Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs
Xing Wan,
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Jingyuan Ma,
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He Bai
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et al.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(1), P. 140 - 140
Published: Jan. 17, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
become
the
most
common
chronic
and
is
closely
associated
with
metabolic
diseases
such
as
obesity,
type
2
diabetes
mellitus
(T2DM),
syndrome.
However,
effective
treatment
strategies
for
NAFLD
are
still
lacking.
In
recent
years,
progress
been
made
in
understanding
pathogenesis
of
NAFLD,
identifying
multiple
therapeutic
targets
providing
new
directions
drug
development.
This
review
summarizes
advances
focusing
on
mechanisms
action
natural
products,
small-synthetic-molecule
drugs,
combination
therapy
strategies.
aims
to
provide
insights
treating
NAFLD.
Language: Английский
Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols
Raissa Bulaty Tauil,
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Paula Takano Golono,
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Enzo Pereira de Lima
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et al.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(10), P. 1354 - 1354
Published: Oct. 10, 2024
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
clinical-pathological
scenario
that
occurs
due
to
the
accumulation
of
triglycerides
in
hepatocytes
which
considered
significant
cause
liver
conditions
and
contributes
an
increased
risk
death
worldwide.
Even
though
possible
causes
MAFLD
can
involve
interaction
genetics,
hormones,
nutrition,
lifestyle
(diet
sedentary
lifestyle)
most
influential
factor
developing
this
condition.
Polyphenols
comprise
many
natural
chemical
compounds
be
helpful
managing
metabolic
diseases.
Therefore,
aim
review
was
investigate
impact
oxidative
stress,
inflammation,
mitochondrial
dysfunction,
role
polyphenols
MAFLD.
Some
reverse
part
damage
related
or
among
them
are
anthocyanin,
baicalin,
catechin,
curcumin,
chlorogenic
acid,
didymin,
epigallocatechin-3-gallate,
luteolin,
mangiferin,
puerarin,
punicalagin,
resveratrol,
silymarin.
These
have
actions
reducing
plasma
enzymes,
body
mass
index,
waist
circumference,
adipose
visceral
indices,
lipids,
glycated
hemoglobin,
insulin
resistance,
HOMA
index.
They
also
reduce
nuclear
factor-KB
(NF-KB),
interleukin
(IL)-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α),
blood
pressure,
fat
content,
steatosis
fibrosis.
On
other
hand,
they
improve
HDL-c,
adiponectin
levels,
fibrogenesis
markers.
results
show
promising
prevention
treatment
Language: Английский
Hepatoprotective activity of Taraxacum officinale extract against CCl4-induced Liver injury in rats
Food Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106708 - 106708
Published: April 1, 2025
Language: Английский
Dapagliflozin: A Promising Strategy to Combat Cisplatin-Induced Hepatotoxicity in Wistar Rats
Biology,
Journal Year:
2024,
Volume and Issue:
13(9), P. 672 - 672
Published: Aug. 29, 2024
Recognizing
the
challenges
posed
by
chemotherapy,
specifically
hepatotoxic
effects
of
drugs
like
cisplatin,
this
study
aimed
to
examine
hepatoprotective
potential
dapagliflozin
mitigate
cisplatin-induced
hepatotoxicity
in
a
rat
model.
This
focused
on
repurposing
such
as
and
natural
agents
silymarin
interventions
address
hepatotoxicity.
Thirty
adult
female
Wistar
rats
were
distributed
into
five
groups
treated
with
cisplatin
alone,
silymarin,
dapagliflozin,
or
combination
accordingly
for
45
days.
Body
weight,
fasting
blood
glucose
levels,
liver
function
tests,
histopathological
analysis
conducted
evaluate
effects.
Cisplatin-induced
significantly
(
Language: Английский