Antibiotic Resistance: Challenges and Strategies in Combating Infections DOI Open Access

Jay Chavada,

Komal N Muneshwar,

Yash Ghulaxe

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 26, 2023

From a broader perspective, antibiotic or antimicrobial resistance is still evolving and spreading internationally. Infectious diseases have become more complex often impossible to cure, increasing morbidity mortality. Despite the failure of conventional, standard therapy, no new class antibiotics has been developed in last 20 years, which results various cutting-edge other tactics that can be used encounter these disease-causing microorganisms with resistance. In continued fight against bacterial infections, there an urgent requirement for antimicrobials. Antibiotic inevitable, pharmaceutical companies consistently show little interest funding novel research. Some methods are being as possible replacement conventional antibiotics. Combination target proteins enzymes cause resistance, systems delivery drug, physicochemical approaches, informal ways, such CRISPR-Cas system, some approaches. These approaches influence how multi-drug-resistant organisms handled human clinical settings.

Language: Английский

The role of nitric oxide and hydrogen sulfide in regulation of redox homeostasis at extreme temperatures in plants DOI Creative Commons
Yuriy E. Kolupaev, А. І. Yemets, Т. О. Yastreb

et al.

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 7, 2023

Nitric oxide and hydrogen sulfide, as important signaling molecules (gasotransmitters), are involved in many functions of plant organism, including adaptation to stress factors various natures. As redox-active molecules, NO H 2 S redox regulation functional activity proteins. They also maintaining cell homeostasis due their ability interact directly indirectly (functionally) with ROS, thiols, other molecules. The review considers the involvement nitric sulfide responses low high temperatures. Particular attention is paid role gasotransmitters interaction mediators (in particular, Ca 2+ ions ROS) formation adaptive extreme Pathways stress-induced enhancement synthesis plants considered. Mechanisms effect on some proteins system, well state antioxidant osmoprotective systems during temperatures, were analyzed. Possibilities practical use donors inductors discussed.

Language: Английский

Citations

34
Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease DOI Creative Commons
Swetha Pavani Rao, Prakashkumar Dobariya,

Harshini Bellamkonda

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 603 - 603

Published: March 1, 2023

3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well cytoplasm. 3-MST mediates reaction with dihydrolipoic acid and thioredoxin produce Hydrogen sulfide also produced through cystathionine beta-synthase gamma-lyase, along 3-MST, known alleviate a variety illnesses such cancer, heart disease, neurological conditions. The importance gamma-lyase biogenesis well-described, but documentation pathway limited. This account compiles current state knowledge about physiology pathology. Attempts at targeting for therapeutic benefit are discussed, highlighting potential target.

Language: Английский

Citations

27
Sulfide promotes tolerance to drought through protein persulfidation in Arabidopsis DOI Creative Commons
Ana Jurado-Flores, Ángeles Aroca, Luís C. Romero

et al.

Journal of Experimental Botany, Journal Year: 2023, Volume and Issue: 74(15), P. 4654 - 4669

Published: May 6, 2023

Abstract Hydrogen sulfide (H2S) is a signaling molecule that regulates essential plant processes. In this study, the role of H2S during drought was analysed, focusing on underlying mechanism. Pretreatments with before imposing plants substantially improved characteristic stressed phenotypes under and decreased levels typical biochemical stress markers such as anthocyanin, proline, hydrogen peroxide. also regulated drought-responsive genes amino acid metabolism, repressed drought-induced bulk autophagy protein ubiquitination, demonstrating protective effects pretreatment. Quantitative proteomic analysis identified 887 significantly different persulfidated proteins between control plants. Bioinformatic analyses more in revealed most enriched biological processes were cellular response to oxidative peroxide catabolism. Protein degradation, abiotic responses, phenylpropanoid pathway highlighted, suggesting importance persulfidation coping stress. Our findings emphasize promoter enhanced tolerance drought, enabling respond rapidly efficiently. Furthermore, main alleviating reactive oxygen species accumulation balancing redox homeostasis highlighted.

Language: Английский

Citations

26
Signaling Paradigms of H2S-Induced Vasodilation: A Comprehensive Review DOI Creative Commons
Constantin Munteanu, Cristina Raluca Gh. Popescu, Andreea-Iulia Vlădulescu-Trandafir

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1158 - 1158

Published: Sept. 25, 2024

Hydrogen sulfide (H

Language: Английский

Citations

10
Unraveling the potential of hydrogen sulfide as a signaling molecule for plant development and environmental stress responses: A state-of-the-art review DOI

Siloni Singh Bhadwal,

Shagun Verma,

Shahnawaz Hassan

et al.

Plant Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 212, P. 108730 - 108730

Published: May 15, 2024

Language: Английский

Citations

9
Nitric oxide and hydrogen sulfide modulate the NADPH-generating enzymatic system in higher plants DOI
Francisco J. Corpas, Salvador González‐Gordo, José M. Palma

et al.

