Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102665 - 102665

Published: Jan. 1, 2025

Language: Английский

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Targeting c-MYC G-Quadruplexes for Cancer Treatment with Small Molecules

Scientia Pharmaceutica, Journal Year: 2025, Volume and Issue: 93(1), P. 6 - 6

Published: Jan. 22, 2025

Novel therapies are required due to the rising cancer burden. Conventional chemotherapeutics tend be particularly toxic, but there is a promising alternative for oncogenes, such as c-MYC. Often overexpressed in many types, potential c-MYC oncogene seems essential development of cancer. Targeting protein directly was limited, these DNA structures composed guanine-rich sequences suppress transcription. This review discusses recent advances developing small compounds that selectively bind and stabilize G-quadruplexes (G4). These molecules have also shown promise inhibition signaling tumor growth, suggesting G-quadruplex targeting could therapeutic

Language: Английский

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Anti-Aging Effects of Flavonoids from Plant Extracts

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2441 - 2441

Published: Aug. 2, 2024

Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues' cells' morphology functionality consequently being responsible for aging-related diseases. Taking into account actual preoccupations of both consumers researchers, healthy anti-aging alternatives are intensively studied in order to address such concerns. Due their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights possibilities use extracted from various plants potential on skin, brain, heart. Moreover, anticarcinogenic, anti-inflammatory, anti-diabetic properties summarized, along with senescence-associated mechanisms. Both nutraceutical cosmeceutical fields continuously developing originating promising candidates obtain products. Thus, bioactive compounds' extraction subsequent involvement innovative product manufacturing must carefully performed while aware intrinsic extrinsic factors that may affect phytochemicals' structures, bioavailability, health effects.

Language: Английский

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Flavonoids and Flavonoid-Based Nanopharmaceuticals as Promising Therapeutic Strategies for Colorectal Cancer—An Updated Literature Review

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 231 - 231

Published: Feb. 8, 2025

Colorectal cancer (CRC) represents one of the most serious health issues and third commonly diagnosed worldwide. However, treatment options for CRC are associated with adverse reactions, in some cases, resistance can develop. Flavonoids have emerged as promising alternatives prevention therapy due to their multitude biological properties ability target distinct processes involved pathogenesis. Their innate disadvantageous (e.g., low solubility stability, reduced bioavailability, lack tumor specificity) delayed potential inclusion flavonoids regimens but hastened design nanopharmaceuticals comprising a flavonoid agent entrapped nanosized delivery platform that not only counteract these inconveniences also provide an augmented therapeutic effect elevated safety profile by conferring targeted action. Starting brief presentation pathological features overview classes, present study comprehensively reviews anti-CRC activity different from mechanistic perspective while portraying latest discoveries made area flavonoid-containing nanocarriers proved efficient management. This review concludes showcasing future perspectives advancement flavonoid-based research.

Language: Английский

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Orbea variegata (L.) Haw in skin carcinogenesis: insights from an in vivo male Swiss mouse model study

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 87(15), P. 630 - 645

Published: May 13, 2024

Skin cancer is the most widespread type of malignant tumor representing a major public health concern. Considering numerous side effects associated with conventional treatments, phytotherapy may be regarded as viable medicinal alternative. This study aimed to investigate therapeutic potential Orbea variegata (L.) Haw, an ornamental plant, in treating skin using animal model induced by combination ultraviolet (UV) irradiation and sulfuric acid treatment. The hydroethanolic extract underwent phytochemical characterization, identifying presence reducing sugars, coumarins, alkaloids, flavonoids, tannins, saponins through qualitative screening. Quantitative analysis demonstrated significant amounts phenolic compounds (29.435 ± 0.571 mg GAE/g dry extract), flavonoids (6.711 0.272 QE/g tannins (274.037 11.3 CE/g extract). administration two concentrations (1 or 2 g/kg) male Swiss mice exhibited no marked adverse effects, evidenced serum aspartate aminotransferase (AST) alanine (ALT) enzyme activity levels. In addition, significantly reduced hyperplasia inflammation UV/sulfuric treatment noted tissue analyses decreased protein expression nuclear proliferation marker (Ki-67). improvement was decrease oxidative stress, indicated diminished lipid peroxidation levels, restoration endogenous antioxidant catalase (CAT) control Our findings considered for cancer, exhibiting its apparent safety efficacy carcinogenesis acid-induced mouse model, attributed content activities.

Language: Английский

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Integrating ADMET, enrichment analysis, and molecular docking approach to elucidate the mechanism of Artemisia herba alba for the treatment of inflammatory bowel disease-associated arthritis

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 87(20), P. 836 - 854

Published: July 19, 2024

Inflammatory Bowel Disease-Associated Arthritis (IBD-associated arthritis) poses a significant challenge, intertwining the complexities of both inflammatory bowel disease (IBD) and arthritis, significantly compromising patient quality life. While existing medications offer relief, these drugs often initiate adverse effects, necessitating requirement for safer therapeutic alternatives.

