The impact of oleuropein, hydroxytyrosol, and tyrosol on cardiometabolic risk factors: a meta-analysis of randomized controlled trials

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: Jan. 19, 2025

The so-called Mediterranean diet, with olive oil as a key component, is effective in reducing cardiometabolic disease risk. Olive consumption improves blood pressure, insulin levels and resistance, supporting heart health glycemic control. Its phenolic compounds, including oleuropein (OLE), hydroxytyrosol (HT), tyrosol (TYR) are hypothesized to likely contribute these benefits. Thus, this meta-analysis evaluated the clinical effects of dietary supplementation OLE, HT, TYR on outcomes. Fourteen human intervention studies 594 participants were included. analysis using random-effects model showed that significantly reduced total cholesterol (SMD = −0.19, CI: −0.37 −0.01, p 0.04, I2 35%), triacylglycerol −0.32, −0.60 −0.03, 0.03, 73%), −0.42, −0.82 78%). Subgroup that, certain contexts, interventions may be more beneficial for BMI <30, non-Mediterranean, individuals, while compound, type intervention, duration might have differential regarding considered Overall, suggests beneficially impact some parameters, though further needed confirm findings.

Language: Английский

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Hydroxytyrosol-Infused Extra Virgin Olive Oil: A Key to Minimizing Oxidation, Boosting Antioxidant Potential, and Enhancing Physicochemical Stability During Frying

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 368 - 368

Published: March 20, 2025

The current research aims to monitor the physicochemical changes in various varieties of extra virgin olive oils (EVOOs) supplemented with exogenous polyphenolic extract from fruit, enriched hydroxytyrosol (HTyr) and its derivatives, compared numerous refined oils, sunflower oil, high oleic oil under different deep-frying conditions (170–210 °C for 3 6 h, with/without added HTyr. Acidity, K232, K270, ∆K, peroxide value (PV), anisidine (AnV), TOTOX, refractive index (RI), carotenoids, chlorophyll, antioxidant capacity using DPPH (2,2-diphenyl-1-picrylhydrazyl) approach were evaluated. results show that EVOO generally exhibit lower acidity thermal degradation particularly when deep-fried at 170 h HTyr (the best treatment). Royuela, Koroneiki, Empeltre, Manzanilla, Arbosana demonstrated K232 values (1.36, 1.67, 1.79, 1.82, 1.81, respectively). Under optimal conditions, all fell within standard limit (≤2.5), except Cornicabra. Regarding only Royuela (0.11) Manzanilla (0.22) below ≤0.22. These two also exhibited lowest ΔK (0.00). findings further revealed had TOTOX values, 20.76, 23.38, 23.85, respectively. Moreover, Koroneiki highest carotenoid ratios, 17.5 mg/kg 13.7 mg/kg, Arbosana, 1° displayed chlorophyll concentrations, 50.2, 53.7, 47.5 Furthermore, treatment indicated categories scavenging radical activity toward DPPH, even low-quality original due addition In conclusion, EVOOs °C/3 are thermally stable, exhibiting low hydrolysis, oxidation, higher potential, stable levels. not enhances health benefits EVOO, supporting EFSA claims but acts as a promising stabilizer industry, high-temperature processing over prolonged periods. This highlights potential industrial use natural alternative synthetic antioxidants, other edible practical applications food industry improve quality stability frying oils.

Language: Английский

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Natural Compounds Exert Anti‐Obesity Effects by Regulating Cytokines

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

ABSTRACT Obesity, along with its associated health risks such as hypertension, hyperlipidemia, Type 2 diabetes, stroke, metabolic syndrome, asthma, and cancer, constitutes a significant global burden, contributing substantially to morbidity mortality. Cytokines, group of secreted signaling proteins, are crucial in initiating, maintaining, resolving immune responses. Although cytokines have unique advantages regulating functions, their therapeutic application for obesity remains limited clinical practice. Natural compounds, known structural diversity low toxicity, become valuable resource drug development. Many natural compounds shown anti‐obesity effects. This review comprehensively examines the mechanisms underlying obesity, specific focus on roles cytokines, inflammatory adipokines, growth factors. Additionally, it highlights regulatory interactions between gut microbiota obesity. The critically analyzes current pharmacological interventions summarizes advanced methodologies identifying potential compounds. Finally, identifies promising that modulate cytokine activity prevent or treat assesses complementary alternative therapies.

Language: Английский

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Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1504 - 1504

Published: Nov. 22, 2024

Inflammation and apoptosis are interrelated biological processes that have a significant impact on the advancement growth of certain chronic diseases, such as cardiovascular problems, neurological conditions, osteoarthritis. Recent research has emphasized focusing these mechanisms could result in novel therapeutic approaches aim to decrease severity diseases enhance patient outcomes. Hydroxytyrosol (HT), which is well-known for its ability prevent oxidation, been identified possible candidate regulating both inflammation apoptosis. In this review, we will highlight multifaceted benefits HT agent mitigating inflammation, apoptosis, associated conditions. This review provides comprehensive overview latest vitro vivo anti-inflammatory antiapoptotic effects by it works. Based studies, strongly advised use bioactive ingredient pharmaceutical products intended well those with applications.

Language: Английский

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Assessing the Impact of Ghee, Olive Oil and Margarine on Male Rabbit Fertility and Reproductive Hormones

Journal of Animal Physiology and Animal Nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

ABSTRACT In the present investigation, impact of natural ghee, olive oil and synthetic margarine on fertility parameters male rabbits was evaluated by examining semen quality, hormones, antioxidant markers, lipid profile, liver kidney functions. Eighty were randomly allotted into four groups (20 each, replicates/group). The basal diet supplemented control group; group fed a 10% diet, ghee diet. group, quality parameters, total testosterone levels, free testosterone, luteinizing hormone (LH) enzyme levels as catalase showed significant reduction compared to other groups. At same time, they enhanced in A substantial increase triglyceride (TAG), low‐density lipoprotein (LDL) cholesterol, with decrease high‐density (HDL) observed contrasted oil‐treated strong immunoreactions androgen, FSH, LH receptors mild caspase 3 testicular tissue margarine‐treated group. Finally, histopathological examination rabbit proliferation spermatogenic cells, increased luminal spermatid seminiferous epithelium, interstitial cells normal treated Still, it severe vacuolation necrosis epithelium congestion blood vessels This study revealed that health influence is better than parameters.

Language: Английский

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