Journal of Experimental Botany, Journal Year: 2020, Volume and Issue: 72(3), P. 830 - 847

Published: Sept. 16, 2020

Nitric oxide (NO) and hydrogen sulfide (H2S) are two key molecules in plant cells that participate, directly or indirectly, as regulators of protein functions through derived post-translational modifications, mainly tyrosine nitration, S-nitrosation, persulfidation. These modifications allow the participation both NO H2S signal a wide range cellular processes either physiological under stressful circumstances. NADPH participates redox status it is cofactor necessary for cell growth development. It involved significant biochemical routes such fatty acid, carotenoid proline biosynthesis, shikimate pathway, well detoxification including ascorbate-glutathione cycle, NADPH-dependent thioredoxin reductase (NTR), superoxide-generating oxidase. Plant have diverse mechanisms to generate by group NADP-dependent oxidoreductases ferredoxin-NADP (FNR), NADP-glyceraldehyde-3-phosphate dehydrogenase (NADP-GAPDH), malic enzyme (NADP-ME), isocitrate (NADP-ICDH), enzymes oxidative pentose phosphate designated glucose-6-phosphate (G6PDH) 6-phosphogluconate (6PGDH). consist different isozymes located subcellular compartments (chloroplasts, cytosol, mitochondria, peroxisomes) which contribute NAPDH pool. We provide comprehensive overview how promoted (tyrosine nitration S-nitrosation), (persulfidation), glutathione (glutathionylation), affect regulation dehydrogenases.

Language: Английский

Citations

60
The Versatile Roles of Sulfur-Containing Biomolecules in Plant Defense—A Road to Disease Resistance DOI Creative Commons
András Künstler,

Gábor Gullner,

Attila L. Ádám

et al.

Plants, Journal Year: 2020, Volume and Issue: 9(12), P. 1705 - 1705

Published: Dec. 3, 2020

Sulfur (S) is an essential plant macronutrient and the pivotal role of sulfur compounds in disease resistance has become obvious recent decades. This review attempts to recapitulate results on various functions sulfur-containing defense (SDCs) responses pathogens. These include containing amino acids such as cysteine methionine, tripeptide glutathione, thionins defensins, glucosinolates phytoalexins and, last but not least, reactive species hydrogen sulfide. SDCs play versatile roles both pathogen perception initiating signal transduction pathways that are interconnected with processes regulated by hormones (salicylic acid, jasmonic acid ethylene) oxygen (ROS). Importantly, ROS-mediated reversible oxidation residues proteins have profound effects protein like during infections. Indeed, multifaceted initiated should provide novel tools for breeding endow crops efficient invading

Language: Английский

Citations

57
Persulfidation-induced structural change in SnRK2.6 establishes intramolecular interaction between phosphorylation and persulfidation DOI Creative Commons
Sisi Chen, Xiaofeng Wang, Honglei Jia

et al.

Molecular Plant, Journal Year: 2021, Volume and Issue: 14(11), P. 1814 - 1830

Published: July 6, 2021

Language: Английский

Citations

56
Hydrogen sulfide (H2S) and potassium (K+) synergistically induce drought stress tolerance through regulation of H+-ATPase activity, sugar metabolism, and antioxidative defense in tomato seedlings DOI
Manzer H. Siddiqui, M. Nasir Khan, Soumya Mukherjee

et al.

Plant Cell Reports, Journal Year: 2021, Volume and Issue: 40(8), P. 1543 - 1564

Published: June 17, 2021

Language: Английский

Citations

55
Hydrogen sulfide: An emerging signaling molecule regulating drought stress response in plants DOI
Meenakshi Thakur,

Anjali Anand

Physiologia Plantarum, Journal Year: 2021, Volume and Issue: 172(2), P. 1227 - 1243

Published: April 16, 2021

Hydrogen sulfide (H2 S) is a small, reactive signaling molecule that produced within chloroplasts of plant cells as an intermediate in the assimilatory sulfate reduction pathway by enzyme sulfite reductase. In addition, H2 S also cytosol and mitochondria desulfhydration l-cysteine catalyzed desulfhydrase (DES1) from β-cyanoalanine mitochondria, reaction β-cyano-Ala synthase C1 (CAS-C1). exerts its numerous biological functions post-translational modification involving oxidation cysteine residues (RSH) to persulfides (RSSH). At lower concentrations (10-1000 μmol L-1 ), shows huge agricultural potential it increases germination rate, size, fresh weight, ultimately crop yield. It involved abiotic stress response against drought, salinity, high temperature, heavy metals. donor, for example, sodium hydrosulfide (NaHS), has been exogenously applied on plants various researchers provide drought tolerance. Exogenous application results accumulation polyamines, sugars, glycine betaine, enhancement antioxidant activities drought-induced osmotic oxidative stress, thus, providing adaptation plants. biochemical level, administration donors reduces malondialdehyde content lipoxygenase activity maintain cell integrity, causes abscisic acid-mediated stomatal closure prevent water loss through transpiration, accelerates photosystem II repair cycle. Here, we review crosstalk with secondary messengers phytohormones towards regulation emphasize approaches can be addressed strengthen research this area.

Language: Английский

Citations

47