Translational Neurodegeneration,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Dec. 3, 2024
Abstract
Promising
therapeutic
strategies
are
being
explored
to
replace
or
regenerate
the
neuronal
populations
that
lost
in
patients
with
neurodegenerative
disorders.
Several
research
groups
have
attempted
direct
reprogramming
of
astrocytes
into
neurons
by
manipulating
expression
polypyrimidine
tract-binding
protein
1
(PTBP1)
and
claimed
putative
converted
be
functional,
which
led
improved
disease
outcomes
animal
models
several
However,
a
few
other
studies
reported
data
contradict
these
claims,
raising
doubt
about
whether
PTBP1
suppression
truly
reprograms
potential
this
approach.
This
review
discusses
recent
advances
regenerative
therapeutics
including
stem
cell
transplantations
for
central
nervous
system
disorders,
particular
focus
on
Parkinson’s
Alzheimer’s
diseases.
We
also
provide
perspective
controversy
considering
astrocyte
heterogeneity
may
key
understanding
discrepancy
published
studies,
certain
subpopulations
glial
cells
more
readily
neurons.
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 26, 2024
Abstract
Cartilage,
an
important
connective
tissue,
provides
structural
support
to
other
body
tissues,
and
serves
as
a
cushion
against
impacts
throughout
the
body.
Found
at
end
of
bones,
cartilage
decreases
friction
averts
bone-on-bone
contact
during
joint
movement.
Therefore,
defects
can
result
from
natural
wear
tear,
or
traumatic
events,
such
injuries
sudden
changes
in
direction
sports
activities.
Overtime,
these
which
do
not
always
produce
immediate
symptoms,
could
lead
severe
clinical
pathologies.
The
emergence
induced
pluripotent
stem
cells
(iPSCs)
has
revolutionized
field
regenerative
medicine,
providing
promising
platform
for
generating
various
cell
types
therapeutic
applications.
Thus,
chondrocytes
differentiated
iPSCs
become
avenue
non-invasive
interventions
diseases.
In
this
review,
we
aim
highlight
current
strategies
used
vitro
chondrogenic
differentiation
explore
their
multifaceted
applications
disease
modeling,
drug
screening,
personalized
medicine.
Achieving
abundant
functional
iPSC-derived
requires
optimization
culture
conditions,
incorporating
specific
growth
factors,
precise
temporal
control.
Continual
improvements
methods
integration
emerging
genome
editing,
organoids,
3D
bioprinting
technologies
will
enhance
translational
chondrocytes.
Finally,
unlock
benefits
patients
suffering
diseases
through
iPSCs-derived
chondrogenesis,
automatic
therapy
manufacturing
systems
only
reduce
human
intervention
ensure
sterile
processes
within
isolator-like
platforms
minimize
contamination
risks,
but
also
provide
customized
production
with
enhanced
scalability
efficiency.
Graphical
abstract
Current Therapeutic Research,
Journal Year:
2025,
Volume and Issue:
102, P. 100778 - 100778
Published: Jan. 1, 2025
Diabetic
wounds,
characterized
by
their
chronic
nature,
represent
a
critical
challenge
for
patients
with
diabetes,
often
leading
to
amputation
and
mortality.
Although
stem
cells
show
great
promise,
use
is
limited
challenges
related
stability
tumorigenicity.
The
secretome
of
cells,
comprising
molecules
released
these
offers
potential
alternative
the
associated
cell
therapy
provides
promising
solution
diabetic
wound
healing.
We
conducted
systematic
review
meta-analysis
relevant
preclinical
studies
evaluate
effectiveness
secretomes
in
treating
wounds.
protocol
registration
this
was
recorded
PROSPERO
database
(CRD42023473726).
Databases
were
searched
from
inception
until
November
20,
2023.
quality
assessment
included
performed
utilizing
CAMARADES
10-item
Quality
Checklist.
Statistical
analyses
using
random-effects
model
calculate
standardized
mean
differences
(SMD)
95%
confidence
intervals
(CI),
heterogeneity
assessed
via
I²
statistic.
primary
outcome
evaluated
closure
rate,
while
secondary
outcomes
parameters
such
as
number
fibroblasts,
neutrophils,
macrophages.
Twenty
included,
382
animal
subjects,
five
which
eligible
quantitative
evaluation
meta-analysis.
significantly
improved
rate
(SMD
=
9.63;
CI
2.01
-17.25;
P
0.01,
I2
76%)
reduced
neutrophils
-8.47;
-13.05
-3.90;
0.0003)
macrophages
-5.32;
-9.09
-1.55;
0.006).
This
suggests
that
have
novel
therapeutic
strategy
healing,
enhancing
rates
reducing
inflammation.
These
findings
support
safer
more
stable
direct
therapy,
but
further
clinical
are
needed
confirm
results
human
patients.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(3), P. 80 - 80
Published: Feb. 24, 2025
Polymer-based
scaffolds
have
emerged
as
transformative
materials
in
regenerative
dentistry,
enabling
the
restoration
and
replacement
of
dental
tissues
through
tissue
engineering
approaches.
These
scaffolds,
derived
from
natural
synthetic
polymers,
mimic
extracellular
matrix
to
promote
cellular
attachment,
proliferation,
differentiation.
