Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 570 - 570

Published: Feb. 3, 2025

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance and beta cell dysfunction, resulting in hyperglycemia. Olive oil, cornerstone of the Mediterranean diet, has attracted considerable attention due to its potential health benefits, including reducing risk developing T2DM. This literature review aims critically examine synthesize existing research regarding impact olive oil on expression genes relevant paper also seeks provide an immunological genetic perspective signaling pathways main components extra virgin oil. Key bioactive such as oleic acid phenolic compounds, were identified modulators signaling. These compounds enhanced pathway, improved lipid metabolism, reduced oxidative stress decreasing reactive oxygen species (ROS) production. Additionally, they shown alleviate inflammation inhibiting NF-κB pathway downregulating pro-inflammatory cytokines enzymes. Furthermore, these observed mitigate endoplasmic reticulum (ER) markers, thereby protecting cells from apoptosis preserving their function. In summary, particularly constituents, been demonstrated enhance sensitivity, protect function, reduce modulating key involved processes. findings underscore oil’s therapeutic managing However, further research, well-designed human clinical trials, required fully elucidate role personalized nutrition strategies for prevention treatment

Language: Английский

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Mediterranean Treasures: Olive Varieties for Table and Olive Oil

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

This study delves into the diverse varieties of table olives and olive oils in Mediterranean Basin, renowned for its rich cultural heritage culinary traditions. Focusing on agricultural significance gastronomic versatility these products, research explores varieties, their unique flavors, nutritional profiles, historical importance. By examining regional distinctions health benefits, aims to highlight integral role oil cuisine lifestyle. Ultimately, this chapter emphasize importance managing cultivated germplasm sustainably future breeding programs. Additionally, preserving wild feral populations is crucial context global warming climate change.

Language: Английский

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Impact of fatty acids on glutamate-related gene expression in the hippocampus: Focus on lauric acid

Neuroscience Letters, Journal Year: 2025, Volume and Issue: 850, P. 138152 - 138152

Published: Feb. 1, 2025

Language: Английский

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Prunin: An Emerging Anticancer Flavonoid

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2678 - 2678

Published: March 16, 2025

Despite the substantial advances in cancer therapies, developing safe and effective treatment methodologies is critical. Natural (plant-derived compounds), such as flavonoids, might be crucial a methodology without toxicity toward healthy tissues. Prunin flavonoid with potential to used biomedical applications. has yet undergo thorough scientific research, its precise molecular mechanisms of action remain largely unexplored. This review summarizes therapeutic prunin for first time, focusing on underlying an anticancer compound. gained significant attention due antioxidant, anti-inflammatory, effects. aims unlock how functions at level exert effects, primarily modulating key cellular pathways. Furthermore, we have discussed prunin’s adjunctive therapy conventional treatments, highlighting ability strengthen responses while decreasing drug resistance. Moreover, discussion probes into innovative delivery methods, particularly nanoformulations, that address bioavailability, solubility, stability limitations optimize application. By providing comprehensive analysis properties, this stimulate further exploration using agent, thereby progressing development targeted, selective, safe, methods.

Language: Английский

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Consequences of Dietary Olive Leaf Powder Supplementation on Growth Performance, Carcass Traits, Blood Biochemical Parameters and Gut Microbiota in Broilers

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105087 - 105087

Published: March 1, 2025

This experiment examined the potential of olive leaf powder (OLP) as a natural growth enhancer in broiler feed and its influences on performance, carcass characteristics, blood parameters, intestinal bacterial count. A total 210 one-day-old Arbor Acres chicks were randomly allocated into three groups. The control group was given basal diet only, 2nd 3rd groups supplemented with 1 g OLP 2 OLP/kg diet, respectively. Each consisted seven replicates 10 unsexed each. experimental trial lasted for thirty-one days. Results showed that, OLP2 exhibited significant increase live body weight (LBW) at days 14 21 age, whereas OLP1 experienced considerable rise gain (BWG) between 29 31 age. Average daily intake (ADFI) considerably decreased during first 8-14 trial, but increased next 29-31 throughout entire duration (1-31 days). While, Feed conversion ratio (FCR) improved 15-31 trial. Carcass breast yields significantly supplementation, while abdominal fat content reduced. Blood analysis revealed enhances protein, albumin, globulin levels both groups, alanine transaminase (ALT), creatinine, cholesterol (TC), triglycerides (TG), very low-density lipoprotein (VLDL) Notably, immunity antioxidant markers improvement supplementation. Due to number beneficial bacteria such Lactobacillus rose all harmful (E. coli Clostridium) caecal samples declined. In conclusion, supplementation per kg demonstrated positive impact quality, lipid profile, immunity, status, raised contents chickens, making it promising promoter poultry production.

