Redox status of biomarkers in serum of dogs with hypothyroidism and its treatment with levothyroxine sodium DOI Creative Commons
Ling Zhu,

Jinge Han,

Halihaxi Bahetijiang

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Information regarding canine hypothyroidism in China remains limited, particularly the redox status of affected dogs. Therefore, objective this study was to evaluate dogs with and observe how it changed after levothyroxine replacement therapy. A total 10 healthy (control group) (treatment from Agricultural University Veterinary Teaching Hospital were included study. The assessed all 20 Thyroid profiles such as thyroxine (T4), free (fT4), thyroid-stimulating hormone (TSH) biomarkers oxidative stress, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), malondialdehyde (MDA), on day 0 days 14 45 post-levothyroxine sodium treatment hypothyroidism. Dogs had decreased levels serum T4 fT4 increased TSH. Based SOD, CAT, GSH-px, MDA, stress. Following 45-day (0.02 mg/kg orally twice daily), antioxidant parameters improved progressively: SOD 60.2 76.7 U/mL (Day 0-14) further 83.3 45); CAT 105.9 115.5 mU/mL reaching 132.9 GSH-Px 10.2 8.4 then 9.7 45), while MDA 8.2→6.8→4.4 μmol/L correspondingly. In conclusion, TSH concentrations, addition concentrations activities, indicated that there stress However, significant improvements daily) for days.

Language: Английский

Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials DOI Open Access
Bo Ma, Muttiah Barathan, Min Hwei Ng

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148

Published: March 28, 2025

Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing

Language: Английский

Citations

0
Redox status of biomarkers in serum of dogs with hypothyroidism and its treatment with levothyroxine sodium DOI Creative Commons
Ling Zhu,

Jinge Han,

Halihaxi Bahetijiang

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Information regarding canine hypothyroidism in China remains limited, particularly the redox status of affected dogs. Therefore, objective this study was to evaluate dogs with and observe how it changed after levothyroxine replacement therapy. A total 10 healthy (control group) (treatment from Agricultural University Veterinary Teaching Hospital were included study. The assessed all 20 Thyroid profiles such as thyroxine (T4), free (fT4), thyroid-stimulating hormone (TSH) biomarkers oxidative stress, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), malondialdehyde (MDA), on day 0 days 14 45 post-levothyroxine sodium treatment hypothyroidism. Dogs had decreased levels serum T4 fT4 increased TSH. Based SOD, CAT, GSH-px, MDA, stress. Following 45-day (0.02 mg/kg orally twice daily), antioxidant parameters improved progressively: SOD 60.2 76.7 U/mL (Day 0-14) further 83.3 45); CAT 105.9 115.5 mU/mL reaching 132.9 GSH-Px 10.2 8.4 then 9.7 45), while MDA 8.2→6.8→4.4 μmol/L correspondingly. In conclusion, TSH concentrations, addition concentrations activities, indicated that there stress However, significant improvements daily) for days.

Language: Английский

Citations

0