Natural
polymers
such
collagen,
chitosan,
alginate
offer
biocompatibility
bioactivity,
while
alternatives
like
polylactic
acid
(PLA)
polycaprolactone
(PCL)
provide
tunable
mechanical
properties
degradation
rates.
Recent
advancements
highlight
integration
bioactive
molecules
nanotechnology
enhance
potential
these
materials.
Furthermore,
developing
hybrid
combining
addresses
strength
challenges,
paving
way
for
patient-specific
treatments.
Innovations
3D
bioprinting
stimuli-responsive
biomaterials
are
expected
refine
scaffold
design
further,
improving
therapeutic
precision
clinical
outcomes.
This
review
underscores
critical
role
polymer-based
advancing
focusing
on
their
applications,
advantages,
limitations.
Jentashapir Journal of Cellular and Molecular Biology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 13, 2025
Context:
Recent
advances
in
induced
pluripotent
stem
cells
(iPSCs),
CRISPR-Cas9
gene
editing,
nanotechnologies,
and
artificial
intelligence
have
revolutionized
regenerative
medicine
(RM)
as
a
transformative
field
for
tackling
difficult
medical
problems.
These
breakthroughs
promise
specific
treatments,
proper
restoration
of
tissue
function,
substantial
improvements
the
quality
life
patients
whose
ailments
cannot
yet
be
cured.
This
review
explores
cutting-edge
advancements
RM
platforms
such
cell
therapy,
3D
bioprinting,
nanotechnology.
The
study
also
aims
to
shed
light
on
challenges
clinical
translation
policy
implications,
which
are
crucial
fostering
sustainable
progressive
discipline.
Evidence
Acquisition:
manuscript
draws
research
development
application
technologies.
It
synthesizes
data
cells,
engineering,
vitro
organoid
industry,
(AI),
nanotechnology
that
illustrate
therapeutic
potential.
identify
ethical,
regulatory,
practical
hurdles
translating
from
practice.
Results:
Breakthroughs
those
iPSC-derived
organoids,
nanostructured
materials
exhibit
significant
preclinical
settings.
Platforms
organ-on-chip
AI
tools
further
enhance
drug
discovery
treatment
monitoring,
while
biomaterials
scaffold-based
approaches
repair
regeneration.
Nevertheless,
despite
these
advances,
persist
regarding
scale-up,
safety,
ethical
considerations.
Conclusions:
Innovations
represent
paradigm
shift
purely
symptomatic
treatments
restorative
therapies.
Successful
integration
into
practice
will
require
multidisciplinary
collaborative
work,
imposition
rigorous
safety
protocols,
enabling
regulatory
frameworks.
Addressing
would
enable
realize
its
true
potential
foundation
21st-century
healthcare.
Cell Regeneration,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Sept. 30, 2024
Abstract
Tissue
stem
cells
(TSCs),
which
reside
in
specialized
tissues,
constitute
the
major
cell
sources
for
tissue
homeostasis
and
regeneration,
contribution
of
transcriptional
or
epigenetic
regulation
distinct
biological
processes
TSCs
has
been
discussed
past
few
decades.
Meanwhile,
ATP-dependent
chromatin
remodelers
use
energy
from
ATP
hydrolysis
to
remodel
nucleosomes,
thereby
affecting
dynamics
gene
expression
programs
each
type.
However,
role
fate
determination
is
less
well
understood.
In
this
review,
we
systematically
discuss
recent
advances
control
by
hematopoietic
cells,
intestinal
epithelial
neural
skin
their
highlight
importance
essential
homeostasis,
development,
regeneration.
Moreover,
exploration
molecular
cellular
mechanisms
crucial
advancing
our
understanding
maintenance
discovery
novel
therapeutic
targets.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Nov. 18, 2024
After
experiencing
many
ups
and
downs,
chimeric
antigen
receptor
(CAR)-T
cell
therapy
has
reached
a
milestone
as
an
anti-cancer
method,
evidenced
by
the
increasing
number
of
clinical
trials
approved
products.
Nonetheless,
there
is
real
need
to
optimize
CAR-T
overcome
its
existing
limitations.
The
importance
cellular
starting
material
for
generating
cells
undeniable,
current
personalized
manufacturing
approach
main
roadblock
providing
fast,
affordable,
standard
treatment
patients.
Thus,
developing
off-the-shelf
product
leading
focus
in
adoptive
therapy.
Several
biotech
companies
worldwide
are
focused
on
from
allogeneic
sources.
Induced
pluripotent
stem
(iPSCs)
have
unique
characteristics,
making
them
highly
attractive
among
various
IPSCs
can
be
modified
with
CAR,
undergo
other
intended
gene
manipulations,
then
differentiated
into
functional
hematopoietic
lineages
activity.
Moreover,
iPSCs
provide
unlimited
source,
simplifying
setting
protocol
homogenous
population
resulting
reducing
batch-to-batch
inconsistency.
In
this
review,
we
delve
iPSC-derived
(iCAR-T)
discuss
path
challenges
their
translation.
We
also
introduce
some
alternatives
conventional
iCAR-αβ-T
cells,
including
iCAR-T
limited
TCR
diversity,
iCAR-NK,
iCAR-macrophages,
iCAR-neutrophils
relative
advantages
disadvantages
well
differentiation
compliance
cGMP.
Finally,
reviewed
CAR-engineered
being
evaluated
trials.
