Low-dose bisphenols exposure sex-specifically induces neurodevelopmental toxicity in juvenile rats and the antagonism of EGCG

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132074 - 132074

Published: July 17, 2023

Language: Английский

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Dietary phytochemicals: As a potential natural source for treatment of Alzheimer's Disease

Food Innovation and Advances, Journal Year: 2023, Volume and Issue: 2(1), P. 36 - 43

Published: Jan. 1, 2023

Alzheimer's disease (AD) is a common neurodegenerative disease, which seriously impairs human health and life. At present, scientists have proposed more than dozen hypotheses about the pathogenesis of AD, including tau propagation hypothesis. However, exact ultimate pathogenic factor AD remains unknown. Based on current hypotheses, some anti-AD drugs (e.g., donepezil Ketamine) been developed used in clinical treatment, fall into two main categories, acetylcholinesterase inhibitors (AChEIs) N-methyl-D-aspartate (NMDA) receptor antagonists, former representative drug donepezil, latter memantine. Since these undesirable side effects, it necessary to find safer alternatives for treatment. Interestingly, dietary phytochemicals advantages wide source, safety, high biological activity, natural route screening drugs. In this study, several representatives' with effect, resveratrol, lycopene, gallic acid, berberine, ginsenoside Rg1, pseudoginsenoside-F11, Rh2, artemisinin, torularhodin were selected from published data over last 10 years their potential molecular mechanisms applications reviewed treatment AD.

Language: Английский

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Neuroinflammation, Its Role in Alzheimer’s Disease and Therapeutic Strategies

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Neuroinflammation precedes the clinical onset of various neurodegenerative diseases, including Alzheimer's disease (AD), by years or frequently even decades (1-3). In terms underlying physiology, there is a great need for understanding and controlling interactions between central nervous system (CNS) immune in an attempt to develop approaches prevent delay disease's progression. Nerve cells have limited motion capability, whereas can migrate freely via circulation. This difference raises variety questions context senile plaque formation phagocytosis. Broad-scale unbiased genomic studies bring several genetic variants such as sialic acid binding Ig-like lectin 3 (CD33), triggering receptor expressed on myeloid 2 (TREM2) complement type 1 (CR1) into focus researchers' attention potential risk factors neuroinflammation. addition, advanced proteomic analyses been revealing links these contributors complex, malfunctioning signaling pathways (including upregulation like tumor necrosis factor TNF-α, growth TGF-β interleukin IL-1α) that promote proinflammatory mechanisms intracellular trafficking, synaptic function, cell metabolism/ proliferation. AD, brain's microglia astrocytes, which are normally responsible maintaining homeostasis transmission its remodeling pruning, initiators neuroinflammation toxic tau amyloid-β (Aβ) accumulation. Thus, they drive CNS state sustained self-accelerated deterioration. Here we aim review types mediators involved symptom manifestation settings, candidates improving diagnosis treatment.

Language: Английский

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Mitochondrial mechanisms in Alzheimer’s disease: Quest for therapeutics

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(5), P. 103547 - 103547

Published: March 5, 2023

Language: Английский

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Controlled oxidation and digestion of Pickering emulsions stabilized by quinoa protein and (-)-epigallocatechin-3-gallate (EGCG) hybrid particles

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126755 - 126755

Published: Sept. 6, 2023

Language: Английский

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