Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3454 - 3454

Published: Aug. 4, 2023

It is well known that neurodegenerative diseases’ development and progression are accelerated due to oxidative stress inflammation, which result in impairment of mitochondrial function, cellular damage, dysfunction DNA repair systems. The increased consumption antioxidants can postpone the these disorders improve quality patients’ lives who have already been diagnosed with diseases. Prolonging life span developed countries contributes an increase incidence ratio chronic age-related disorders, such as PD (Parkinson’s disease), AD (Alzheimer’s or numerous forms dementias. Dietary supplementation neuroprotective plant-derived polyphenols might be considered important element healthy aging. Some cognition, mood, visual functions, language, verbal memory functions. Polyphenols bioavailability differs greatly from one compound another determined by solubility, degree polymerization, conjugation, glycosylation resulting chemical structure. still unclear beneficial because their potential depends on efficient transport across BBB (blood-brain barrier), bioavailability, stability CNS (central nervous system). brain functions having a direct impact cells processes CNS. For effect, polyphenolic compounds must able overcome accumulate tissue. In this review, latest achievements studies (animal models clinical trials) effect activity function described. plant may summarized role increasing plasticity related cognition improvement. As reversible MAO (monoamine oxidase) inhibitors, mood modulators neuronal self-being through dopamine, serotonin, noradrenaline amounts After analyzing prohealth effects various eating patterns, it was postulated synergistic interactions between individual dietary components. act endothelial BBB’s integrity reduce thus protecting additional injury during stroke autoimmune Polyphenolic capable lowering blood pressure improving cerebral flow. Many revealed nutritional model based has ameliorate cognitive associated disorders. Randomized trials also shown improvement foods rich flavonoids independent age health conditions. therapeutic use, sufficient quantities cross reach tissue active form. An issue action not only penetration BBB, but metabolism localization. low. most usual oral administration conflicts bioavailability. main factors limit process efficacy are: selective permeability gastrointestinal transformations, poor absorption, rapid hepatic colonic metabolism, systemic elimination. Thus, phenolic inadequate for human applications any effects. recent years, new strategies attempted order exert benefits Converting into nanostructures theories proposed enhance following nanoscale delivery systems used encapsulate polyphenols: nanocapsules, nanospheres, micelles, cyclodextrins, solid lipid nanoparticles, liposomes. results great expectations wide-scale effective use prevention Thus far, natural studied neuroprotectors. Perhaps some modification structure given polyphenol its transportation BBB. However, questions should answered before developing medications polyphenols.

Language: Английский

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Gold Nanoparticles in Neurological Diseases: A Review of Neuroprotection

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2360 - 2360

Published: Feb. 17, 2024

This review explores the diverse applications of gold nanoparticles (AuNPs) in neurological diseases, with a specific focus on Alzheimer's disease (AD), Parkinson's (PD), and stroke. The introduction highlights pivotal role neuroinflammation these disorders introduces unique properties AuNPs. review's core examines mechanisms by which AuNPs exert neuroprotection anti-neuro-inflammatory effects, elucidating various pathways through they manifest properties. potential therapeutic AD are discussed, shedding light promising avenues for therapy. also prospects utilizing PD interventions, presenting hopeful outlook future treatments. Additionally, delves into providing after strokes, emphasizing their significance mitigating cerebrovascular accidents' aftermath. Experimental findings from cellular animal models consolidated to provide comprehensive overview AuNPs' effectiveness, offering insights impact at both vivo levels. enhances our understanding diseases lays groundwork innovative strategies neurology.

Language: Английский

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Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer’s disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology, and amyloidogenesis

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124218 - 124218

Published: May 9, 2024

Language: Английский

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Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 79, P. 101658 - 101658

Published: June 2, 2022

Language: Английский

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Role of pro-inflammatory cytokines in Alzheimer's disease and neuroprotective effects of pegylated self-assembled nanoscaffolds

Current Research in Pharmacology and Drug Discovery, Journal Year: 2022, Volume and Issue: 4, P. 100149 - 100149

