between diabetes mellitus and ocular complications has been extensively studied by many authors. Diabetic keratopathy already well characterized defined as a clinical entity. This review focuses on exploring corneal epithelial changes in diabetic patients, aiming to provide pragmatic overview of the existing knowledge this topic. paper systematically examines alterations structure their impact patients. Advanced imaging techniques are also discussed for role precise characterization improved diagnostics. Additionally, explores mechanisms behind diabetes, looking at factors such hyperglycemia, oxidative stress, Glycation End-Products. altered integrity barrier function susceptibility external issues is considered, addressing potential links heightened proteolytic enzyme activities delayed wound healing observed individuals. covers practical implications changes, including association with erosions, persistent defects, an increased risk dry eye syndrome
Language: Английский
Citations
7
Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1249 - 1249
Published: Oct. 16, 2024
Cataracts, a leading cause of blindness worldwide, are closely linked to oxidative stress-induced damage lens epithelial cells (LECs). Key factors contributing cataract formation include aging, arterial hypertension, and diabetes mellitus. Given the high global prevalence cataracts, burden cataract-related visual impairment is substantial, highlighting need for pharmacological strategies supplement surgical interventions. Understanding molecular pathways involved in stress during development may offer valuable insights designing novel therapeutic approaches. This review explores role formation, focusing on critical mechanisms, such as mitochondrial dysfunction, endoplasmic reticulum stress, loss gap junctions, various cell death LECs. Additionally, we discuss emerging potential targeting options, including antioxidant-based treatments.
Language: Английский
Citations
4
The Ocular Surface, Journal Year: 2025, Volume and Issue: 37, P. 68 - 79
Published: Feb. 27, 2025
Language: Английский
Citations
0
Experimental Eye Research, Journal Year: 2025, Volume and Issue: 255, P. 110384 - 110384
Published: April 9, 2025
Language: Английский
Citations
0
Acta Ophthalmologica, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Abstract Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder significantly impacts patients' quality of life, with prevalence rates ranging from 5% to 50% higher incidence in women. DED involves tear film instability, inflammation neurosensory abnormalities, making its management challenging due diverse underlying mechanisms. Conventional treatments typically focus on symptom relief, but new approaches targeting disease's pathogenesis are emerging. Alpha‐lipoic acid (ALA) gaining attention for potential treating OSD DED. ALA acts as potent antioxidant, neutralizing reactive oxygen species. It protects cell membranes by interacting vitamin C glutathione, potentially recycling E. Its antioxidative properties particularly relevant meibomian gland dysfunction, condition implicated By scavenging free radicals modulating redox status glands, can reduce oxidative damage, preserve glandular function decrease inflammation. In diabetic patients DED, administration has been found improve parameters, corneal defects, enhance antioxidant prevent retinopathy keratopathy. therapeutic effects especially polyneuropathy other neuropathies, primarily anti‐inflammatory metal‐chelating properties. summary, holds promise agent could be promising treatment option keratopathy, although further research needed confirm efficacy.
Language: Английский
Citations
0
Translational research, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0
Diabetologia, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Diabetic peripheral neuropathy is a debilitating microvascular complication of diabetes mellitus, with limited disease-modifying therapies to date. This study aimed assess the effect metformin on corneal sub-basal nerve plexus as outcome measure in people type 2 diabetes. A cohort 36 participants receiving therapy were recruited and underwent clinical assessment, confocal microscopy conduction studies. Concurrently, not selected disease controls matched for age, sex, duration, BMI, eGFR, HbA1c, use other oral glucose-lowering agents used treatment metabolic syndrome. Additionally, 25 healthy control assessed age sex. Medical record data over previous 20 years analysed prior current all Participants had higher fibre density (p=0.020), length (p=0.020) fractal dimension (p=0.003) compared those therapy. The inferior whorl dendritic cell was significantly lower group non-metformin (p=0.043). Metformin associated superior parameters neuroimmune tone plexus. provides further evidence that may be neuroprotective diabetic neuropathy.
Language: Английский
Citations
0
Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(4), P. 15 - 15
Published: April 7, 2025
This study aimed to explore the relationship between corneal nerve degeneration and elevated dendritic cells (DCs) in diabetic keratopathy. Corneas from healthy mice were analyzed using single-cell RNA sequencing. Corneal density DC T-cell infiltration quantified through whole-mount staining. Freshly isolated mouse trigeminal ganglion (TG) neurons co-cultured with immature DCs, mature activated CD8+ T cells, CD4+CD25- cells. TG neurite outgrowth was assessed identify potential effector driving degeneration. In addition, interferon-gamma (IFN-γ) blocking antibodies used evaluate their effects on mice. Compared age-matched mice, exhibited a significant reduction sensitivity, along increased of CD4+ vitro co-culture experiments revealed that rather than DCs significantly inhibited outgrowth. Among cytokines, IFN-γ corneas impaired induced degeneration, whereas IL-4 IL-17 had no such effect. Blocking alleviated T-cell-induced inhibition but not or contribute process partially mediated by IFN-γ.
Language: Английский
Citations
0
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(5), P. 1754 - 1754
Published: Feb. 21, 2024
Diabetic keratopathy (DK) is a common ocular complication of diabetes, characterized by alteration the normal wound-healing mechanism, reduction epithelial hemidesmosomes, disruption basement membrane, impaired barrier function, reduced corneal sensitivity, ulcers, and edema. The limited number clinical studies do not allow full characterization pathophysiology DK and, until now, effective therapeutic approaches have been available. However, in recent years, neuropeptides gained great attention for their biochemical characteristics potential. This review focuses on role vasoactive intestinal peptide (VIP) pituitary adenylate cyclase-activating polypeptide (PACAP) eye particular, cornea, physiological conditions, or during DK, providing an overview this diabetes mellitus complication.
Language: Английский
Citations
2