Food Chemistry, Journal Year: 2025, Volume and Issue: 477, P. 143570 - 143570
Published: Feb. 23, 2025
Language: Английский
Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 142, P. 108784 - 108784
Published: May 1, 2023
Over the years, seaweeds have been highlighted as valuable natural sources of bioactive polysaccharides. Fucoidan, a sulphated polysaccharide mainly from brown composed fucopyranose backbone and several monosaccharides, reported to possess numerous biological activities such anticancer, antioxidant, immunoregulatory, antiviral, antithrombic, anti-inflammatory properties thus may confer health benefits humans. However, main mechanisms bridging structural complexity fucoidans their activity are mostly ignored. This review provides an update on current knowledge green extraction methods, purification, analysis fucoidan. Factors influencing fucoidan also discussed. Lastly, presents concise information about application in food industry, its utilization delivery systems for nutraceuticals prospects designing functional foods, well toxicological concerns associated with use fucoidans. The is dependent species, source, harvesting time, among other factors. turn greatly influences fucoidans, high degree sulphation low molecular weight particularly linked increased activity. Due presence sulphate moieties, easily interact polymers far-reaching applications.
Language: Английский
Citations
78
Bioprinting, Journal Year: 2023, Volume and Issue: 33, P. e00291 - e00291
Published: June 16, 2023
Language: Английский
Citations
24
Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 27 - 27
Published: Jan. 7, 2025
Fucoidan is a sulfated polysaccharide found in brown seaweed. Due to its reported biological activities, including antiviral, antibacterial and anti-inflammatory it has garnered significant attention for potential biomedical applications. However, the direct relationship between fucoidan extracts' chemical structures bioactivities unclear, making extremely challenging predict whether an extract will possess given bioactivity. This further complicated by lack of uniformity recent literature terms assessment reporting properties, yield composition (e.g., sulfate, fucose, uronic acid monosaccharide contents). These inconsistencies pose challenges when directly comparing extraction techniques across studies. review collected data on contents properties from selection available Where information was unavailable directly, efforts were made extrapolate data. approach enabled comprehensive examination correlation characteristics resulting extracts. A holistic framework presented methods, outlining key heuristics consider capturing broader context seaweed bioprocess. Future work should focus developing knowledge within these heuristic categories, such as creation technoeconomic models each process. allow robust process that integrates scale, cost constraints into decision making. Key quality attributes biologically active are proposed, areas future research identified, studies specific aimed at elucidating fucoidan's mechanism action. also sets out required standardize Standardization could positively enhance depth extracts, enabling relationships physical, bioactive be identified. Recommendations best practices production high-quality with desirable yield, bioactivity highlighted.
Language: Английский
Citations
1
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123468 - 123468
Published: March 1, 2025
Language: Английский
Citations
1
Marine Drugs, Journal Year: 2023, Volume and Issue: 21(1), P. 43 - 43
Published: Jan. 5, 2023
Alzheimer’s disease (AD), a neurodegenerative disease, is one of the most intractable illnesses which affects elderly. Clinically manifested as various impairments in memory, language, cognition, visuospatial skills, executive function, etc., symptoms gradually aggravated over time. The drugs currently used clinically can slow down deterioration AD and relieve but cannot completely cure them. are mainly acetylcholinesterase inhibitors (AChEI) non-competitive N-methyl-D-aspartate receptor (NDMAR) antagonists. pathogenesis inconclusive, it often associated with expression beta-amyloid. Abnormal deposition amyloid hyperphosphorylation tau protein brain have been key targets for past, current, future drug development disease. At present, researchers paying more attention to excavate natural compounds be effective against other pathologies. Marine products demonstrated prospective candidates these compounds, some presented significant neuroprotection functions. Consequently, we intend describe potential effect bioactive derived from marine organisms, including polysaccharides, carotenoids, polyphenols, sterols alkaloids candidates, further discover novel efficacious AD.
