Effect of Nanohydroxyapatite on Silk Fibroin-Chitosan Interactions. Molecular Dynamics Study DOI Open Access
Maciej Przybyłek, Anna Tuwalska, Damian Ledziński

et al.

Published: April 3, 2024

Fibroin-chitosan composites, especially those containing nanohydroxyapatite, show potential for bone tissue regeneration. The physicochemical properties of these biocomposites depend on the compatibility between their components. In this study, intermolecular interactions fibroin and chitosan were analyzed using a molecular dynamics approach. Two types systems investigated: one acetic acid other calcium (Ca²⁺) hydrogen phosphate (HPO₄²⁻) ions mimicking hydroxyapatite conditions. After obtaining optimal equilibrium structures, distributions several including bonds, ionic contacts, hydrophobic contacts along with structural energetical features examined. calculated binding energy values fibroin-chitosan complexes confirm remarkable stability. high affinity can be explained by formation dense network considered biopolymers. These found to primarily bonds involving ALA, ARG, ASN, ASP, GLN, GLU, GLY, LEU, PRO, SER, THR, TYR, VAL residues. As it was established, complexation maintains β-sheet conformation peptide. β-Sheet fragments in are involved significant amount chitosan.

Language: Английский

Developmental Formulation Principles of Food Preservatives by Nanoencapsulation—Fundamentals, Application, and Challenges DOI

M. Lavanya,

S. Karthick Raja Namasivayam,

Arun John

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2024, Volume and Issue: 196(10), P. 7503 - 7533

Published: May 7, 2024

Language: Английский

Citations

19
A review of chitosan-based multifunctional nanocomposites for drug/gene/protein delivery and gene therapy in cancer treatments: Promises, challenges and outlooks DOI
Ali Khorasani, Seyed Morteza Naghib

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141394 - 141394

Published: Feb. 1, 2025

Language: Английский

Citations

2
A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years DOI Creative Commons
Magdalena Stevanović, Nenad Filipović

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 670 - 670

Published: May 16, 2024

In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These offer promising strategies for targeted and controlled drug while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, healthcare landscape is constantly evolving, necessitating continual development innovative therapeutic approaches (DDSs). DDSs play a pivotal role enhancing treatment efficacy, minimizing adverse effects, optimizing patient compliance. Among these, nanotechnology-driven garnered due to their unique properties, such as improved solubility, release, delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., versatile platforms tissue engineering applications. Additionally, hold immense promise, leveraging natural or synthetic biopolymers encapsulate drugs enable release. numerous advantages, biocompatibility, biodegradability, low immunogenicity. The utilization polysaccharides, polynucleotides, proteins, polyesters biopolymer matrices further enhances versatility applicability DDSs. Moreover, substances emerged key players combating diseases, offering protection against cellular damage chronic illnesses. nanoformulations represents burgeoning research area, substantial increase publications years. This review provides comprehensive overview developments within this area over past five It discusses various materials, fabrication techniques, stabilizers, factors influencing degradation, it highlights emerging trends, challenges, prospects rapidly evolving field.

Language: Английский

Citations

11
Recycling Technologies for Biopolymers: Current Challenges and Future Directions DOI Open Access
Adenike A. Akinsemolu,

Adetola M. Idowu,

Helen Onyeaka

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2770 - 2770

Published: Sept. 30, 2024

Plastic pollution is a major driver of climate change that associated with biodiversity loss, greenhouse gas emissions, and negative soil, plant, animal, human health. One the solutions has been proposed currently reducing adverse effects plastic on planet replacement synthetic plastics biopolymers. The biodegradable polymers have adapted for most applications plastic. However, their use disposal present some sustainability challenges. Recycling emerges as an effective way promoting biopolymer use. In this article, we review recycling viable solution to improve biopolymers, emphasizing current types technologies employed in challenges faced adoption. Our exploration future directions conversion biopolymers into new reuse establishes connection between established continuous technological innovation, integration circular economy models, establishment strengthening collaborations among key stakeholders relevant industries necessary steps adoption, full utilization, improvement By connecting these factors, study lays foundation roadmap improved processes promote alternatives.

