Mitigative and neuroprotective effects of Lavandula angustifolia essential oil on serotonin syndrome-induced neurotoxicity in male albino rats

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Feb. 2, 2025

The term serotonin syndrome (SS) is a potentially life-threatening devastating condition triggered by the excessive accumulation of serotonin, often due to an overdose or concurrent use multiple serotonergic drugs. Lavandula angustifolia (lavender), known plant from Lamiaceae family, very rich in essential oils, minerals, and tannins. This study aimed elucidate detrimental effects SS on brain evaluate neuroprotective potential L. oil. Male rats were randomly divided into following groups: control (Group 1); angustifolia-treated 2); ondansetron-treated high-dose 3); sertraline-treated 4); low-dose ondansetron + 5); 6); sertraline 7); 8). Neurotransmitter levels, dopamine metabolites, expressed cytokines quantified. Additionally, histological assessment hippocampus was performed. results revealed significant disruptions neurotransmitter amino acid levels within across treated groups. Notably, group presented pronounced increases 5-HIAA, proinflammatory cytokines, resulting neurotoxicity alterations hippocampus. Conversely, treatment with significantly attenuated these neurotoxic effects. findings suggest that confers neuroprotection against deleterious SS, particularly counteracting impact combined 5-HT3 receptor antagonists reuptake inhibitors These highlight as natural therapeutic agent for mitigating SS-induced neurotoxicity.

Language: Английский

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Linalool and Geraniol Defend Neurons from Oxidative Stress, Inflammation, and Iron Accumulation in In Vitro Parkinson’s Models

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 917 - 917

Published: July 29, 2024

Parkinson's disease is one of the most prevalent neurological disorders affecting millions people worldwide. There a growing demand for novel and natural substances as complementary therapies. Essential oils their various compounds are highly investigated plant-based products potential treatment options common human diseases, such microbial infections, chronic neurodegenerative disorders. The present study focuses on beneficial effects linalool geraniol, major lavender (

Language: Английский

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Carvacrol Essential Oil as a Neuroprotective Agent: A Review of the Study Designs and Recent Advances

Molecules, Journal Year: 2024, Volume and Issue: 30(1), P. 104 - 104

Published: Dec. 30, 2024

Neurodegenerative diseases were mostly perceived as of ageing populations, but now-a-days, these pose a threat to populations all age groups despite significant improvements in quality life. Almost essential oils (EOs) have been reported some neuroprotective abilities and used supplements for good mental health over the centuries. This review highlights therapeutic potential one such monoterpene phenolic EO, carvacrol (CV), that has be main intervention neurodegenerative disorders. Three libraries, Google Scholar, PubMed, ScienceDirect, explored research studies related roles CV. All articles from libraries sorted out, with first article tracing back 2009, latest was published 2024. The positive effects CV treatment Alzheimer’s Parkinson’s Diseases, multiple sclerosis, ischemia, behavioural disorders supported evidence. not only focused on study designs pharmacological pathways taken by neuroprotection also demographics, illustrating trend certain countries preferences use vitro or vivo models studies. Our provides useful evidence about CV; however, lack observed regarding encapsulation proper dosage forms, particular nanoparticles, which could further delivery central nervous system.

Language: Английский

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A DISEASE-BASED PERSPECTIVE OF THE RELATIONSHIP BETWEEN NEUROINFLAMMATION AND IMPAIRED GLUCOSE METABOLISM

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(3), P. 132 - 136

Published: Oct. 20, 2024

Neuroinflammation is a significant contributor to the pathogenesis of several central nervous system disorders including Alzheimer's Disease, Parkinson's Huntington's and amyotrophic lateral sclerosis. immune response against or peripheral abnormalities disturbed by foreign agents, molecules, metabolic activities, various diseases. Astrocytes microglia activation are main activators neuroinflammation. The polarization changes these defender cells have some key roles in bodily metabolism as much neuronal behavior. blood-brain barrier known first brain parenchyma. disrupts integrity may cause breakdown. Glucose energy source glucose uptake achieved through barrier. Altered detrimental effects on functions disorders. Also, it has been suggested that neuroinflammation crucial metabolism. distribution vascular endothelial neurons, astrocytes, contributes transport brain. Microglia astrocyte two underlying mechanisms It’s obviously determined neuroinflammation-caused neurodegenerative diseases tightly linked with insulin resistance disrupted cerebral However, there lacking knowledge about deficiencies microglia/astrocyte polarization. Herein this review, we summarized most common neurological possible

Language: Английский

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