Intelligent Generic High‐Throughput Oscillatory Shear Technology Fabricates Programmable Microrobots for Real‐Time Visual Guidance During Embolization DOI
Xuqi Peng,

Haitian Tang,

Zhenwen Zhao

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Microrobots for endovascular embolization face challenges in precise delivery within dynamic blood vessels. Here, an intelligent generic high‐throughput oscillatory shear technology (iGHOST) is proposed to fabricate diversely programmable, multifunctional microrobots capable of real‐time visual guidance vivo embolization. Leveraging machine learning (ML), key synthesis parameters affecting the success and sphericity are identified. Therefore, ML‐optimized iGHOST enables continuous production uniform with programmable sizes (400−1000 µm) at ultrahigh rate exceeding 240 mL h −1 by segmenting fluid into droplets before ionic cross‐linking, without requiring purification. Particularly, iGHOST‐fabricated magnetically responsive lipiodol‐calcium alginate (MagLiCA) highly distinguishable under X‐ray imaging, which allows navigation flows up 4 min accurate liver kidney vessels, thus addressing current issues. Crucially, MagLiCA possess drug‐loading capabilities, enabling simultaneous site‐specific treatment. The process intelligent, rapid, green manufacturing method, can produce size‐controllable, potential drug treatment imaging across various medical applications.

Language: Английский

Bacterial derivatives mediated drug delivery in cancer therapy: a new generation strategy DOI Creative Commons
Muhammad Ijaz,

Ikram Hasan,

Tamoor Hamid Chaudhry

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 24, 2024

Cancer is measured as a major threat to human life and leading cause of death. Millions cancer patients die every year, although burgeoning number researchers have been making tremendous efforts develop medicine fight against cancer. Owing the complexity heterogeneity cancer, lack ability treat deep tumor tissues, high toxicity normal cells, it complicates therapy However, bacterial derivative-mediated drug delivery has raised interest in overcoming restrictions conventional chemotherapy. In this review, we show various examples tumor-targeting bacteria derivatives for anticancer drugs. This review also describes advantages limitations delivering treatment drugs under regulated conditions employing these their membrane vesicles. study highlights substantial potential clinical translation bacterial-based carriers, improve work with other modalities, provide more powerful, dependable, distinctive therapy.

Language: Английский

Citations

7
Advancements in Micro/Nanorobots in Medicine: Design, Actuation, and Transformative Application DOI Creative Commons
Induni Nayodhara Weerarathna, Praveen Kumar, Hellen Yayra Dzoagbe

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5214 - 5250

Published: Feb. 4, 2025

In light of the ongoing technological transformation, embracing advancements that foster shared benefits is essential. Nanorobots, a breakthrough within nanotechnology, have demonstrated significant potential in fields such as medicine, where diagnostic and therapeutic applications are primary focus areas. This review provides comprehensive overview robots, their evolving role medical applications, particularly highlighting use nanorobots. Various design strategies operational principles, including sensors, actuators, nanocontrollers, discussed based on prior research. Key nanorobot include biomedical imaging, biosensing, minimally invasive surgery, targeted drug delivery, each utilizing advanced actuation technologies to enhance precision. The paper further examines recent progress micro/nanorobot addresses important considerations for future, biocompatibility, control, navigation, targeting, safety, ethical implications. offers holistic perspective how nanorobots can reshape practices, paving way precision medicine improved patient outcomes.

Language: Английский

Citations

0
Treatment of lung diseases via nanoparticles and nanorobots: Are these viable alternatives to overcome current treatments? DOI Creative Commons
Meekha George, Rabah Boukherroub,

Amitav Sanyal

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101616 - 101616

Published: Feb. 26, 2025

Language: Английский

Citations

0
Recyclable and well-dispersed Fe3O4@SiO2@polydopamine@Ag nanocomposite with enhanced photothermal effect for synergistic antibacteria effect DOI
Haiyang Zhuang, Xiaoyu Li, Xin Du

