Nephrology Dialysis Transplantation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
In
chronic
kidney
disease
(CKD)
the
nitric
oxide
(NO)-soluble
guanylate
cyclase
(sGC)-cyclic
guanosine
monophosphate
(cGMP)
pathway
is
impaired.
Runcaciguat,
an
sGC
activator,
activates
heme-free
sGC,
restoring
cGMP
production.
This
phase
2a
trial
studied
efficacy,
safety,
and
tolerability
of
runcaciguat
in
CKD
patients
with
or
without
sodium-glucose
co-transporter-2
inhibitor
(SGLT2i).
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6579 - 6579
Published: March 31, 2023
Acrolein,
a
highly
reactive
α,β-unsaturated
aldehyde,
is
compound
involved
in
the
pathogenesis
of
many
diseases,
including
neurodegenerative
cardiovascular
and
respiratory
diabetes
mellitus,
development
cancers
various
origins.
In
addition
to
environmental
pollution
(e.g.,
from
car
exhaust
fumes)
tobacco
smoke,
serious
source
acrolein
our
daily
diet
improper
thermal
processing
animal
vegetable
fats,
carbohydrates,
amino
acids.
Dietary
intake
one
main
routes
human
exposure
acrolein,
which
major
public
health
concern.
This
review
focuses
on
molecular
mechanisms
activity
context
its
involvement
diseases
related
digestive
system,
diabetes,
alcoholic
liver
disease,
intestinal
cancer.
Food Chemistry Advances,
Journal Year:
2024,
Volume and Issue:
4, P. 100666 - 100666
Published: March 12, 2024
Diabetes
mellitus
(DM)
is
a
devastating
medical
condition
which
has
become
one
of
the
top
ten
causes
most
deaths,
with
70
%
increase
since
2000.
DM
characterised
by
elevated
plasma
glucose
levels.
The
excess
levels
have
been
found
to
causal
link
development
reactive
oxygen
species
leading
oxidative
stress.
Failure
body's
intracellular
antioxidant
system
compensate
for
increased
stress
results
in
activation
stress-sensitive
signalling
pathways
and
ultimately
cellular
damage,
leads
pathogenesis
DM.
It
evident
that
naturally
occurring
dietary
antioxidants
such
as
vitamins
E,
A,
C,
plant
polyphenols,
carotenoids,
flavonoids,
glutathione,
alpha-lipoic
acid,
polyamines
all
provide
significant
protection
against
diabetes.
According
research,
therapy
protects
beta-cell
stress-induced
apoptosis,
preserves
function,
reduces
diabetic-related
complications.
As
result,
use
dramatically,
not
only
because
their
natural
therapeutic
effects,
but
also
safety
concerns
associated
synthetic
antioxidants,
well
affordability
availability.
This
paper
compiled
current
research
on
role
diabetes
significance
mitigating
effect.
Nephrology Dialysis Transplantation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
In
chronic
kidney
disease
(CKD)
the
nitric
oxide
(NO)-soluble
guanylate
cyclase
(sGC)-cyclic
guanosine
monophosphate
(cGMP)
pathway
is
impaired.
Runcaciguat,
an
sGC
activator,
activates
heme-free
sGC,
restoring
cGMP
production.
This
phase
2a
trial
studied
efficacy,
safety,
and
tolerability
of
runcaciguat
in
CKD
patients
with
or
without
sodium-glucose
co-transporter-2
inhibitor
(SGLT2i).
