Climate-smart Halophyte: The Role of Atriplex in Future Food Security

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104869 - 104869

Published: Jan. 1, 2025

Language: Английский

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Investigation of a Thermoresponsive In Situ Hydrogel Loaded with Nanotriphala: Implications for Antioxidant, Anti-Inflammatory, and Antimicrobial Therapy in Nasal Disorders

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 106 - 106

Published: Feb. 2, 2025

Oxidative stress plays a crucial role in chronic nasal disorders, contributing to inflammation, tissue damage, and impaired mucosal function, highlighting the need for targeted therapies. Recent advancements drug delivery systems have expanded their applications treating respiratory inflammatory conditions. Among these, hydrogel-based offer prolonged release of active pharmaceutical ingredients (APIs), enhancing therapeutic efficacy reducing dosing frequency. This study initially evaluates antioxidant, anti-inflammatory, antimicrobial, cytotoxic properties Nanotriphala, followed by its incorporation into thermoresponsive situ hydrogel system, which was subsequently developed characterized as novel formulation. Nanotriphala exhibited >90% cell viability significantly reduced nitric oxide (NO) levels 40.55 µg/mL at 250 µg/mL. The key parameters, including viscosity, gelling time, pH, temperature, texture analysis, ex vivo spreadability. Stability assessed under various conditions, mutagenicity antimutagenicity were evaluated using Ames test. Results showed that gelled 34 °C, good spreadability (10.25 ± 0.28 cm), viscosity 227 22 cP, maintained pH 5.75 0.01, with optimal hardness adhesiveness suitable application. It demonstrated antimicrobial activity against E. coli, P. aeruginosa, S. aureus, epidermidis minimal bactericidal concentrations (MBCs) 32, 2, 4, 8 µg/mL, respectively, low (mutagenic index < 2) strong antimutagenic (>60%). gallic acid content 0.5796 0.0218 µg/100 mL. studies confirmed storage 4 °C. These findings suggest loaded is promising system managing oxidative related

Language: Английский

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Nigella sativa: A Comprehensive Review of Its Therapeutic Potential, Pharmacological Properties, and Clinical Applications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13410 - 13410

Published: Dec. 14, 2024

Nigella sativa (NS) is an annual herb belonging to the Ranunculaceae family, also known as black cumin or seed. This plant has been used since ancient times due its therapeutic properties and proven effective in gastrointestinal, respiratory, cardiovascular, infectious, inflammatory conditions. In this review, aim highlight effects of Arab countries “the that cures any disease”, which are provided by phytochemical compounds composition, such thymoquinone, p-cymene, α-thujene, longifolene, β-pinene, α-pinene, carvacrol. These confer antioxidant effect seeds, leading a significant decrease ROS potent anti-inflammatory effect. Also, NS seeds may have synergistic with other drugs, chemotherapeutic agents antibiotics, lead reduction dose, improved effect, could overcoming obstacles drug resistance. The studies review showed potential be agent both monotherapy adjuvant. Although there demonstrating NS, need for much more extensive research clinical trials clearly established objectives so mechanism action active substances better understood. With data far, can food production small quantities administered short periods. Further investigations understanding profile most mode administration, well clearer perspective on toxicological NS.

Language: Английский

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Thermal Treatment Inducing the Building Up of Tailor‐Made Chitosan Films Containing Gallic Acid

Journal of Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

ABSTRACT The building up of chitosan (CS)/gallic acid (GA) films was performed by casting method, thermally pre‐processing the reaction mixture at several temperatures and process times. This study focused on thermal treatment impact antioxidant activity, mechanical deformation break, water vapor diffusion, surface CS film features. It is found that energy promotes diffusion species through chains as well GA interaction with polysaccharide, producing different structural organizations. Since crosslinking degree depends received system, heterogeneous materials a low chain high free content are generated 40°C, while homogeneous covalently mostly from 50°C. availability within segregated regions favors but also polyphenol polysaccharide decreases crystallinity elastic modulus, increasing tensile strength elongation break. threshold 516 kJ regulates transition to can be tuned. discovery represents controlling synthetic factor critical design unique characteristics such those required for food packaging.