Language: Английский
Citations
21
Drug Delivery and Translational Research, Journal Year: 2023, Volume and Issue: 13(10), P. 2427 - 2446
Published: April 3, 2023
Language: Английский
Citations
21
Future Foods, Journal Year: 2024, Volume and Issue: 10, P. 100440 - 100440
Published: Aug. 23, 2024
Seaweeds are incredibly significant marine resources that have the ability to yield beneficial metabolites and bioactive substances, exhibiting an extensive variety of biological physiological capabilities. Seaweed polysaccharides, in conjunction with other components, been shown exhibit a diverse range advantageous characteristics. These include antioxidant, anticoagulant, anti-inflammatory, antiviral, anticarcinogenic effects. The assortment constitution polysaccharides found seaweed crucial factors regulating these processes. Agar, alginate, carrageenan, fucoidan, ulvan abundant seaweeds, boosting their bioactivity. Tissue engineering, drug administration, wound healing among medical applications polysaccharides. Algae-derived exhibited extraordinary antiviral properties, which makes them highly promising subjects for pharmacological research. Moreover, numerous mechanisms recorded encompassing prevention viral coupling or entry cell host, along inhibition DNA replication protein synthesis. also potential serve as long-term solution against publicized coronavirus, has caused global pandemic. This review aims analyze seaweed-derived explore association between bioactivity structural compositions, highlight applications, particularly relation activity.
Language: Английский
Citations
8
Frontiers in Marine Science, Journal Year: 2024, Volume and Issue: 11
Published: April 24, 2024
Fucoidan (Fuc) is a sulfated polysaccharide derived from brown algae and has various biological activities such as immune modulator, growth enhancer, antioxidant bactericidal. However, there no information about the effect of fucoidan on ornamental fish. This study investigated Sargassum ilicifolium parameters, immunity, biochemical, antioxidant, bactericidal activity serum in Oscar. Fish weighing 49.75 ± 0.96 g were fed S. at four levels (0%, 0.5%, 1%, 2%) for 50 days. After days feeding with fucoidan, was significant increase blood parameters except WBCs (Fuc compared to control group ( p < 0.05). The weight gain (WG), feed conversion ratio (FCR), specific rate (SGR) after had Serum biochemical total protein (Tp) globulin (Glb) groups 0.05), but difference observed albumin (Alb) > Antioxidant serum, SOD CAT, In addition, lysozyme complement containing significantly increased A NBT against Aeromonas hydrophila Fuc 2% skin carotenoids 1% Overall, it can be concluded that parameters. could pigmentation, enzyme activity, A. .
Language: Английский
Citations
7
Foods, Journal Year: 2023, Volume and Issue: 12(13), P. 2600 - 2600
Published: July 5, 2023
Diabetes mellitus (DM) has become the world’s third major disease after tumors and cardiovascular disease. With exploitation of marine biological resources, efficacy using polysaccharides isolated from organisms in blood glucose regulation received widespread attention. Some can reduce by inhibiting digestive enzyme activity, eliminating insulin resistance, regulating gut microbiota. These are mainly fucose-containing sulphated algae sea cucumbers. It follows that hypoglycemic activity fucosyl-polysaccharides is closely related to their structure, such as sulfate group, monosaccharide composition, molecular weight glycosidic bond type. However, structure mechanism not yet clear. Therefore, this review comprehensively covers effects sources, mechanisms structure–activity relationship on activity. Moreover, potential regulatory vascular complications caused hyperglycemia also summarized review. This provides rationales for study new insights into high-value utilization resources.
Language: Английский
Citations
14
ALGAE, Journal Year: 2023, Volume and Issue: 38(4), P. 217 - 240
Published: Dec. 15, 2023
Sulfated polysaccharides (SPs) isolated from seaweed have emerged as remarkable bioactive compounds with a wide spectrum of biological activities and substantial value in the scientific industrial domains. The current study explores diverse SPs their relationship structures. This aids an in-depth examination multifaceted SPs, including anticoagulant, anti-inflammatory, antiviral, antioxidant, immunomodulatory properties, which underpin potential health benefits. Furthermore, complicated properties extraction methodologies techniques for precise characterization. Elucidation commercial significance derived brown, red, green by highlighting applications has emphasized importance human well-being. Further, this review emphasizes challenges needed to overcome research innovations SPs. Collaboration among researchers, industry stakeholders, regulatory authorities can these elevate revolutionize industries such pharmaceuticals, cosmeceuticals, food, biotechnology.
Language: Английский
Citations
13