Language: Английский

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Flavonoids as key players in cold tolerance: molecular insights and applications in horticultural crops

Horticulture Research, Journal Year: 2025, Volume and Issue: 12(4)

Published: Jan. 2, 2025

Abstract Cold stress profoundly affects the growth, development, and productivity of horticultural crops. Among diverse strategies plants employ to mitigate adverse effects cold stress, flavonoids have emerged as pivotal components in enhancing plant resilience. This review was written systematically highlight critical role tolerance, aiming address increasing need for sustainable practices under climate stress. We provide a comprehensive overview tolerance crops, emphasizing their biosynthesis pathways, molecular mechanisms, regulatory aspects conditions. discuss how act antioxidants, scavenging reactive oxygen species (ROS) generated during they regulate gene expression by modulating stress-responsive genes pathways. Additionally, we explore application through genetic engineering breeding strategies, offering insights into practical interventions improving crop Despite significant advances, research gap remains understanding precise mechanisms which specific confer resistance, especially across different species. By addressing current knowledge gaps, proposing future directions highlighting implications horticulture, aim advance enhance

Language: Английский

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Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 65 - 65

Published: Jan. 10, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation, joint pain, and progressive cartilage bone erosion. Despite advancements in RA management with disease-modifying antirheumatic drugs (DMARDs) biologics, some patients remain refractory to conventional treatments. Tetracyclines, such as minocycline doxycycline, exhibit anti-inflammatory immunomodulatory properties, making them potential supplementary This narrative review explores their effectiveness, mechanisms of action, safety profiles, current challenges care. Tetracyclines have demonstrated significant effects, including the inhibition pro-inflammatory cytokines matrix metalloproteinases (MMPs), which are critical pathology. Clinical trials, double-blind, placebo-controlled studies, shown efficacy reducing symptoms, particularly early cases. However, use remains limited inconsistent evidence, small sample sizes, concerns about antimicrobial resistance. Current guidelines for do not explicitly recommend tetracyclines due these limitations, although off-label may be considered specific The tetracycline restricted drug interactions causing bacterial resistance alongside unpredictable patient responses, hence necessity prudence its prescription within clinical setting. To overcome development safer compounds, in-depth silico analyses, integration personalized medicine approaches needed. Overall, show promise adjunct therapies dual actions. highlights need further research address gaps modified reduced effects improved well optimize outcomes.

Language: Английский

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Pharmaceutical technological trends containing flavonoids: a patent review

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 17(3), P. 363 - 379

Published: Jan. 21, 2025

Flavonoids such as silibinin, hesperetin, and phloretin exhibit well-documented biological activities, including anti-inflammatory, cytoprotective, anticarcinogenic, antioxidant effects. However, their clinical application remains limited due to challenges poor aqueous solubility, low bioavailability, restricted intestinal absorption, which can significantly reduce pharmacological efficacy. This review analyzed patents related innovative pharmaceutical technologies for flavonoids. The analysis used databases from the World Intellectual Property Organization European Patent Office. Following a comprehensive screening process, 38 were selected detailed examination. These highlighted numerous studies on novel formulations, characterizations, proprietary conditions. highlights technologies, nanocapsules, nanoemulsions, solid dispersions, phospholipid carriers, inclusion complexes, microemulsions, other advanced systems, enhance bioactive molecules' water solubility stability. Consequently, these improve permeability absorption through intended administration route, demonstrating potential of flavonoids promising candidates various treatments, particularly when integrated into technologies.

Language: Английский

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Phytochemical Profile, Antioxidant and Antimicrobial Activity of Two Species of Oak: Quercus sartorii and Quercus rysophylla

Applied Biosciences, Journal Year: 2025, Volume and Issue: 4(1), P. 13 - 13

Published: March 4, 2025

The genus Quercus (Fagaceae) is one of the most widely distributed and species-diverse trees in Northern Hemisphere. present study addresses investigation phyto-chemical profile by ten assays, antioxidant activity scavenging DPPH radicals, total phenolic content, flavonoids, antimicrobial against three pathogenic bacteria with foliage two species red oak (Quercus sartorii rysophylla). Both showed a high content aqueous extract (22,342.10 ± 3076.5 mg GAE/kg plant 17,747.14 1139.9 plant, respectively). In flavonoid Q. higher amount ethanolic (24,587.42 996.3 QE/kg plant), while for rysophylla, it was methanolic (19,875.66 2754.01 plant). radical activity, highest percentage inhibition (81.14 1.7%), (82.60 2.7%). tests, halos were obtained strains Acinetobacter baumannii Staphylococcus aureus both species. All this gives guideline to comprehensively elucidate metabolites these further application dispute or diseases related imbalance reactive oxygen (ROS).

Language: Английский

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