Luteolin as a modulator of skin aging and inflammation

BioFactors, Journal Year: 2020, Volume and Issue: 47(2), P. 170 - 180

Published: Dec. 25, 2020

Abstract Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables spices. It plays an important role defending plants, for example against UV radiation by partially absorbing UVA UVB radiation. Thus, luteolin also decrease adverse photobiological effects skin acting as a first line defense. Furthermore, anti‐oxidative anti‐inflammatory activities were described on keratinocytes fibroblasts well several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic T cells). suppress proinflammatory mediators IL‐1β, IL‐6, IL‐8, IL‐17, IL‐22, TNF‐α COX‐2) regulate various signaling pathway NF‐κB, JAK–STAT TLR pathway). In this way, modulates many inflammatory processes skin. The present review summarizes recent vitro vivo research field aging cancer, wound healing diseases, including psoriasis, contact dermatitis atopic dermatitis. conclusion, might promising molecule development topic formulations systemic agents diseases.

Language: Английский

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Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

The EPMA Journal, Journal Year: 2023, Volume and Issue: 14(1), P. 21 - 42

Published: Feb. 13, 2023

Abstract Proliferative diabetic retinopathy (PDR) the sequel of (DR), a frequent complication diabetes mellitus (DM), is leading cause blindness in working-age population. The current screening process for DR risk not sufficiently effective such that often disease undetected until irreversible damage occurs. Diabetes-associated small vessel and neuroretinal changes create vicious cycle resulting conversion into PDR with characteristic ocular attributes including excessive mitochondrial retinal cell damage, chronic inflammation, neovascularisation, reduced visual field. considered an independent predictor other severe complications as ischemic stroke. A “domino effect” highly cascading DM which early indicator impaired molecular signaling. Mitochondrial health control clinically relevant management, multi-omic tear fluid analysis can be instrumental prognosis prediction. Altered metabolic pathways bioenergetics, microvascular deficits disease, tissue remodelling are focus this article evidence-based targets predictive approach to develop diagnosis treatment algorithms tailored individual cost-effective prevention by implementing paradigm shift from reactive medicine predictive, preventive, personalized (PPPM) primary secondary care management.

Language: Английский

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Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer

Cancer Letters, Journal Year: 2021, Volume and Issue: 515, P. 36 - 48

Published: May 28, 2021

Language: Английский

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Flavonoids against the SARS-CoV-2 induced inflammatory storm

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 138, P. 111430 - 111430

Published: Feb. 26, 2021

The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated uncontrolled excessive release proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites plants, have long been studied as therapeutic interventions inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss potential role flavonoids modulation signaling pathways that are crucial for COVID-19 disease, particularly those related inflammation immunity. immunomodulatory ability flavonoids, carried out regulation mediators, inhibition endothelial activation, NLRP3 inflammasome, toll-like receptors (TLRs) or bromodomain containing protein 4 (BRD4), activation nuclear factor erythroid-derived 2-related 2 (Nrf2), might be beneficial regulating storm during SARS-CoV-2 infection. Moreover, inhibit dipeptidyl peptidase (DPP4), neutralize 3-chymotrypsin-like protease (3CLpro) affect gut microbiota maintain response, dual action angiotensin-converting enzyme (ACE-2) may potentially also applied responses induced SARS-CoV-2. Based on previously proven effects other basis newly published studies (bioinformatics, molecular docking), it reasonable assume positive changes COVID-19. This review highlights current state knowledge utility management points multiple biological processes deregulated pathology identification agents, including naturally occurring substances such represents great approach utilizable Although not clinically investigated yet, applicability against could a promising strategy broad spectrum activities.

Language: Английский

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The long and short non-coding RNAs modulating EZH2 signaling in cancer

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 2, 2022

Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding proteins. However, they participate developmental and biological processes their abnormal expression affects cancer progression. These can function as upstream mediators different signaling pathways enhancer zeste homolog 2 (EZH2) is among them. Briefly, EZH2 belongs to PRCs exert functional roles cells due its methyltransferase activity. gene via inducing H3K27me3. In the present review, our aim provide mechanistic discussion ncRNAs role regulating cancers. MiRNAs dually induce/inhibit affect downstream targets such Wnt, STAT3 EMT. Furthermore, miRNAs regulate therapy response affecting signaling. It noteworthy that reduce miRNA by binding promoter exerting Small-interfering (siRNA) short-hairpin (shRNA) synthetic, short capable reducing suppressing LncRNAs mainly targeting miRNAs. lncRNAs induce modulating expression. Circular (CircRNAs), like lncRNAs, areas discussed review focus on molecular leading clinical translation.

