Maternal Serum Catestatin Levels in Gestational Diabetes Mellitus: A Potential Biomarker for Risk Assessment and Diagnosis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 435 - 435

Published: Jan. 11, 2025

Background/Objectives: Gestational diabetes mellitus (GDM) presents significant risks for both maternal and neonatal health, affecting fetal growth increasing the likelihood of future (DM) development in affected women. The dysregulation metabolic biomarkers, including catestatin, has been implicated GDM pathophysiology. However, clinical significance catestatin remains poorly understood, particularly context different therapeutic approaches. Methods: This observational, prospective, cross-sectional study was conducted to evaluate serum levels gestational patients healthy controls. Data were collected at a single time point during second trimester pregnancy (24 28 weeks). Participants categorized based on their glucose tolerance management strategies (diet regulation or insulin therapy). Results: Receiver Operating Characteristic (ROC) analysis demonstrated diagnostic GDM, suggesting cut-off value >9.61 ng/mL discriminating between women with without GDM. further research is needed elucidate mechanistic role its utility guiding interventions. Conclusions: Our highlights potential as biomarker risk stratification monitoring, complementing existing tools. Integrating biomarkers like into approaches may optimize health outcomes limitations our study, design sample size, underscore need multicenter studies validate findings comprehensively.

Language: Английский

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Impact of Synthesized Zero-valance Silver Nanoparticles on Acetylcholinesterase and Xanthine Oxidase: Toxicological and Environmental Implications

Case Studies in Chemical and Environmental Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 101095 - 101095

Published: Jan. 1, 2025

Language: Английский

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Pregnancy-associated plasma protein A (PAPP-A) as a first trimester serum biomarker for preeclampsia screening: a systematic review and meta-analysis

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2025, Volume and Issue: 38(1)

Published: Jan. 5, 2025

The aim of this study is to systematically examine the role pregnancy-associated plasma protein A (PAPP-A) serum biomarker in first trimester screening preeclampsia (PE).

Language: Английский

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Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 902 - 902

Published: Jan. 22, 2025

Aging and pregnancy are often considered opposites in a woman’s biological timeline. is defined by gradual decline the functional capabilities of an organism over its lifetime, while characterized presence transient placenta, which fosters cellular fitness necessary to support fetal growth. However, context preeclampsia, aging share common hallmarks, including clinical complications, altered phenotypes, heightened oxidative stress. Furthermore, women with pregnancies complicated preeclampsia tend experience age-related disorders earlier than those healthy pregnancies. Klotho, gene discovered fortuitously 1997 researchers studying mechanisms, primarily expressed kidneys but also lesser extent several other tissues, placenta. The Klotho protein membrane-bound that, upon cleavage ADAM10/17, released into circulation as soluble (sKlotho) where it plays role modulating This review focuses on involvement sKlotho development disorders, well expression recently Mytho gene, has been associated skeletal muscle atrophy.

Language: Английский

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Assessment of Cerebral Hemodynamic Changes During Roll-Over Test in Healthy Pregnant Women and Those with Mild and Severe Preeclampsia

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1182 - 1182

Published: Feb. 11, 2025

Background: Preeclampsia (PE) and eclampsia are characterized by changes in cerebral hemodynamics, which may result serious even life-threatening neurological complications. The aim of the present work was to compare hemodynamic during roll-over test women with mild severe PE. Patients methods: Healthy pregnant PE their third trimester were studied. Transcranial Doppler (TCD) measurements right middle artery (MCA) performed left lateral position 5 min after turning supine (roll-over = ROT). Besides blood flow measurements, pressure measured arm using a standard mercury sphygmomanometer. An independent gynecologist categorized preeclamptic patients into groups based on clinical laboratory results. TCD assessors unaware patient grouping while performing measurements. Results: A total 21 healthy females (mean age: 26.1 ± 5.1 yrs), 11 (28.2 6.8 18 (29 7.4 yrs) significant increase mean arterial observed all test: patients: from 106.3 16.3 113.8 15.9 mmHg; PE: 100 11.2 110 8.7 15.8 mmHg. MCA velocities significantly lower control than those MCAV control: 71.2 12.7 cm/s; 78.2 19.4 96 15.6 cm/s, p < 0.001. Turning resulted decrease groups, but differences between remained unchanged: controls: 69.5 9.1 75.7 17.5 85.7 18.4 respectively, 0.014. slight statistically insignificant pulsatility index groups. Conclusions: This is first study comparing test. Changing posture did not patients. Our results indicate that static autoregulation preserved both

Language: Английский

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Investigation of the Relationship Between IL-17, IL-27, IL-2 Blood Levels in Spontaneous Abortion and Healthy Pregnant Women

