International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3917 - 3917
Published: April 21, 2025
Curcumin
exhibits
antioxidant,
antibacterial,
antitumor,
and
anti-inflammatory
biological
properties.
Its
dual
functionality
as
both
a
food
additive
pH-sensitive
colorant
has
led
to
extensive
applications
in
meat
products
other
systems,
thereby
garnering
significant
research
interest.
In
recent
years,
curcumin-loaded
active-intelligent
packaging
films
have
emerged
promising
innovation
due
their
multifunctional
capabilities:
not
only
do
they
prevent
microbial
contamination
extend
shelf
life,
but
also
enable
real-time
freshness
monitoring
through
visual
colorimetric
responses.
This
paper
first
delineates
the
molecular
structure
fundamental
mechanisms
of
curcumin.
Subsequently,
it
systematically
reviews
strategies
for
curcumin
incorporation
(including
encapsulation
techniques
composite
formulations)
advanced
fabrication
methodologies
developing
biodegradable
films.
Finally,
current
polymer-based
smart
systems
are
critically
analyzed,
with
prospective
directions
proposed
address
existing
technological
limitations.
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 105 - 105
Published: Feb. 2, 2025
The
topical
administration
of
in
situ
hydrogels
for
ocular
pathologies
is
a
promising
application
strategy
providing
high
effectiveness
and
patient
compliance.
Curcumin,
natural
polyphenol,
possesses
all
the
prerequisites
successful
therapy
ophthalmic
diseases,
but
unfortunately
its
physicochemical
properties
hurdle
practical
use.
Applying
composite
thermoresponsive
hydrogel
formulation
embedded
with
polymer
nanoparticles
potent
to
overcome
identified
drawbacks.
In
present
work
we
prepared
uniform
spherical
(296.4
±
3.1
nm)
efficiently
loaded
curcumin
(EE%
82.5
2.3%)
based
on
biocompatible
biodegradable
poly-(lactic-co-glycolic
acid).
They
were
thoroughly
physicochemically
characterized
terms
FTIR,
SEM,
TGA,
DLS,
vitro
release
following
Fickian
diffusion
(45.62
2.37%),
stability
over
6
months.
Their
lack
cytotoxicity
was
demonstrated
HaCaT
cell
lines,
potential
antioxidant
protection
also
outlined,
starting
from
concentrations
as
low
0.1
µM
reaching
41%
at
5
µM.
An
(17%
w/v
poloxamer
407
0.1%
Carbopol)
suitable
optimized
respect
gelation
temperature
(31.40
0.36
°C),
gelling
time
(8.99
0.28
s)
upon
tears
dilution,
gel
erosion
(90.75
4.06%).
Upon
curcumin-loaded
nanoparticle
embedding,
appropriate
pseudoplastic
behavior
viscosity
35
°C
(2129
24
Pa∙s),
6-fold
increase
permeation,
prolonged
h.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 199 - 199
Published: Feb. 10, 2025
Aging
is
a
general
biological
process
inherent
in
all
living
organisms.
It
characterized
by
progressive
cellular
dysfunction.
For
many
years,
aging
has
been
widely
recognized
as
highly
effective
mechanism
for
suppressing
the
progression
of
malignant
neoplasms.
However,
recent
increasing
evidence
suggests
“double-edged”
role
cancer
development.
According
to
these
data,
not
only
tumor
suppressor
that
leads
cell
cycle
arrest
neoplastic
cells,
but
also
promoter
ensures
chronic
proinflammatory
and
immunosuppressive
microenvironment.
In
this
regard,
our
review,
we
discuss
data
on
destructive
senescent
cells
pathogenesis
cancer.
We
identify
first
time
correlations
between
modulation
senescence-associated
secretory
phenotype
antitumor
effects
naturally
occurring
molecules.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 807 - 807
Published: Feb. 10, 2025
Periodontal
disease
is
a
chronic
inflammatory
condition
that
destroys
the
tooth-supporting
structures
due
to
host's
immune
response
microbial
biofilms.
