Journal of Neurochemistry,
Journal Year:
2025,
Volume and Issue:
169(3)
Published: March 1, 2025
ABSTRACT
Despite
being
classified
as
neurodevelopmental
disorders,
in
recent
years,
there
has
been
a
growing
interest
the
association
between
autism
spectrum
disorders
(ASDs)
and
gut
pathology.
This
comprehensive
systematic
review
explores
potential
mechanism
underlying
pathology
ASDs,
including
alterations
microbiota,
intestinal
permeability,
immune
dysregulation,
gastrointestinal
(GI)
symptoms.
Specifically,
it
delves
into
role
of
toxic
essential
metals
their
interplay,
affecting
development
function
GI
tract.
The
also
discusses
implications
this
management
ASDs.
Studies
have
shown
that
heavy
metal
exposure,
whether
through
environmental
sources
or
dietary
intake,
can
disrupt
delicate
balance
trace
elements
gut.
disruption
adversely
affect
zinc
homeostasis,
potentially
exacerbating
individuals
with
impaired
absorption
resulting
from
exposure
may
contribute
to
oxidative
stress,
inflammation
observed
By
shedding
light
on
multifaceted
nature
pathology,
impact
dyshomeostasis
non‐genetic
factor
ASD,
underscores
significance
gut‐brain
axis
etiology
image
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(11), P. 6082 - 6082
Published: May 29, 2022
Epidemiological
studies
have
shown
a
clear
association
between
early
life
zinc
deficiency
and
Autism
Spectrum
Disorders
(ASD).
In
line
with
this,
mouse
models
revealed
prenatal
as
profound
risk
factor
for
neurobiological
behavioral
abnormalities
in
the
offspring
reminiscent
of
ASD
behavior.
From
these
studies,
complex
pathology
emerges,
alterations
gastrointestinal
immune
system
synaptic
signaling
brain,
major
consequence
deficiency.
The
features
represent
critical
link
causal
chain
that
leads
to
various
neuronal
dysfunctions
phenotypes
observed
deficient
(PZD)
mice
probably
other
ASD.
Given
complete
phenotype
PZD
may
be
key
understanding
how
non-genetic
factors
can
modify
clinical
severity
autistic
patients
explain
heterogeneity,
here,
we
summarize
published
data
on
mice.
We
critically
review
emerging
evidence
is
at
core
several
environmental
associated
ASD,
being
mechanistically
linked
ASD-associated
genetic
factors.
addition,
highlight
future
directions
outstanding
questions,
including
potential
symptomatic,
disease-modifying,
preventive
treatment
strategies.
BMC Pregnancy and Childbirth,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: May 19, 2023
Abstract
Objective
The
present
study
explored
the
relationship
between
maternal
copper
and
zinc
levels
preterm
labor.
Design
design
of
was
a
case-control.
Two
groups
were
matched
in
terms
early-pregnancy
body
mass
index
(BMI),
pregnancy
childbirth
rating,
education
level,
income,
employment
status.
Blood
samples
taken
from
mothers
after
meeting
inclusion
criteria
when
admitted
to
maternity
ward
check
serum
levels.
Demographic
midwifery
data
also
collected
using
questionnaire
patient
records.
analyzed
SPSS26
independent-samples
T-test,
chi-square,
Fisher
exact
test,
regression
analysis,
p
<
0.05
considered
statistically
significant.
Setting
Bohloul
Hospital
Gonabad,
Iran.
Participants
subjects
86
pregnant
women
visiting
hospital
two
cases
(preterm
delivery)
control
(term
groups.
Results
mean
level
case
group
(44.97
±
13.06
µg/dl)
significantly
lower
than
(term)
(52.63
21.51
µg/dl),
(149.82
53.13
(183.97
71.40
µg/dl).
Conclusion
As
findings
showed,
with
delivery
term
delivery,
which
shows
biological
role
these
elements
pathogenesis
delivery.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(20), P. 6519 - 6519
Published: Oct. 14, 2023
Postpartum
depression
(PPD)
is
a
disorder
that
impairs
the
formation
of
relationship
between
mother
and
child,
reduces
quality
life
for
affected
women
to
functionally
significant
degree.
Studying
markers
associated
with
PPD
can
help
in
early
detection,
prevention,
or
monitoring
treatment.
The
purpose
this
paper
review
biomarkers
linked
present
selected
theories
on
pathogenesis
disease
based
data
from
biomarker
studies.
complex
etiology
specificity
sensitivity
markers,
but
they
remain
valuable
source
information
clinicians.
biggest
challenge
future
will
be
translate
high-tech
methods
detecting
postpartum
into
more
readily
available
less
costly
ones.
Population-based
studies
are
needed
test
utility
potential
markers.
Food systems,
Journal Year:
2025,
Volume and Issue:
7(4), P. 568 - 574
Published: Feb. 3, 2025
The
prospects
of
using
some
chelated
forms
zinc
to
develop
new
enriched
food
products
are
substantiated
in
the
work.
authors
give
a
brief
description
synthesis
double
forms:
Zn
diglycinate,
pantothenate-glycinate,
thiaminate-glycinate,
citrate,
cysteinate-glycinate.
Synthesis
chelates
included
stages
treatment
compounds
with
amino
acids
and
vitamins
partial
heating,
as
well
ultrasound
at
frequency
25
kHz
create
micro-nanoparticles
accelerate
formation
chelates.
Authenticity
obtained
was
determined
IR
spectroscopy
by
comparison
reference
databases.
ability
not
form
insoluble
when
adding
systems
examined
on
several
groups:
bakery
products,
multi-fruit
juice-containing
beverages,
fermented
(kefir
whey-containing
beverages),
meat
processing
sugary
confectionary
products.
Preservation
soluble
method
direct
extractive
titration
use
metallochromic
indicator
dithizone
following
photocolorimetry
visible
spectrum
(530–550
nm)
medium
carbon
tetrachloride
or
hexane.
be
extracted
from
system
for
increased
order:
whey-based
beverages
<
bread
containing
phytic
beverage
yogurt,
including
yogurt
fruit
filling
marmalade
based
agar-agar
other
confectionery
similar
consistency
raw
materials.
data
indicate
significant
developing
satisfy
needs
groups
population
this
microelement.
