Antibiotic Resistance: Challenges and Strategies in Combating Infections DOI Open Access

Jay Chavada,

Komal N Muneshwar,

Yash Ghulaxe

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 26, 2023

From a broader perspective, antibiotic or antimicrobial resistance is still evolving and spreading internationally. Infectious diseases have become more complex often impossible to cure, increasing morbidity mortality. Despite the failure of conventional, standard therapy, no new class antibiotics has been developed in last 20 years, which results various cutting-edge other tactics that can be used encounter these disease-causing microorganisms with resistance. In continued fight against bacterial infections, there an urgent requirement for antimicrobials. Antibiotic inevitable, pharmaceutical companies consistently show little interest funding novel research. Some methods are being as possible replacement conventional antibiotics. Combination target proteins enzymes cause resistance, systems delivery drug, physicochemical approaches, informal ways, such CRISPR-Cas system, some approaches. These approaches influence how multi-drug-resistant organisms handled human clinical settings.

Language: Английский

Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace DOI
David Chinemerem Nwobodo, Malachy Ugwu, Clement Oliseloke Anie

et al.

Journal of Clinical Laboratory Analysis, Journal Year: 2022, Volume and Issue: 36(9)

Published: Aug. 10, 2022

Abstract Background Antibiotic resistance is currently the most serious global threat to effective treatment of bacterial infections. has been established adversely affect both clinical and therapeutic outcomes, with consequences ranging from failures need for expensive safer alternative drugs cost higher rates morbidity mortality, longer hospitalization, high‐healthcare costs. The search new antibiotics other antimicrobials continues be a pressing in humanity's battle against appears inevitable, there continuous lack interest investing antibiotic research by pharmaceutical industries. This review summarized some strategies tackling bacteria. Methods To provide an overview recent research, we look at preventing and/or reviving bacteria's susceptibility already existing antibiotics. Results Substantial pieces evidence suggest that interact host immunity, leading potent indirect effects improve antibacterial activities may result more swift complete bactericidal effects. A class referred as immuno‐antibiotics targeting biochemical pathway components including inhibition SOS response hydrogen sulfide underlying networks bacteria can considered emerging combat Conclusion highlighted discussed weapons

Language: Английский

Citations

525
Sensing and Bioimaging of the Gaseous Signaling Molecule Hydrogen Sulfide by Near-Infrared Fluorescent Probes DOI

D. Amilan Jose,

Rahul Sakla,

Nancy Sharma

et al.

ACS Sensors, Journal Year: 2020, Volume and Issue: 5(11), P. 3365 - 3391

Published: Nov. 9, 2020

A fluorescent probe for the monitoring of H2S levels in living cells and organisms is highly desirable. In this regard, near-infrared (NIR) probes have emerged as a promising tool. NIR-I NIR-II many significant advantages; instance, NIR light penetrates deeper into tissue than at visible wavelengths, it causes less photodamage during biosample analysis autofluorescence, enabling higher signal-to-background ratios. Therefore, expected that having emission region are more suitable vivo imaging. Consequently, considerable increase reports new H2S-responsive appeared literature. This review highlights advances made developing aimed sensitive selective detection biological samples. Their applications real-time bioimaging cells/animals emphasized. The selection dyes designing probes, along with principles mechanisms involved sensing region, described. discussions focused on small-molecule nanomaterials-based probes.

Language: Английский

Citations

149
Hydrogen sulfide signaling in plant response to temperature stress DOI Creative Commons
Zhong‐Guang Li,

Jue-Rui Fang,

Su-Jie Bai

et al.

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: March 13, 2024

For the past 300 years, hydrogen sulfide (H 2 S) has been considered a toxic gas. Nowadays, it found to be novel signaling molecule in plants involved regulation of cellular metabolism, seed germination, plant growth, development, and response environmental stresses, including high temperature (HT) low (LT). As molecule, H S can actively synthesized degraded cytosol, chloroplasts, mitochondria cells by enzymatic non-enzymatic pathways maintain homeostasis. To date, receptors for have not found. It usually exerts physiological functions through persulfidation target proteins. In 10 gained much attention. Therefore, this review, based on that same attention, homeostasis, protein persulfidation, role HT LT stress were summarized. Also, common mechanisms S-induced tolerance updated. These involve restoration biomembrane integrity, synthesis proteins, enhancement antioxidant system methylglyoxal (MG) detoxification system, improvement water homeostasis reestablishment Ca 2+ acid-base balance. updates lay foundation further understanding acquiring temperature-stress-resistant crops develop sustainable food agriculture.

Language: Английский

Citations

24
A pyrene-based fluorescent sensor for the discrimination and estimation of hydrazine and hydrogen sulfide and its application in assessing food spoilage DOI

Vannappilakkal Sreelaya,

Vasu Drisya,

Lakshmi Chakkumkumarath

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137151 - 137151

Published: Jan. 7, 2025

Language: Английский

Citations

2
Hydrogen sulfide mechanism of action in plants; from interaction with regulatory molecules to persulfidation of proteins DOI

Shirin Mohammadbagherlou,

Elaheh Samari,

Mostafa Sagharyan

et al.