Traditional
periodontal
treatments,
such
as
scaling
and
root
planing,
pharmacological
interventions,
surgical
procedures,
have
significant
limitations,
including
difficulty
accessing
deep
pockets,
biofilm
recolonization,
development
of
antibiotic
resistance.
In
light
these
challenges,
natural
bioactive
compounds
derived
from
plants,
herbs,
other
sources
offer
promising
alternative
their
anti-inflammatory,
antioxidant,
antimicrobial,
tissue-regenerative
properties.
This
review
focuses
on
molecular
mechanisms
through
which
compounds,
curcumin,
resveratrol,
epigallocatechin
gallate
(EGCG),
baicalin,
carvacrol,
berberine,
essential
oils,
Gum
Arabic,
exert
therapeutic
effects
in
disease.
Bioactive
inhibit
critical
pathways
like
NF-κB,
JAK/STAT,
MAPK
while
activating
protective
Nrf2/ARE,
reducing
cytokine
production
oxidative
stress.
They
also
activity
matrix
metalloproteinases
(MMPs),
preventing
tissue
degradation
promoting
healing.
addition,
demonstrated
potential
disrupt
bacterial
biofilms
by
interfering
with
quorum
sensing,
targeting
cell
membranes,
enhancing
efficacy.Bioactive
modulate
system
shifting
balance
pro-inflammatory
anti-inflammatory
responses
efferocytosis,
helps
resolve
inflammation
supports
regeneration.
However,
despite
challenges
related
poor
bioavailability,
stability
oral
cavity,
absence
large-scale
clinical
trials
need
be
addressed.
Future
strategies
should
prioritize
advanced
delivery
systems
nanoparticles
hydrogels
enhance
bioavailability
sustain
release,
alongside
long-term
studies
assess
human
populations.
Furthermore,
combining
traditional
treatments
could
provide
synergistic
benefits
managing
aims
explore
disease,
emphasizing
action
offering
insights
into
integration
conventional
therapies
for
more
comprehensive
approach
health.
Foods,
Journal Year:
2025,
Volume and Issue:
14(4), P. 658 - 658
Published: Feb. 15, 2025
Curcuma
longa
powder
was
prepared
by
refractance
window
drying
(RWD)
and
fortified.
Fortification
of
dried
turmeric
with
folic
acid
NaFeEDTA,
along
its
characterization,
achieved.
Characterization
techniques,
such
as
FTIR,
XRD,
TGA,
DSC,
FESEM,
particle
size
analysis,
have
been
considered
to
study
the
morphological,
thermal,
crystalline
properties
resulting
fortified
turmeric.
In
vitro
digestion
studies
were
carried
out
determine
retention
nutrients
after
fortification.
The
RW-dried
exhibited
a
stable
average
PDI
values
in
range
1500-1600
nm,
for
0.25-0.29,
respectively.
enhanced
sharp
high
intensity
peaks
NaFeEDTA-fortified
powder.
affirmed
bio-accessibility
novel
at
9.77
mg/100
g
12.74
NaFeEDTA
fortification
cases,
Thus,
findings
confirmed
that
there
no
significant
influence
on
characteristics
product.
Journal of Pharmacy and Nutrition Sciences,
Journal Year:
2025,
Volume and Issue:
15, P. 1 - 14
Published: Feb. 20, 2025
Turmeric,
derived
from
the
rhizome
of
Curcuma
longa,
is
a
widely
utilized
spice.
It
characterized
by
warm
and
slightly
bitter
flavor,
often
employed
to
enhance
taste
color
curry
powders.
The
active
compound,
curcumin
has
been
subject
extensive
research
due
its
anti-inflammatory,
antioxidant,
potential
anticancer
properties,
among
others.