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161994 - 161994

Published: March 1, 2025

Language: Английский

Citations

0
Advanced Biomimetic and Biohybrid Magnetic Micro/Nano‐Machines DOI
Nandan Murali, Shashank Bhushan Das,

Satyam Yadav

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: May 16, 2024

Abstract Biomimetic and biohybrid micro/nano‐structures involve the replication creation of technologies, structures, materials based on biological systems at micrometer nanometer scale. These strategies harness natural principles to develop innovative treatment methods advanced microstructure devices for noninvasive therapies. In this study, a detailed overview fabrication processes, magnetically assisted locomotive techniques, potential applications biomimetic micro/nano‐machines are presented. The latest advancements in actuated such as annelid‐worm‐like microswimmers, jellyfish‐shaped microparticles, fish‐shaped walnut‐shaped micromotors explored. Additionally, magnetic systems, including sunflower seed‐based micro‐perforators, nanomotors extracted from bamboo stem, sperm cell‐based micromotors, bacteria‐based robots, scaffold‐based microrobots, DNA‐based microalgae‐based red blood microswimmers also examined. A thorough investigation behavior these Newtonian fluids, featuring cork‐screw motion, undulatory surface wrinkling traveling wave‐like ciliary stroke motion is discussed. Furthermore, unprecedented developed using minuscule cervical cancer tetrapod hybrid tissue regeneration silk fibroin protein‐based microscale scaffolds, doxorubicin drug delivery mushroom‐based microrobots extensively

Language: Английский

Citations

3
Water‐Stable Magnetic Lipiodol Micro‐Droplets as a Miniaturized Robotic Tool for Drug Delivery DOI
En Ren, Jing Hu, Ziyang Mei

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Magnetic microrobots, designed to navigate the complex environments of human body, show promise for minimally invasive diagnosis and treatment. However, their clinical adoption faces hurdles such as biocompatibility, precise control, intelligent tracking. Here a novel formulation (referred water-stable magnetic lipiodol micro-droplets, MLMD), integrating clinically approved lipiodol, gelatin, superparamagnetic iron oxide nanoparticles (SPION) with fundamental understanding structure-property relationships is presented. This demonstrates multiple improved properties including flowability, shape adaptability, efficient drug loading, compatibility digital subtraction angiography (DSA) imaging in both vitro vivo experiments. enables MLMD versatile tool image-guided therapy, supported by close-looped navigation system featuring artificial intelligence (AI)-driven visual feedback autonomous control. The effectively performs navigational tasks, pinpointing specific locations MLMD, recognizing avoiding obstacles, mapping following predetermined paths, utilizing fields motion planning achieve delivery. combines actuation an AI-directed navigation, offering transformative platform targeted therapeutic

Language: Английский

Citations

2
Intelligent Generic High‐Throughput Oscillatory Shear Technology Fabricates Programmable Microrobots for Real‐Time Visual Guidance During Embolization DOI
Xuqi Peng,

Haitian Tang,

Zhenwen Zhao

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Microrobots for endovascular embolization face challenges in precise delivery within dynamic blood vessels. Here, an intelligent generic high‐throughput oscillatory shear technology (iGHOST) is proposed to fabricate diversely programmable, multifunctional microrobots capable of real‐time visual guidance vivo embolization. Leveraging machine learning (ML), key synthesis parameters affecting the success and sphericity are identified. Therefore, ML‐optimized iGHOST enables continuous production uniform with programmable sizes (400−1000 µm) at ultrahigh rate exceeding 240 mL h −1 by segmenting fluid into droplets before ionic cross‐linking, without requiring purification. Particularly, iGHOST‐fabricated magnetically responsive lipiodol‐calcium alginate (MagLiCA) highly distinguishable under X‐ray imaging, which allows navigation flows up 4 min accurate liver kidney vessels, thus addressing current issues. Crucially, MagLiCA possess drug‐loading capabilities, enabling simultaneous site‐specific treatment. The process intelligent, rapid, green manufacturing method, can produce size‐controllable, potential drug treatment imaging across various medical applications.

Language: Английский

Citations

0