Published: Dec. 20, 2022

Neurodegeneration and synaptic loss in Alzheimer's disease (AD) lead to impairment memory functions. Neuroinflammation causes activation of microglia astrocytes cells that locally systemically produces inflammatory cytokines which can serve as early diagnostic markers or therapeutic targets AD. Pro-inflammatory (Interleukins (IL-1β, IL-6 IL-10) tumor necrosis factor (TNF α)) levels were estimated serum, cerebral tissue, hepatic renal tissue treatment groups scopolamine-induced amnesia mice model using ELISA protocol. The results showed AD exhibited elevated IL1β, IL6, IL10 TNFα indicate contribution pro-inflammatory the progression A significant reduction concentration IL-10 TNF-α noticed animal group treated with marketed memantine tablet (Admenta), pure drug (MEMp), memantine-poly (lactic-co-glycolic acid) self-assembled nanoscaffolds (MEM-PLGA) SANs, Polyethylene Glycol coated [(PEG-MEM-PLGA) SANs] [(lactic-co-glycolic acid)] grafted Bone Marrow Derived Stem Cell ((PEG-MEM-PLGA) SANs-BMSc), whereas a high level was observed tissues normal induced emerging potential trigger either neurons survival after injury causing neurodegeneration cell apoptosis. Neuroregenerative stem helps proliferation neuronal thus improves cognition model.

Language: Английский

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Nanoparticles with dense poly(ethylene glycol) coatings with near neutral charge are maximally transported across lymphatics and to the lymph nodes

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 145, P. 146 - 158

Published: April 2, 2022

Language: Английский

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Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors

Archiv der Pharmazie, Journal Year: 2022, Volume and Issue: 355(4)

Published: Jan. 7, 2022

In this study, a series of novel Schiff base derivatives containing pyrazolone ring (2a-e) were designed, successfully synthesized for the first time, and characterized by elemental analysis some spectroscopic methods. These compounds tested their inhibitory activities on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase isoenzymes I II (hCA II). All molecules indicated significant inhibition effects with IC50 values ranging from 14.15 to 107.62 nM against these enzymes. Compound 2d showed most potent activity among toward AChE BChE (IC50 = 15.07 nM) compared standard drug neostigmine. We determined that ranged between 16.86 57.96 hCA 15.24-46.21 II. As consequence, we may say be used as potential candidates in later studies.

Language: Английский

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PLGA/PEG Nanoparticles Loaded with Cyclodextrin-Peganum harmala Alkaloid Complex and Ascorbic Acid with Promising Antimicrobial Activities

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(1), P. 142 - 142

Published: Jan. 7, 2022

Antimicrobial drugs face numerous challenges, including drug resistance, systemic toxic effects, and poor bioavailability. To date, treatment choices are limited, which warrants the search for novel potent antivirals, those extracted from natural products. The seeds of

Language: Английский

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The Hitchhiker’s Guide to Human Therapeutic Nanoparticle Development

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 247 - 247

Published: Jan. 21, 2022

Nanomedicine plays an essential role in developing new therapies through novel drug delivery systems, diagnostic and imaging vaccine development, antibacterial tools, high-throughput screening. One of the most promising systems are nanoparticles, which can be designed with various compositions, sizes, shapes, surface modifications. These nanosystems have improved therapeutic profiles, increased bioavailability, reduced toxicity product they carry. However, clinical translation nanomedicines requires a thorough understanding their properties to avoid problems questioned aspect nanosystems: safety. The particular physicochemical nano-drugs lead need for additional safety, quality, efficacy testing. Consequently, challenges arise during characterization, production process, vitro vivo stages development these biopharmaceuticals. lack specific regulatory framework nanoformulations has caused significant gaps requirements needed successful approval, especially tests that demonstrate safety efficacy. Researchers face many difficulties establishing evidence extrapolate results from one level another, example, demonstration phase phase. Additional guidance is required cover particularities this type product, as some do not allow accurate assessment NPs sufficient success. This work aims identify current issues implementation nanoparticle assays describe major researchers faced when exposing formulation. We further reflect on standards approval biopharmaceuticals demanded by agencies. Our will provide helpful information improve success compiling described literature support encapsulation system. propose step-by-step approach different nanoformulations, design stage, exemplifying measures taken agencies respond challenges.

Language: Английский

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Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(16), P. 5390 - 5409

Published: Jan. 1, 2023

Microneedles (MNs) have recently been found to applications in drug, vitamin, protein and vaccine delivery. Polymeric MN arrays continue attract increasing attention due their capability bypass the skin's stratum corneum (SC) barrier with minimal invasiveness. These carriers can achieve targeted intradermal delivery of drugs vaccines improve transdermal level. As a nontoxic FDA-approved copolymer, polylactic glycolic acid (PLGA) has good biocompatibility biodegradability. Currently, PLGA-based MNs noticeable tendency be utilized as system. This study focuses on most recent advances MNs. Both PLGA nanoparticle-based matrix-based MNs, created for vaccines, drugs, proteins other therapeutic agents, are discussed. The paper also discusses various types potential applications. Finally, prospects challenges reviewed.

Language: Английский

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