This
review
explores
therapeutic
curcumin,
ingredient
in
turmeric,
for
male
reproductive
health,
going
beyond
culinary
uses.
articles
used
this
narrative
were
obtained
some
search
engines
including
National
Library
Medicine
(PubMed),
Science
Alert,
Google
Scholar,
Excerta
Medical
database
(EMBASE)
Cumulated
Index
Nursing
Allied
Health
Literature
(CINAHL).
summarizes
current
scientific
evidence
regarding
curcumin's
effects
on
various
aspects
fertility,
sperm
quality.
also
highlights
anti-apoptotic
properties
how
these
contribute
benefits
addressing
issues.
Evidence
overview
existing
literature
suggests
supplementation
alleviating
infertility.
An
avenue
future
investigations
into
role
maintaining
improving
health
human
open.
Health Science Reports,
Journal Year:
2025,
Volume and Issue:
8(3)
Published: March 1, 2025
Patients
with
polycystic
ovary
syndrome
(PCOS)
commonly
have
cardiometabolic
risk
factors.
Oxidative
stress
(OS)
significantly
contributes
to
the
development
of
diseases.
Curcumin
(CUR)
exhibits
antioxidant
properties
that
aid
in
OS
regulation.
This
systematic
review
and
dose-response
meta-analysis
randomized
clinical
trials
(RCTs)
evaluated
effects
CUR
supplementation
on
factors
women
PCOS.
A
search
across
various
databases
was
implemented
identify
eligible
RCTs
published
until
January
2024.
conducted
employing
a
random-effects
model.
Eight
were
included
meta-analysis.
It
indicated
substantially
reduced
fasting
blood
sugar
(FBS)
(standardized
mean
difference
[SMD]:
-0.40
mg/dL,
95%
confidence
interval
[CI]:
-0.59,
-0.21;
p
<
0.001),
insulin
(SMD:
-0.32
µU/mL,
CI:
-0.49,
-0.14;
homeostasis
model
assessment
resistance
(HOMA-IR)
-0.36,
-0.54,
-0.19;
total
cholesterol
(TC)
-0.34
-0.61,
-0.08;
=
0.01).
In
addition,
it
increased
quantitative
sensitivity
check
index
(QUICKI)
0.37,
0.13,
0.61;
0.001)
CUR-treated
group
compared
control
group.
However,
did
not
significant
impacts
body
mass
(BMI),
weight,
serum
levels
follicle-stimulating
hormone
(FSH),
triglycerides
(TG),
dehydroepiandrosterone
(DHEA),
high-density
lipoprotein
(HDL),
testosterone,
low-density
(LDL),
luteinizing
(LH).
study
revealed
may
potential
enhance
health
by
reducing
hyperglycemia,
resistance,
TC
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
ABSTRACT
A
complete
investigation
into
phytosome‐based
formulations
and
innovative
nanotechnology
is
presented
in
this
review.
This
aims
to
improve
the
bioavailability
therapeutic
effectiveness
of
herbal
components.
Phytosomes
can
significantly
increase
solubility,
absorption,
stability
compared
standard
by
encapsulating
active
phytoconstituents
phospholipid
complexes.
unique
ability
phytosomes
overcome
limits
traditional
a
potential
game
changer
medicine.
study
highlights
different
uses
across
various
health
disorders,
such
as
neurodegenerative
illnesses,
inflammatory
conditions,
diabetes,
cardiovascular
diseases,
wound
healing.
The
review
also
discusses
treating
infectious
diseases
improving
delivery
bioactive
compounds
that
have
improved
anticancer
efficacy
antibacterial
properties.
Despite
emergence
numerous
groundbreaking
discoveries,
substantial
barriers
remain
hinder
their
widespread
application.
Challenges
must
be
addressed
include
stability,
large‐scale
manufacture,
regulatory
hurdles,
limited
clinical
translation.
examines
limitations
present
practice,
mainly
focusing
on
variability
bioavailability.
crucial
need
for
future
research
phytosomes,
engaging
researchers
emphasizing
continuous
evolution
promising
area
