Advances in orthopedic implants: the role of nanotechnology in enhancing performance and longevity

Regenerative medicine reports ., Journal Year: 2025, Volume and Issue: 2(1), P. 15 - 21

Published: Feb. 6, 2025

Traditional orthopedic implants, despite being broadly accepted, come with numerous limitations such as low osseointegration, mechanical wear, and vulnerability to infection, thus causing complications consequent revision surgeries. Nanotechnology provides an innovative approach materials at the nanoscale, enhancing efficacy of implants used. This necessitates development that respond human movement, demonstrate greater durability, can be used for extended periods. Nanostructured surfaces coatings mimic conditions natural bone, promoting superior cell adhesion, proliferation, differentiation, which are essential both successful osseointegration bone regeneration. Moreover, use nanocoatings exhibit outstanding antibacterial properties, thereby reducing risk postoperative infections. Each component in a nanocomposite, ceramics, polymers, metals, contributes excellent performance stability effectively addressing issues related implant wearing failure. In addition, nanotechnology also facilitates incorportion drug delivery systems within allowing localized controlled release antibiotics or growth factors. targeted enhances healing minimizes side effects other parts body. Despite its capability transformation, challenges scalability manufacturing, potential toxicity, immunogenic responses, regulatory approval processes remain. review focuses on applications highlighting how these have impacted efficacy, strength, delivery. offers promising improving patient care better, complications, transforming future orthopedics. To fully realize potential, it is investigate current explore new areas research.

Language: Английский

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Nanoparticles in Bone Regeneration: A Narrative Review of Current Advances and Future Directions in Tissue Engineering

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(9), P. 241 - 241

Published: Aug. 23, 2024

The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, composites their potential enhance osteogenesis angiogenesis by mimicking extracellular matrix (ECM) nanostructure. involved synthesizing characterizing nanoparticle-based scaffoldsand integrating hydroxyapatite (HAp) with polymers mechanical properties osteogenic potential. results showed that NPs significantly promote cell growth, differentiation, formation, carbon-based graphene carbon nanotubes showing promise. offer versatile, biocompatible, customizable scaffolds drug delivery support repair. Despite promising results, challenges cytotoxicity, biodistribution, immune responses remain. Addressing issues through surface modifications biocompatible molecules can improve biocompatibility efficacy nanomaterials. Future research should focus on long-term vivo studies assess safety NP-based explore synergistic effects other bioactive or growth factors. underscores transformative advancing BTE calls further optimize technologies clinical applications.

Language: Английский

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Dual-functional Hydroxyapatite scaffolds for bone regeneration and precision drug delivery

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 157, P. 106661 - 106661

Published: July 14, 2024

Language: Английский

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Piezoelectric Scaffolds as Smart Materials for Bone Tissue Engineering

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2797 - 2797

Published: Oct. 2, 2024

Bone repair and regeneration require physiological cues, including mechanical, electrical, biochemical activity. Many biomaterials have been investigated as bioactive scaffolds with excellent electrical properties. Amongst biomaterials, piezoelectric materials (PMs) are gaining attention in biomedicine, power harvesting, biomedical devices, structural health monitoring. PMs unique properties, such the ability to affect movements deliver stimuli damaged bone or cells without an external source. The crucial property is its piezoelectricity. Bones can generate charges potential response mechanical stimuli, they influence growth regeneration. Piezoelectric respond human microenvironment important factor repair. This manuscript overview of fundamentals generating effect their on paper focuses state art materials, polymers, ceramics, composites, application tissue engineering. We present information from point view highlight promising upcoming approaches new generations materials.

Language: Английский

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Three-Dimensional Printing/Bioprinting and Cellular Therapies for Regenerative Medicine: Current Advances

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 28 - 28

Published: Jan. 16, 2025

The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field regenerative medicine. This paper aims provide a comprehensive overview 3D technology therapies, highlighting results diverse medical applications, while also discussing capabilities limitations combined use. synergistic combination printing cellular been recognised as promising innovative approach, it is expected that these will progressively assume crucial role treatment various diseases conditions foreseeable future. review concludes with forward-looking perspective on future impact technologies, revolutionize medicine through enhanced tissue repair organ replacement strategies.