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 326 - 326

Published: Feb. 20, 2025

Background: Cytokines are essential for regulating immune cell activity during pregnancy. Research shows that CD4+ T-cells exhibit specific cytokine secretion patterns, resulting in polarized responses. This study aims to compare the gene expression levels of Th1, Th2, and Th17 cytokines women with normal pregnancies versus those a history recurrent spontaneous abortion (RSA). Methods: In this case-control study, 20 patients RSA within 24 h their last were compared pregnant no (Control Group). Cytokine IL-2, IL-17, IL-27 quantified using real-time polymerase chain reaction (RT-PCR). Results: Overall similar between groups, but both groups generally similar. However, higher IL-17 IL-2 observed healthy pregnancy group (p = 0.006 p 0.001, respectively). Elevated pregnancies, whereas lower seen shortly after miscarriage. significantly abortions < 0.001). Conclusions: may be risk factor RSA. Consistent recent studies, our findings emphasize role as crucial regulatory maintaining successful

Language: Английский

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Unveiling the placental bacterial microbiota: implications for maternal and infant health

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

The human placenta is a unique organ that forms under specific physiological conditions and plays crucial role in nutrient metabolite exchange between the mother fetus. Research on important for understanding maternal-fetal diseases. Traditionally, was considered "sterile," but advancements detection techniques have revealed presence of low level microorganisms. This discovery challenges traditional notion uterine sterile. revelation this truth marks significant breakthrough medical research, prompting more researchers to focus vital organ, placenta. Placental microbial communities may originate from oral, vaginal, intestinal microbiota expectant mothers. These microorganisms reach interface, collectively shaping placental contributing composition normal communities. Abnormal be associated with some pregnancy complications fetal developmental issues such as preterm birth, gestational hypertension, growth restriction, diabetes mellitus. Intervention strategies targeting communities, which include modulation or function, probiotics, help prevent treat related abnormal during pregnancy.

Language: Английский

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Mitochondrial Oxidative Phosphorylation Alterations in Placental Tissues from Early- and Late-Onset Preeclampsia

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3951 - 3951

Published: April 22, 2025

Preeclampsia (PE), a pregnancy complication characterized by high blood pressure and organ damage, has been suggested to be associated with mitochondrial dysfunction, although evidence remains limited. This study aimed investigate the activity of oxidative phosphorylation (OXPHOS) enzymes expression related proteins in placental tissues from women diagnosed early-onset preeclampsia (eoPE, <34 weeks gestation), late-onset (loPE, ≥34 normotensive controls. Placental samples were analyzed using immunohistochemistry, western blotting, enzymatic assays assess OXPHOS complexes. Complex I was increased 80% eoPE 56% loPE, positive correlations between normalized complex expression, gestational age at delivery (r = 0.85, p 0.01), birth weight 0.88, 0.004) loPE. Relative II loPE showed duration 0.76, 0.03) 0.77, 0.03), while controls, correlated 0.64, 0.03). Additionally, IV enzyme negatively maternal −0.69, The observed highlight metabolism as promising biomarker for predicting disease progression guiding therapeutic interventions preeclampsia. Unraveling its precise role PE pathogenesis is critical advancing diagnostic precision improving maternal-fetal outcomes.

Language: Английский

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Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 29, 2025

Liver X receptors (LXRs) are expressed in placenta and may be associated with pre-eclampsia (PE). Oxysterols act as agonists for LXRs. We recently proposed a new blood pressure-regulating circuit oxysterol 4β-hydroxycholesterol (4βHC) acting hypotensive factor via This study investigated the association between maternal plasma 4βHC, pressure (BP) indices, placental expression of LXR target genes, patient characteristics using data from Finnish Genetics Pre-Eclampsia Consortium (FINNPEC) cohort. Plasma samples 144 women PE 38 healthy pregnant controls well 44 40 control were available. In addition, genetic FinnGen project was utilized to explore associations alleles pregnancy hypertension. There no significant 4βHC BP or perinatal FINNPEC However, inversely correlated body mass index. variants LXRs FinnGen. genes APOD, SCARB1, TGM2, LPCAT3 differently normal pregnancies FINNPEC. Our results demonstrate that do not play major role regulation during pregnancy. key involved lipid metabolism pregnancies. Further research is needed understand complexities oxysterols, LXRs, their potential contributions function outcomes.

Language: Английский

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Environmental Pollution and Oxidative Stress: Health Effects During Pregnancy: A Review

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(21), P. 9884 - 9884

Published: Oct. 29, 2024

Oxidative stress is an imbalance between reactive oxygen species production and antioxidant defense that can lead to reproductive disorders poor pregnancy outcomes. Environmental pollution under climate change involved in formation may cause various dysfunctions of the system. a widespread factor affects physiology male female systems, leading high levels DNA damage infertility. Miscarriage, preeclampsia, premature birth are all linked oxidative stress. induces excesses by expanding ROS generation or overwhelming physiological responses This increases cellular damage, inflammation, development numerous diseases. Here, we present brief outline developmental roles plays during pregnancy. We also offer some insights into underlying mechanisms have been put forth, which culminate summary harmful effects environmental origin pregnancy-related complications. The current work motivate design more focused wellbeing measures order prevent promote human health anticipate unfavorable

Language: Английский

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