Language: Английский

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Role of gallic acid against hepatic functional and histological deteriorations in tartrazine-intoxicated rats

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: 197, P. 115303 - 115303

Published: Feb. 1, 2025

Language: Английский

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Pectin-Based Active and Smart Film Packaging: A Comprehensive Review of Recent Advancements in Antimicrobial, Antioxidant, and Smart Colorimetric Systems for Enhanced Food Preservation

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1144 - 1144

Published: March 3, 2025

This review provides a comprehensive overview of recent advancements in biodegradable active and smart packaging utilizing pectin from various origins for food applications. It critically examines the challenges limitations associated with these developments, initially focusing on structural influences properties films. Methods such as spray drying, casting, extrusion are detailed manufacturing films, highlighting their impact film characteristics. In discussing emphasizes effectiveness incorporating essential oils, plant extracts, nanoparticles to enhance mechanical strength, moisture barrier properties, resistance oxidation microbial growth. Smart is significant research area, particularly monitoring freshness. The integration natural colorants anthocyanins, betacyanins, curcumin into systems discussed ability detect spoilage meat seafood products. details specific mechanisms through which interact components environmental factors provide visible freshness indicators consumers. underscores potential technologies fulfill sustainability goals by providing eco-friendly substitutes traditional plastic packaging.

Language: Английский

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Apple and Grape Waste Pomace Fermentation and Co-Ferment Product Chemistry

Fermentation, Journal Year: 2025, Volume and Issue: 11(3), P. 126 - 126

Published: March 5, 2025

The pomace from apple and grape processing is usually treated as waste. Nowadays, has attracted increasing interest due to its potential value a nutrient source, raw ingredient for fermented products, health beneficial product. Hence, the perspective of circular economy, this study incorporated different ratios ‘Frontenac gris’ ‘McIntosh’ develop novel beverages. This provides knowledge fundamental characteristics, fermentation dynamics, final product chemistries. results indicated amounts influenced sugar content, tartaric acids, yeast nutrients in must. dynamic color changes that contributed wine’s red color, whereas mainly yellow coloration products. Apple also differently phenolic compounds, ethanol, volatile acids. Different components wine. application wine industry.

Language: Английский

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Bioactive bacterial cellulose/chitosan/sodium alginate composite film functionalized with Moringa oleifera seed extract: Antimicrobial, anticancer, and molecular docking studies

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141958 - 141958

Published: March 1, 2025

Language: Английский

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Bioactive Polyphenolic Compounds from Propolis of Tetragonula carbonaria in the Gibberagee Region, New South Wales, Australia

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 965 - 965

Published: March 12, 2025

Stingless bee propolis has emerged globally as a new source of bioactive molecules that can advance human health. However, limited research been conducted on Australian stingless propolis. This study investigated the chemical composition and biological activity produced by bees Tetragonula carbonaria from Gibberagee, distinct region New South Wales state in Australia. Using bioassay-guided fractionation, twelve compounds were isolated, including six A-ring methylated flavonoids. Nine these demonstrated strong scavenging against 2,2-diphenyl-1-picrylhydrazyl radicals, with five exhibiting greater potency than vitamin C. Chemical structures seven additional minor flavonoids determined through an intensive MS/MS data analysis. In silico screening 19 revealed all, except for gallic acid, displayed higher binding affinity to α-glucosidase antidiabetic drug, voglibose. showed Gibberagee is promising nutraceutical cosmeceutical applications owing its antioxidant properties. The unique profile C-methylated potentially provides valuable insights into botanical origin.

Language: Английский

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Gallic acid’s protective mechanisms against acrylamide-induced pulmonary injury: in vivo and in silico insights into the Nrf-2/HO-1/NFκB pathway modulation

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Acrylamide (ACR) is a toxic compound formed during the heating of tobacco and starchy foods, contributing to increased reactive oxygen species (ROS) levels significant health risks. This study evaluates protective effects gallic acid (GA), natural polyphenol with potent antioxidant anti-inflammatory properties, against ACR-induced lung injury. Fifty male rats were divided into five groups: Control, ACR, GA50 + GA100 GA100. Lung tissues analyzed biochemically, histopathologically, immunohistochemically, via immunofluorescence. GA exhibited dose-dependent by enhancing defenses through Nrf-2 (43% increase) HO-1 activation reducing lipid peroxidation markers (MDA decreased 38%). also suppressed pro-inflammatory mediators (TNF-α reduced 35%) restored modulating NF-κB pathway. Furthermore, apoptosis (Caspase-3 activity 30%) preserved tissue integrity mitigating oxidative DNA damage (8-OHdG 29%) pro-apoptotic signaling (Bax 34%). Computational analyses demonstrated GA's interaction KEAP1 protein, supporting its role in activating KEAP1-Nrf2 These findings highlight antioxidant, anti-inflammatory, anti-apoptotic suggesting therapeutic potential for protecting injury paving way future research toxicology.

Language: Английский

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