Language: Английский

Citations

10
Biopolymers: An inclusive review DOI Creative Commons
Great Iruoghene Edo, Winifred Ndudi,

Ali B. M. Ali

et al.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100418 - 100418

Published: Feb. 1, 2025

Language: Английский

Citations

1
The Utilization of Biopolymer Hydrogels to Encapsulate and Protect Probiotics in Foods DOI
Great Iruoghene Edo, Alice Njolke Mafe, Patrick Othuke Akpoghelie

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Functionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies DOI Creative Commons

Shaymaa A. Abdulmalek,

Abdulrahman M. Saleh,

Yasmin R. Shahin

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(9), P. 6941 - 6962

Published: April 9, 2024

Abstract Oncogenic microRNA (miRNA), especially miRNA-21 upregulation in triple-negative breast cancer (TNBC), suggests a new class of therapeutic targets. In this study, we aimed to create GE11 peptide-conjugated small interfering RNA-loaded chitosan nanoparticles (GE11-siRNA-CSNPs) for the targeting EGFR overexpressed TNBC and selectively inhibit expression. A variety in-silico vitro cellular molecular studies were conducted investigate binding affinities specific targets used as well anticancer efficacies mechanisms GE11-siRNA-CSNPs cells. An assessment reveals distinct affinity with siRNA between extracellular domain synthesized peptides. Notably, results showed that revealed have better cytotoxicity against It significantly inhibits expression, cell migration, colony formation. The also indicated impeded cycle progression. induces death by reducing expression antiapoptotic gene Bcl-2 increasing proapoptotic genes Bax, Caspase 3, 9. Additionally, docking analysis immunoblot investigations verified GE1-siRNA-CSNPs, which specifically target cells suppress miRNA-21, can prevent effects on proliferation via controlling subsequently inhibiting PI3K/AKT ERK1/2 signaling axis. design, cells, offers novel approach treatment improved effectiveness. This study could be promising candidate further an additional strategy TNBC. Graphical

Language: Английский

Citations

8
Pharmaceutical Applications of Biomass Polymers: Review of Current Research and Perspectives DOI Open Access

Cornelia Bejenaru,

Antonia Radu, Adina‐Elena Segneanu

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(9), P. 1182 - 1182

Published: April 23, 2024

Polymers derived from natural biomass have emerged as a valuable resource in the field of biomedicine due to their versatility. Polysaccharides, peptides, proteins, and lignin demonstrated promising results various applications, including drug delivery design. However, several challenges need be addressed realize full potential these polymers. The current paper provides comprehensive overview latest research perspectives this area, with particular focus on developing effective methods efficient systems. This review aims offer insights into opportunities associated use polymers provide roadmap for future field.

Language: Английский

Citations

6
Machine Learning-Based Process Optimization in Biopolymer Manufacturing: A Review DOI Open Access
Ivan Malashin,

D. A. Martysyuk,

В С Тынченко

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(23), P. 3368 - 3368

Published: Nov. 29, 2024

The integration of machine learning (ML) into material manufacturing has driven advancements in optimizing biopolymer production processes. ML techniques, applied across various stages production, enable the analysis complex data generated throughout identifying patterns and insights not easily observed through traditional methods. As sustainable alternatives to petrochemical-based plastics, biopolymers present unique challenges due their reliance on variable bio-based feedstocks processing conditions. This review systematically summarizes current applications techniques aiming provide a comprehensive reference for future research while highlighting potential enhance efficiency, reduce costs, improve product quality. also shows role algorithms, including supervised, unsupervised, deep

Language: Английский

Citations

5
Biocomposites and Poly(lactic acid) in Active Packaging: A Review of Current Research and Future Directions DOI Open Access

Sofiane Akhrib,

Souad Djellali, N. Haddaoui

et al.

Polymers, Journal Year: 2024, Volume and Issue: 17(1), P. 3 - 3

Published: Dec. 24, 2024

The alarming rise in environmental pollution, depletion of global resources, and increasing health consciousness have placed significant pressure on the development eco-friendly, sustainable materials. Consequently, green, environmentally friendly materials made from biobased and/or biodegradable sources are gaining recognition political support as alternatives to petroleum-based, non-biodegradable Bio-based packaging materials, particular, widely used across all industrial sectors, with a growing demand for solutions that preserve food quality extend shelf life. Within this context, concept “active packaging” (AP) is attracting considerable interest. While traditional view they should be basically inert, active involves intentional interactions packaged product or surrounding atmosphere, providing enhanced protection against degradation caused by human actions factors. This work aims highlight impact biocomposites sector, driven synergistic integration nanofillers agents, while an in-depth analysis key mechanisms strategies underlying their functionality. Particular emphasis poly(lactic acid)(PLA), presenting comprehensive review innovative approaches enhance performance PLA-based packaging, focus improving antioxidant antimicrobial properties meet demands efficient solutions.

Language: Английский

Citations

4