Language: Английский

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Phytochemicals in Cancer Treatment and Cancer Prevention—Review on Epidemiological Data and Clinical Trials

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1896 - 1896

Published: April 14, 2023

Phytochemicals are a non-nutritive substances that present in plants and contribute significantly to their flavor color. These biologically active compounds classified into five major groups, namely phenolics, carotenoids, organosulfur compounds, nitrogen-containing alkaloids, known for potential health benefits the prevention of various diseases, including cancer. The purpose this review article is explore therapeutic dietary phytochemicals, such as flavonoids, phenolic acids, phytosterols, stilbenes, cancer treatment based on epidemiological studies clinical trials. Although majority report significant advantage heightened phytochemical consumption increased serum levels these linking exposure with lower risk across most types, effects could not be replicated available In fact, many trials were withdrawn early due lack evidence and/or harm. Despite strong anticancer effect well proven efficacy multiple studies, there still great need human trials, caution regarding safety measures. This provides an overview supporting chemopreventive properties focus further research area.

Language: Английский

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Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

The EPMA Journal, Journal Year: 2021, Volume and Issue: 12(2), P. 155 - 176

Published: May 17, 2021

Abstract Cost-efficacy of currently applied treatments is an issue in overall cancer management challenging healthcare and causing tremendous economic burden to societies around the world. Consequently, complex treatment models presenting concepts predictive diagnostics followed by targeted prevention tailored personal patient profiles earn global appreciation as benefiting patient, economy, society at large. In this context, application flavonoids a spectrum compounds their nano-technologically created derivatives extensively under consideration, due multi-faceted anti-cancer effects applicable cost-effective management, primary, secondary, even tertiary prevention. This article analyzes most recently updated data focused on potent capacity promote therapeutic interprets all collected research achievements frame-work predictive, preventive, personalized (3P) medicine. Main pillars considered are: - Predictable anti-neoplastic, immune-modulating, drug-sensitizing effects; Targeted molecular pathways improve outcomes increasing sensitivity cells reversing resistance towards modalities.

Language: Английский

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Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

Cancers, Journal Year: 2021, Volume and Issue: 13(1), P. 130 - 130

Published: Jan. 3, 2021

Tumor hypoxia is described as an oxygen deprivation in malignant tissue. The hypoxic condition a consequence of imbalance between rapidly proliferating cells and vascularization that leads to lower levels tumors. Hypoxia-inducible factor 1 (HIF-1) essential transcription contributing the regulation hypoxia-associated genes. Some these genes modulate molecular cascades associated with Warburg effect its accompanying pathways and, therefore, represent promising targets for cancer treatment. Current progress development therapeutic approaches brings several inhibitors HIF-1. Flavonoids, widely occurring various plants, exert broad spectrum beneficial effects on human health, are potentially powerful tools against cancer. Recent evidences identified numerous natural flavonoids their derivatives HIF-1, critical glycolytic components cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), (PDK). Here, we discuss results most recent studies evaluating impact HIF-1 accompanied by enzymes phenotype. Besides, flavonoid metabolism via activity avenue cancer-related research. At same time, only more-in depth investigations can further elucidate mechanistic clinical connections metabolism.

Language: Английский

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Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders

Biomedicines, Journal Year: 2021, Volume and Issue: 9(2), P. 99 - 99

Published: Jan. 20, 2021

Neurodegenerative disorders, such as Parkinson's disease (PD), Alzheimer's (AD), Amyotrophic lateral sclerosis (ALS), and Huntington's (HD), are the most concerning disorders due to lack of effective therapy dramatic rise in affected cases. Although these have diverse clinical manifestations, they all share a common cellular stress response. These responses including neuroinflammation, oxidative stress, proteotoxicity, endoplasmic reticulum (ER)-stress, which combats with conditions. Environmental stress/toxicity weakened response results cell damage. Small molecules, flavonoids, could reduce gained much attention recent years. Evidence has shown potential use flavonoids several ways, antioxidants, anti-inflammatory, anti-apoptotic, yet their mechanism is still elusive. This review provides an insight into role against that prevent pathogenesis neurodegenerative disorders.

Language: Английский

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Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

ACS Combinatorial Science, Journal Year: 2020, Volume and Issue: 22(12), P. 669 - 700

Published: Oct. 23, 2020

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because the outstanding therapeutic activity multitargeting capability these compounds. However, poor solubility bioavailability compounds have limited their efficacy therapy. To circumvent this hurdle, nanocarriers been designed to improve antitumor aforementioned Nevertheless, treatment still a challenge, demanding novel strategies. It well-known that combination products gene advantageous over monotherapy. Delivery multiple agents/small interfering RNA (siRNA) potent gene-editing tool can maximize synergistic effects against tumor cells. In present review, co-delivery compounds/siRNA nanovehicles are highlighted provide backdrop for future research.

Language: Английский

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