Nitric Oxide, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells DOI Creative Commons
Csaba Szabó

Cells, Journal Year: 2021, Volume and Issue: 10(2), P. 220 - 220

Published: Jan. 22, 2021

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed primary mode its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles H2S an endogenously produced mammalian gaseous transmitter. Cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) 3-mercaptopyruvate sulfurtransferase (3-MST) are currently principal H2S-generating enzymes. In contrast to inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, serves stimulator electron transport in mitochondria, by acting donor—with sulfide:quinone oxidoreductase (SQR) being immediate acceptor. The significant various cancer cells, many which exhibit high expression partial localization producing addition stimulation ATP production, endogenous cells include maintenance organization (protection against fission) DNA repair (via assembly complexes). current article overviews state-of-the-art knowledge regarding functions cells.

Language: Английский

Citations

85
Hydrogen sulfide signaling in plant adaptations to adverse conditions: molecular mechanisms DOI Creative Commons
Ángeles Aroca, Jing Zhang,

Yanjie Xie

et al.

Journal of Experimental Botany, Journal Year: 2021, Volume and Issue: 72(16), P. 5893 - 5904

Published: May 24, 2021

Hydrogen sulfide (H2S) is a signaling molecule that regulates critical processes and allows plants to adapt adverse conditions. The molecular mechanism underlying H2S action relies on its chemical reactivity, the most-well characterized persulfidation, which involves modification of protein thiol groups, resulting in formation persulfide groups. This causes change function, altering catalytic activity or intracellular location inducing important physiological effects. cannot react directly with thiols but instead can oxidized cysteine residues; therefore, H2O2 through sulfenylation required for persulfidation. A comparative study performed this review reveals 82% identity between sulfenylome persulfidome. With regard abscisic acid (ABA) signaling, widespread evidence shows an interconnection ABA plant response environmental stress. Proteomic analyses have revealed persulfidation several proteins involved network shown triggered ABA. In guard cells, complex interaction has also been described, specific components seems be mechanism.

Language: Английский

Citations

75
Persulfidation of ATG18a regulates autophagy under ER stress inArabidopsis DOI Open Access
Ángeles Aroca, Inmaculada Yruela, Cecilia Gotor

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(20)

Published: May 11, 2021

Significance Endoplasmic reticulum (ER) stress is a condition triggered by adverse environmental conditions, which in plants include extreme heat, pathogen infection, and drought. These stresses can have devastating effect on agricultural productivity, the appropriate responses of to are therefore critical. Autophagy macromolecular degradation pathway that activated response stress, including ER but mechanism it regulated still unclear. Here, we describe modification, persulfidation, key autophagy protein ATG18a affects its binding membranes controls activity. This tight regulation allows control tradeoff between growth tolerance.

Language: Английский

Citations

69
Hydrogen sulfide: an emerging component against abiotic stress in plants DOI
Ali Raza, Javaria Tabassum, Muhammad Salman Mubarik

et al.

Plant Biology, Journal Year: 2021, Volume and Issue: 24(4), P. 540 - 558

Published: Dec. 6, 2021

Abstract As a result of climate change, abiotic stresses are the most common cause crop losses worldwide. Abiotic significantly impair plants' physiological, biochemical, molecular and cellular mechanisms, limiting productivity under adverse conditions. However, plants can implement essential mechanisms against stressors to maintain their growth persistence such stressful environments. In nature, have developed several adaptations defence mitigate stress. Moreover, recent research has revealed that signalling molecules like hydrogen sulfide (H 2 S) play crucial role in mitigating effects environmental by implementing physiological biochemical mechanisms. Mainly, H S helps antioxidant systems, interacts with other nitric oxide (NO), reactive oxygen species (ROS), phytohormones, etc. These well‐known as key players moderate stresses. Currently, little progress been made understanding basis protective S; however, it is imperative understand using state‐of‐the‐art CRISPR‐Cas gene‐editing tool. Subsequently, genetic engineering could provide promising approach unravelling stress tolerance mediated exogenous/endogenous S. Here, we review advances beneficial roles conferring multiple plants. Further, also discuss interaction crosstalk between signal molecules; well highlighting some engineering‐based current future directions.

Language: Английский

Citations

63
Role of Exogenous and Endogenous Hydrogen Sulfide (H2S) on Functional Traits of Plants Under Heavy Metal Stresses: A Recent Perspective DOI Creative Commons
Muhammad Arif, Tahira Yasmeen, Zohaib Abbas

et al.

Frontiers in Plant Science, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 7, 2021

Improving growth and productivity of plants that are vulnerable to environmental stresses, such as heavy metals, is significant importance for meeting global food energy demands. Because metal toxicity not only causes impaired plant growth, it has also posed many concerns related human well-being, so mitigation pollution a necessary priority cleaner environment healthier world. Hydrogen sulfide (H2S), gaseous signaling molecule, involved in metal-related oxidative stress increased tolerance plants. It performs multifunctional roles regulation while reducing the adverse effects abiotic stress. Most effective function H2S eliminate by regulating several key physiobiochemical processes. Soil metals presents challenge due absence vegetation cover resulting depletion soil functions. However, use alleviators, H2S, along with suitable crop plants, considerable potential an management these contaminated soils. Overall, present review examines imperative role exogenous application different donors HMs toxicity, promoting stabilizing their processes, upregulating antioxidative metabolic activities. In addition, crosstalk regulators endogenous contribution phytotoxicity have been explored.

Language: Английский

Citations

59