Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Dependent Attenuation of Tear Hyperosmolarity and Immune Cell-Driven Inflammation in the Eyes of Patients with Dry Eye Disease DOI Creative Commons

Carl Randall Harrell,

Valentin Djonov, Ana Volarevic

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(11), P. 269 - 269

Published: Oct. 26, 2024

Background: Dry eye disease (DED) is a chronic condition characterized by decrease in tear production or an increase evaporation, leading to inflammation and damage of the ocular surface. Dysfunction ion channels, hyperosmolarity immune cell-driven create vicious circle responsible for pathological changes eyes DED patients. Mesenchymal stem cells (MSCs) are adult, rapidly proliferating that produce large number immunoregulatory, angiomodulatory, growth factors efficiently reduce hyperosmolarity-induced changes, inhibit harmful response, provide trophic support injured corneal conjuctival epithelial cells, goblet acinar lacrimal glands Methods: An extensive research literature was implemented order elucidate role MSCs attenuation patients suffering from DED. Results: Findings obtained preclinical pilot clinical studies demonstrated reduced hyperomsolaity-induced suppressed inflammation. Additionally, MSC-based therapy managed successfully address most severe DED-related conditions complications. Conclusions: should be considered as potentially new therapeutic agents treatment

Language: Английский

Advanced 3D Materials for Corneal Stroma Regeneration: A Preclinical Progress DOI
Amin Orash Mahmoud Salehi, Maryam Soleimani, Kevin Catzim-Ríos

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Corneal stromal defects cause global blindness and entail unmet solutions beyond transplants. This review highlights scaffolds, biomaterials, signaling cues in corneal stroma engineering to advance next-generation vision therapies.

Language: Английский

Citations

0
Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Dependent Attenuation of Tear Hyperosmolarity and Immune Cell-Driven Inflammation in the Eyes of Patients with Dry Eye Disease DOI Creative Commons

Carl Randall Harrell,

Valentin Djonov, Ana Volarevic

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(11), P. 269 - 269

Published: Oct. 26, 2024

Background: Dry eye disease (DED) is a chronic condition characterized by decrease in tear production or an increase evaporation, leading to inflammation and damage of the ocular surface. Dysfunction ion channels, hyperosmolarity immune cell-driven create vicious circle responsible for pathological changes eyes DED patients. Mesenchymal stem cells (MSCs) are adult, rapidly proliferating that produce large number immunoregulatory, angiomodulatory, growth factors efficiently reduce hyperosmolarity-induced changes, inhibit harmful response, provide trophic support injured corneal conjuctival epithelial cells, goblet acinar lacrimal glands Methods: An extensive research literature was implemented order elucidate role MSCs attenuation patients suffering from DED. Results: Findings obtained preclinical pilot clinical studies demonstrated reduced hyperomsolaity-induced suppressed inflammation. Additionally, MSC-based therapy managed successfully address most severe DED-related conditions complications. Conclusions: should be considered as potentially new therapeutic agents treatment

Language: Английский

Citations

1