Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES DOI Creative Commons
Jiaxin Dong, Lili Jiang, Yanpeng Liu

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a typical hepatic steatosis with metabolic dysfunction. The composite dietary antioxidant index (CDAI) measures individual capacity, and the relationship MAFLD has received little attention. Our goal to explore association of CDAI MAFLD. Participants were selected from National Health Nutrition Examination Survey (NHANES) 2013 2020. was calculated basing on six antioxidants, including zinc, selenium, carotenoids, vitamins A, C, E. Univariate regression multivariable logistic analysis conducted evaluate correlation between We performed subgroup study in various populations. A total 18,163 participants, 13,969 4,194 non-MAFLD, included. significantly negatively correlated After adjusting for all confounders (including age, gender, race, marital status, poverty ratio, education level, drinking smoking physical activity), individuals highest quartile exhibited 27% lower likelihood developing than those lowest (OR = 0.73; 95% CI [0.66, 0.81], p < 0.001). Physical activity showed that this negative significant moderate-intensity exercise population (Model 3 Q4, OR 0.72; [0.58–0.89], Additionally, changes C independently associated 3, 0.90; [0.86–0.93], found higher scores This provided new reference exploring interventions affect reduce its incidence.

Language: Английский

Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols DOI Creative Commons

Raissa Bulaty Tauil,

Paula Takano Golono,

Enzo Pereira de Lima

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

Citations

8
Inflammatory Indices and MAFLD Prevalence in Hypertensive Patients: A Large-Scale Cross-Sectional Analysis from China DOI Creative Commons
Di Shen, Xintian Cai,

Junli Hu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1623 - 1638

Published: Feb. 1, 2025

Objective: Hypertension development and progression are largely influenced by inflammation, which plays a critical role activating the immune system causing damage to vascular endothelium. Metabolic dysfunction-associated fatty liver disease (MAFLD) is also associated with chronic low-grade drives via metabolic imbalances adipose tissue dysfunction. This study investigates relationship between inflammatory indices MAFLD in hypertensive patients assesses predictive accuracy of these for MAFLD. Methods: We performed cross-sectional analysis involving 34,303 from Chinese hospital-based registry. The diagnosis was established using dysfunction criteria alongside evidence hepatic steatosis confirmed through imaging. Complete blood counts were used calculate indices, including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), systemic response index (SIRI), immune-inflammation (SII), aggregate inflammation (AISI). To assess MAFLD, multivariable logistic regression adjustments potential confounders. diagnostic performance analyzed receiver operating characteristic (ROC) curves area under curve (AUC) calculations. Results: Patients exhibited significantly elevated levels all compared those without. After adjustment, each standard deviation increase AISI, SIRI, SII 74%, 62%, 58% increased odds respectively. AUC AISI 0.659, indicating moderate accuracy. AUCs SIRI 0.626 0.619, respectively, while NLR, PLR, MLR had lower 0.593, 0.558, 0.589, Conclusion: In patients, especially show strong association their utility risk stratification within clinical settings. Further research needed evaluate effectiveness markers management Keywords: metabolic-dysfunction-associated disease, hypertension,

Language: Английский

Citations

1
The multiple mechanisms and therapeutic significance of rutin in metabolic dysfunction-associated fatty liver disease (MAFLD) DOI

Qianzhuo Wang,

Yingjuan Zhang,

Ruiling Lu

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 178, P. 106178 - 106178

Published: Aug. 15, 2024

Language: Английский

Citations

6
Curcumin: A Natural Warrior Against Inflammatory Liver Diseases DOI Open Access
Olga Napierała, Aleksandra Gostyńska, Karolina Kustrzyńska

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1373 - 1373

Published: April 18, 2025

Curcumin (CUR), a bioactive compound found in turmeric, has garnered attention for its potential anti-inflammatory properties and impact on liver health. Numerous studies suggest that CUR may be crucial mitigating inflammation. The compound’s effects are believed to attributed ability modulate various molecular pathways involved the inflammatory response. Research indicates suppress activation of cells production pro-inflammatory cytokines liver. Additionally, it been observed inhibit activity transcription factors play key role By targeting these mechanisms, help alleviate burden Moreover, CUR’s antioxidant thought contribute protective Oxidative stress is closely linked inflammation, neutralize free radicals further support action. While evidence promising, essential note more research needed fully understand precise mechanisms through which influences Nevertheless, findings could therapeutic agent managing conditions. In this review, we explore highlighting involved, as reported literature.

Language: Английский

Citations

0
Combining nutraceuticals and a mediterranean diet for managing metabolic dysfunction associated with steatotic liver disease DOI Open Access

Fong-Kuei Cheng,

Cong Chen, Fei Wang

et al.

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 25, 2025

This study was performed by Cano Contreras et al , who explored the effects of alpha-lipoic acid (ALA) and Silybum marianum (SM) supplementation combined with a mediterranean diet (MD) on metabolic dysfunction-associated steatotic liver disease (MASLD). The randomized controlled design use transient elastography provide methodological strengths, whereas focus Mexican cohort addresses critical gap in regional MASLD research. Although improvements visceral fat attenuation parameters (CAP) were observed, key markers, including transaminases lipid profiles, showed no significant changes, raising concerns about intervention's comprehensive impact. reliance CAP absence mechanistic biomarker analysis limit insights into antioxidant anti-inflammatory pathways ALA SM. Future research should explore synergistic other nutraceuticals, such as vitamin E polyphenols, include extended follow-up patient stratification to assess long-term benefits personalized therapeutic outcomes. Addressing these limitations could solidify role nutraceuticals management enable development more effective sustainable interventions.

Language: Английский

Citations

0
Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES DOI Creative Commons
Jiaxin Dong, Lili Jiang, Yanpeng Liu

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a typical hepatic steatosis with metabolic dysfunction. The composite dietary antioxidant index (CDAI) measures individual capacity, and the relationship MAFLD has received little attention. Our goal to explore association of CDAI MAFLD. Participants were selected from National Health Nutrition Examination Survey (NHANES) 2013 2020. was calculated basing on six antioxidants, including zinc, selenium, carotenoids, vitamins A, C, E. Univariate regression multivariable logistic analysis conducted evaluate correlation between We performed subgroup study in various populations. A total 18,163 participants, 13,969 4,194 non-MAFLD, included. significantly negatively correlated After adjusting for all confounders (including age, gender, race, marital status, poverty ratio, education level, drinking smoking physical activity), individuals highest quartile exhibited 27% lower likelihood developing than those lowest (OR = 0.73; 95% CI [0.66, 0.81], p < 0.001). Physical activity showed that this negative significant moderate-intensity exercise population (Model 3 Q4, OR 0.72; [0.58–0.89], Additionally, changes C independently associated 3, 0.90; [0.86–0.93], found higher scores This provided new reference exploring interventions affect reduce its incidence.

Language: Английский

Citations

2