An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection DOI

A Gowtham,

Chandan Chauhan,

Vikrant Rahi

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Dec. 23, 2024

Introduction Ischemic stroke (IS), a major cause of mortality and disability worldwide, remains significant healthcare challenge due to limited therapeutic options. Ferroptosis, distinct iron-dependent form regulated cell death characterized by lipid peroxidation oxidative stress, has emerged as crucial mechanism in IS pathophysiology. This review explores the role ferroptosis its potential for driving innovative strategies.

Language: Английский

Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential DOI
Thanyaporn Direksunthorn, Abdulrahman T. Ahmed,

Nakaraj Pluetrattanabha

et al.

Journal of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0
Neuroprotective effect of Schisandrin A on diabetes-associated memory impairment by alleviating inflammation and ferroptosis DOI Creative Commons

Guandi Ma,

Min Lei, Shuang Guo

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Influence of Sevoflurane Postconditioning on Hypoxic-Ischemic Brain Injury via Nrf2-Regulated Ferroptosis in Neonatal Rats DOI
Chang Li, Ziyi Wu, Hang Xue

et al.

Anesthesia & Analgesia, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

BACKGROUND: The mechanisms by which sevoflurane protects the brain from hypoxic-ischemic injury (HIBI) are unknown. Ferroptosis occurs during HIBI and is regulated nuclear factor erythroid 2-related 2 (Nrf2). This study investigated roles of Nrf2-regulated ferroptosis in postconditioning (SPC)-mediated neuroprotection HIBI. METHODS: was induced 7-day-old rats. SPC (2.5%, 30 minutes) performed immediately after HIBI, some rats were injected with ML385 (an Nrf2-inhibitor) minutes before evaluated measuring glutathione peroxidase 4 (GPx4), solute carrier family 7 member 11 (SLC7A11, also known as xCT), (GSH), cysteine, iron, malondialdehyde (MDA) levels, mitochondrial morphology. Nrf2 heme oxygenase-1 (HO-1) expression determined to explore signaling pathways involved SPC-mediated neuroprotection. Brain morphology, left/right hemisphere weight ratios, Nissl staining measured assess damage. Morris water maze conducted long-term learning memory abilities. RESULTS: alleviated HIBI-induced cysteine depletion-induced (HIBI versus SPC, xCT/β-tubulin ratio: −0.435 [95% CI, −0.727 −0.143], P = .003; Cysteine (% Sham): −29.8 −39.4 −20.2], < .001; GSH −46.5 −54.6 −38.4], .001) GPx4 inhibition-induced GPx4/β-tubulin −0.287 −0.514 −0.0603], .01). Compared group, group showed improved abilities platform crossings: −4 times −7 −1], .002; escape latency: 46 seconds 24 68], .001), reduced damage ratio cerebral hemispheres: −13.1 −15.7 −10.4], neuronal density −0.450 [−0.620 −0.280], increased HO-1 protein levels Nrf2/β-tubulin −1.89 −2.82 −0.970], HO-1/β-tubulin −1.08 −1.73 −0.442], .001). Inhibiting via partly reversed (SPC SPC+ML385, 12.4 9.73–15.1], 0.412 0.242–0.582], accompanied decreased 1.70 1.05–2.34], CONCLUSIONS: inhibits both depletion- regulating Nrf2/HO-1 protect against

Language: Английский

Citations

0
Auricular Transcutaneous Vagus Nerve Stimulation Enhances Post‐Stroke Neurological and Cognitive Recovery in Mice by Suppressing Ferroptosis Through α7 Nicotinic Acetylcholine Receptor Activation DOI Creative Commons

Hongyan Gong,

Fang Zheng,

Bochao Niu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(5)

Published: May 1, 2025

ABSTRACT Aims Ferroptosis plays a critical role in stroke pathophysiology, yet its dynamics during recovery remain unclear. This study aimed to investigate the evolution of ferroptosis throughout post‐stroke and evaluate auricular transcutaneous vagus nerve stimulation (atVNS) as therapeutic intervention, focusing on involvement α7 nicotinic acetylcholine receptor (α7nAChR)‐mediated mechanisms. Methods Using middle cerebral artery occlusion (MCAO) mouse model, we examined ferroptosis‐related protein expression (GPX4, ACSL4, TfR) iron levels across acute chronic phases. The effects atVNS were evaluated through assessment markers, neurogenesis, angiogenesis, cognitive function, neuroinflammation. α7nAChR knockout mice used receptor's atVNS‐mediated recovery. Results We observed sustained alterations markers treatment reduced progression by modulating GPX4 ACSL4 expression, enhanced neurogenesis improved recovery, These beneficial absent mice, while increased neuronal wild‐type mice. Conclusions reveals persistent demonstrates that provides comprehensive neuroprotection α7nAChR‐dependent findings establish promising noninvasive approach for highlight signaling potential target.