Language: Английский

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Phytonanoparticles as novel drug carriers for enhanced osteogenesis and osseointegration

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 16, 2025

Abstract Phytonanoparticles have emerged as a promising class of biomaterials for enhancing bone regeneration and osseointegration, offering unique advantages in biocompatibility, multifunctionality, sustainability. This comprehensive review explores the synthesis, characterization, applications phytonanoparticles tissue engineering. The green synthesis approach, utilizing plant extracts reducing stabilizing agents, yields nanoparticles with intrinsic bioactive properties that can synergistically promote osteogenesis. We examine mechanisms by which phytonanoparticles, particularly those derived from gold, silver, zinc oxide, influence key molecular pathways osteogenesis, including RUNX2 Osterix signaling. discusses advanced strategies phyto-nanoparticle design, such surface functionalization stimuli-responsive release mechanisms, enhance their efficacy applications. Preclinical studies demonstrating improved osteoblast proliferation, differentiation, mineralization are critically analyzed, along emerging clinical data. Despite results, scalability, standardization, regulatory approval challenges persist. also addresses economic environmental implications production. Looking ahead, we identify research directions, developing personalized therapies, combination approaches stem cells or gene delivery, long-term safety assessments. By harnessing power plant-derived nanomaterials, represent an innovative approach to addressing complex regeneration, potential spanning dental, orthopedic, maxillofacial surgery. Graphical abstract

Language: Английский

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Probiotics and nanoparticle-mediated nutrient delivery in the management of transfusion-supported diseases

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 11, 2025

Bone marrow is vital for hematopoiesis, producing blood cells essential oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy stem cell transplants, have significantly improved patient outcomes but are often associated with severe side effects limitations, necessitating the exploration of safer, more targeted therapeutic strategies. Nanotechnology has emerged as a promising approach addressing these challenges, particularly in delivery nutraceuticals—bioactive compounds derived from food sources potential benefits. Despite their promise, nutraceuticals face clinical limitations due poor bioavailability, instability, inefficient target sites. Nanoparticles offer viable solution by enhancing stability, absorption, transport bone while minimizing systemic effects. This study explores range disorders, conventional treatment modalities, nanoparticles enhance nutraceutical-based therapies. By improving efficacy, could revolutionize disease management, providing patients effective less invasive options. These advancements represent significant step toward safer efficient approaches, ultimately prognosis overall health.

Language: Английский

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A review of self-healing hydrogels for bone repair and regeneration: Materials, mechanisms, and applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138323 - 138323

Published: Dec. 1, 2024

Language: Английский

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Nanostructures in Orthopedics: Advancing Diagnostics, Targeted Therapies, and Tissue Regeneration

Materials, Journal Year: 2024, Volume and Issue: 17(24), P. 6162 - 6162

Published: Dec. 17, 2024

Nanotechnology, delving into the realm of nanometric structures, stands as a transformative force in orthopedics, reshaping diagnostics, and numerous regenerative interventions. Commencing with this scientific discipline empowers accurate analyses various diseases implant stability, heralding an era unparalleled precision. Acting carriers for medications, nanomaterials introduce novel therapeutic possibilities, propelling field towards more targeted effective treatments. In arthroplasty, nanostructural modifications to surfaces not only enhance mechanical properties but also promote superior osteointegration durability. Simultaneously, nanotechnology propels tissue regeneration, nanostructured dressings emerging pivotal elements accelerating wound healing. As we navigate frontiers nanotechnology, ongoing research illuminates promising avenues further advancements, assuring future where orthopedic practices are personalized highly efficient, captivating journey through groundbreaking innovations tailored patient care.

Language: Английский

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Editorial for the Special Issue on “Multidisciplinary Insights on Bone Healing (Volume II)”

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 32 - 32

Published: Jan. 3, 2025

As the population ages and differences among sexes age groups become more pronounced, research on bone healing damage mechanisms continues to advance, with evaluation conducted in both pre-clinical clinical settings [...].

Language: Английский

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