Language: Английский

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Oleuropein mitigates acetaminophen overdose-induced kidney injury in male rats by enhancing antioxidant defense and suppressing inflammatory and apoptotic pathways

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: March 26, 2025

Acetaminophen (APAP) is a well-known analgesic, and antipyretic drug its overdose or chronic consumption can lead to kidney damage. Oleuropein (OLE) exhibits various pharmacological properties. This study aimed determine the possible therapeutic benefits of OLE in improving APAP-induced injury. In this experimental study, 36 male Wistar rats were assigned six groups (n = 6). The initially received single dose APAP (500 mg/kg) then 1 hour later treated with at 50, 100, 200 mg/kg depending on their groups. 24 hours after treatment OLE, indicators including biochemical tests, histopathological changes, oxidative stress markers, anti-apoptotic anti-inflammatory parameters investigated renal tissue. (100 significantly decreased serum creatinine, caspase-3, tissue damage score (P < 0.05), malondialdehyde (MDA) 0.01), increased superoxide dismutase (SOD) total antioxidant capacity (TAC) 0.05) + 100 group versus group. Additionally, (200 reduced blood urea nitrogen (BUN), NF-κB, p53, Bax (p TNF-α, MDA, Bax: Bcl-2 ratio 0.001) Also, enhanced glutathione peroxidase (GPx), SOD, TAC 0.01) contrasted However, 50 didn't alter measured parameters. These findings demonstrate that could attenuate acetaminophen-induced injury through anti-oxidant, anti-inflammatory, anti-apoptosis

Language: Английский

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Oleuropein: a narrative review on its role in neurodegenerative diseases

Aging advances., Journal Year: 2025, Volume and Issue: 2(2), P. 75 - 83

Published: April 8, 2025

Olive oil, a cornerstone of the Mediterranean diet, contains trace amounts oleuropein, polyphenolic compound and its active metabolite hydroxytyrosol, which exhibit significant neuroprotective effects by reducing oxidative stress brain inflammation. These properties make them promising for managing neurodegenerative diseases such as Alzheimer’s disease. This review synthesizes current literature on chemistry, biosynthesis, activities oleuropein emphasizing their antioxidant anti-inflammatory effects. Research indicates that hydroxytyrosol is bioavailable rapidly distributed throughout body, including tissue, due to ability cross blood-brain barrier. In contrast, requires metabolic conversion bioavailability. Both compounds have been shown in preclinical animal studies mitigate stress, promote autophagy, facilitate clearance amyloid-beta aggregates. Moreover, they found alleviate mitochondrial damage dysfunction, are critical factors neurodegeneration. human studies, improved cognitive function, reduced neuroinflammation, overall health. The mechanisms underlying these include restoration redox balance modulation inflammatory pathways aging brain. Despite findings, clinical trials needed assess long-term safety efficacy settings. Understanding role neuroprotection could lead effective interventions preventing or slowing decline associated with diseases. Overall, represent compelling area study within realm antioxidants application neuroprotection.

Language: Английский

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Gellan gum-sialoglycan conjugates: a mucin mimic for alleviating inflammation in Caco-2 cells and modulating gut microbiota in the elderly

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143478 - 143478

Published: April 1, 2025

Language: Английский

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Decellularized Macroalgae as Complex Hydrophilic Structures for Skin Tissue Engineering and Drug Delivery

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 704 - 704

Published: Oct. 31, 2024

Due to their indisputable biocompatibility and abundant source, biopolymers are widely used prepare hydrogels for skin tissue engineering. Among them, cellulose is a great option this challenging application due its increased water retention capacity, mechanical strength, versatility unlimited availability. Since algae an unexploited source of cellulose, the novelty study decellularization two different species, freshly collected from Black Sea coast, using chemical surfactants (sodium dodecyl sulphate Triton X-100), characterisation resulted complex biopolymeric 3D matrices. The nature agent significantly influenced matrices porosity, while values obtained hydration degree included them in hydrogel class. Moreover, capacity retain then controllably release anti-inflammatory drug, ibuprofen, led us recommend structures as drug delivery systems. decellularized macroalgae bioadhesive cytocompatible direct contact with human keratinocytes represent support cells. Finally, it was noticed that (HaCaT cell line) adhered populated during monitoring period 14 days.

Language: Английский

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Resveratrol and Extra Virgin Olive Oil: Protective Agents Against Age-Related Disease

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4258 - 4258

Published: Dec. 10, 2024

Resveratrol and extra virgin olive oil are both recognized for their potential protective effects against age-related diseases. This overview highlights mechanisms of action, health benefits, the scientific evidence supporting roles in promoting longevity cognitive health. A literature search was conducted. Important findings related to clinical implications resveratrol EVOO were summarized. Both have complementary that may enhance anti-aging effects. promising disease-protective agents. Their antioxidant, anti-inflammatory, neuroprotective properties contribute improved outcomes longevity. Incorporating these compounds into a balanced diet offer significant benefits aging populations, reducing risk chronic Continued research is essential fully understand optimize use settings. Future should focus on investigating synergistic when consumed together, as they each other’s bioavailability efficacy health; conducting extensive trials confirm long-term various particularly individuals; further exploring molecular pathways through which exert effects, including interactions with gut microbiota metabolic pathways.

Language: Английский

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