Antifungal susceptibility profile of Candida species and uncommon yeasts from drug abusers with oral candidiasis DOI Creative Commons
Aynaz Ghojoghi, Sadegh Khodavaisy,

Ali Zarei Mahmoudabadi

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 26, 2024

In Iran, there is limited information regarding the species distribution and antifungal susceptibility profiles of yeast isolates from drug addicts suffering oral candidiasis (OC). this study, 104 isolates, including 98 Candida 6 uncommon yeasts, were collected 71 abusers with OC. The spp. yeasts to amphotericin B (AMB), itraconazole (ITC), nystatin (NYC), fluconazole (FLC), caspofungin (CAS) evaluated using CLSI broth microdilution method. prevalence OC in sampled population was found be 29%. profile revealed remarkable sensitivity, 100% 99% susceptible NYC AMB, respectively. However, concerning levels resistance or non-wild-type minimum inhibitory concentrations (MICs) observed, 13.2% showing FLC, ITC, 16.3% CAS. Notably, 35.2% patients showed mixed species, while 5.1% exhibited multidrug resistance. analysis that overall frequencies highest MICs observed for Furthermore, within six non-Candida identified, Hanseniaspora opuntiae one isolate Pichia kluyveri FLC respectively, all AMB NYC. Additionally, simultaneously high two drugs ITC CAS FLC. findings present study suggest can suitable choices empiric treatment both common infections substance abuse patients.

Language: Английский

Archaeological dental calculus: A rich bioarchive for exploring Classical Antiquity through ancient DNA methods DOI
Sterling Wright

Journal of Archaeological Science Reports, Journal Year: 2025, Volume and Issue: 62, P. 105038 - 105038

Published: Feb. 19, 2025

Language: Английский

Citations

0
The Oral–Gut Microbiome–Brain Axis in Cognition DOI Creative Commons

Noorul Ain Adil,

Christabel Omo-Erigbe,

Hariom Yadav

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 814 - 814

Published: April 3, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.

Language: Английский

Citations

0
Antifungal susceptibility profile of Candida species and uncommon yeasts from drug abusers with oral candidiasis DOI Creative Commons
Aynaz Ghojoghi, Sadegh Khodavaisy,

Ali Zarei Mahmoudabadi

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 26, 2024

In Iran, there is limited information regarding the species distribution and antifungal susceptibility profiles of yeast isolates from drug addicts suffering oral candidiasis (OC). this study, 104 isolates, including 98 Candida 6 uncommon yeasts, were collected 71 abusers with OC. The spp. yeasts to amphotericin B (AMB), itraconazole (ITC), nystatin (NYC), fluconazole (FLC), caspofungin (CAS) evaluated using CLSI broth microdilution method. prevalence OC in sampled population was found be 29%. profile revealed remarkable sensitivity, 100% 99% susceptible NYC AMB, respectively. However, concerning levels resistance or non-wild-type minimum inhibitory concentrations (MICs) observed, 13.2% showing FLC, ITC, 16.3% CAS. Notably, 35.2% patients showed mixed species, while 5.1% exhibited multidrug resistance. analysis that overall frequencies highest MICs observed for Furthermore, within six non-Candida identified, Hanseniaspora opuntiae one isolate Pichia kluyveri FLC respectively, all AMB NYC. Additionally, simultaneously high two drugs ITC CAS FLC. findings present study suggest can suitable choices empiric treatment both common infections substance abuse patients.

Language: Английский

Citations

0