Language: Английский

Citations

0
Celastrol Attenuates Ferroptosis-Mediated Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury via Hippo-YAP Signaling DOI
Xing Fan,

Yi Ai,

Guo Mu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156865 - 156865

Published: May 1, 2025

Language: Английский

Citations

0
Gandouling Regulates Ferroptosis and Improves Neuroinflammation in Wilson’s Disease Through the LCN2/NLRP3 Signaling Pathway DOI Creative Commons

Yuya Wen,

Chenling Zhao, Jie Chen

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5599 - 5618

Published: Aug. 1, 2024

Purpose: Neuroinflammation is a main cause of neurological damage in Wilson's disease (WD).Ferroptosis present the WD pathological process, which also closely related to neuroinflammation.LCN2, ferroptosis-related gene WD, linked with activation NLRP3 inflammasome.Our group has previously demonstrated that Gandouling (GDL) can effectively improve neuroinflammation WD.This study aims investigate protective effect GDL on animal and cell models whether pharmacological mechanism LCN2/NLRP3 signaling pathway.Methods: Toxic milk (TX) mice HT22 cells stimulated by copper ions were selected as models.The pathology hippocampal tissues TX observed HE staining transmission electron microscopy.High-throughput sequencing analysis was conducted screen genes WD.The expression LCN2 GPX4 hippocampus detected immunohistochemical.The LCN2, NLRP3, GPX4, SLC7A11 determined Western blotting RT-qPCR.The levels Fe 2+ , inflammatory factor indicators TNF-α, IL-1β IL-6 oxidative stress 4-HNE, MAD, SOD, GSH ROS each ELISA. Results:The results showed ameliorated mitochondrial damages mice.The bioinformatics differential associated ferroptosis RT-qPCR indicated reduced enhanced SLC711 cells.The ELISA decreased factors inducer intervention ion-loaded cells.GDL ROS, 4-HNE MDA, increased SOD cells.Conclusion: anti-inflammatory antioxidant effects.LCN2 WD.GDL may alleviate inhibiting LCN2/NLPR3 pathway, thereby improving neuroinflammatory responses exerting neuroprotective effects WD.

Language: Английский

Citations

2
Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV DOI Open Access
Harpreet Kaur,

Ravi Kumar Alluri,

Kunling Wu

et al.

Published: Aug. 24, 2024

Ferroptosis is implicated in viral neuropathogenesis and may underlie HIV-associated neurocognitive impairment (NCI). Emerging data also suggest differences brain iron transport by sex. We hypothesized that circulating ferritins inhibit ferroptosis associate with function NCI people HIV (PWH) a sex-biased manner. Serum ferritin heavy-chain-1 (Fth-1), light-chain (Ftl), urinary F2-isoprostanes (uF2-isoPs, specific lipid peroxidation marker) were quantified 324 PWH (including 61 women) serial global (NPZ4) domain-specific testing. Biomarker associations test scores evaluated multivariable regression; correlations uF2-isoPs assessed. Higher Ftl Fth-1 associated less all (adjusted odds ratios 0.53, 95% Confidence Interval (95% CI) 0.36-0.79 0.66, CI 0.45-0.97, respectively). In women, higher better NPZ-4 (Ftl: adjusted beta (&beta;)=0.15, 0.02-0.29; Ftl-by-sex &beta;interaction=0.32, p=0.047) scores. Effects on performance persisted for up to 5 years. Levels of both correlated inversely women rho=-0.47, p&lt;0.001). Circulating exert sustained, neuroprotective effects PWH, possibly protecting against iron-mediated (ferroptosis). Larger studies are needed confirm the observed sex further delineate underlying mechanisms.

Language: Английский

Citations

2
Nuclear receptor 4A1 facilitates complete Freund’s adjuvant-induced inflammatory pain in rats by promoting ferroptosis in spinal glial cells DOI Creative Commons
Yifan Deng,

Ruoheng Xuan,

Zhuolin Qiu

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 125, P. 92 - 109

Published: Dec. 23, 2024

Language: Английский

Citations

2
Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV DOI Creative Commons
Harpreet Kaur,

Ravi Kumar Alluri,

Kunling Wu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1042 - 1042

Published: Aug. 28, 2024

Ferroptosis is implicated in viral neuropathogenesis and may underlie HIV-associated neurocognitive impairment (NCI). Emerging data also suggest differences brain iron transport by sex. We hypothesized that circulating ferritins inhibit ferroptosis associate with function NCI people HIV (PWH) a sex-biased manner. Serum ferritin heavy-chain-1 (FTH1), light-chain (FTL), urinary F2-isoprostanes (uF2-isoPs, specific lipid peroxidation marker) were quantified 324 PWH (including 61 women) serial global (NPZ-4) domain-specific testing. Biomarker associations test scores NCIs evaluated multivariable regression; correlations uF2-isoPs assessed. Higher FTL FTH1 levels associated less all (adjusted odds ratios 0.53, 95% confidence interval (95% CI) 0.36–0.79 0.66, CI 0.45–0.97, respectively). In women, higher better NPZ-4 (FTL adjusted beta (β) = 0.15, 0.02–0.29; FTL-by-sex βinteraction 0.32, p 0.047) scores. Effects on performance persisted for up to 5 years. Levels of both correlated inversely women (FTL: rho −0.47, < 0.001). Circulating exert sustained, neuroprotective effects PWH, possibly protecting against iron-mediated (ferroptosis). Larger studies are needed confirm the observed sex further delineate underlying mechanisms.

Language: Английский

Citations

1
Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease DOI Open Access
Bo Sun, Fei Cai, Liming Yu

et al.

Translational Pediatrics, Journal Year: 2024, Volume and Issue: 13(10), P. 1747 - 1759

Published: Oct. 1, 2024

Quercetin (QCT) is a bioflavonoid derived from vegetables and fruits that has anti-inflammatory anti-ferroptosis effects against various diseases. Previous studies have shown QCT modulates the production of cellular inflammatory factors in asthma models delays development chronic airway inflammation. However, regulatory mechanism QCT, traditional Chinese medicine, treatment not been elucidated. The aim present study to investigate whether can inhibit ferroptosis via SIRT1/Nrf2 pathway play therapeutic role asthma.

Language: Английский

Citations

1