Amygdalin’s neuroprotective effects on acute ischemic stroke in rats

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119621 - 119621

Published: March 1, 2025

Language: Английский

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Analytical Strategies for Green Extraction, Characterization, and Bioactive Evaluation of Polyphenols, Tocopherols, Carotenoids, and Fatty Acids in Agri-Food Bio-Residues

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1326 - 1326

Published: March 15, 2025

Recent advancements in analytical strategies have enabled the efficient extraction and characterization of bioactive compounds from agri-food bio-residues, emphasizing green chemistry circular economy principles. This review highlights valorization several bio-residues for high-value-added compounds, particularly polyphenols, tocopherols, carotenoids, fatty acids, as a biorefinery approach. To this end, adoption environmentally friendly technologies is essential to improve performance, reduce energy consumption, minimize costs. study therefore examines emerging methodologies such supercritical fluid extraction, pressurized liquid pulsed electric fields, matrix solid-phase dispersion, highlighting their advantages limitations. Additionally, chemical these explored through spectrophotometric high-resolution chromatographic techniques, crucial accurate identification quantification. complemented by an analysis bioactivity assays evaluating antioxidant, antimicrobial, anticancer, neuroprotective, anti-inflammatory properties, with focus on applications food, pharmaceutical, cosmetic industries. However, control toxic alkaloids, undoubtedly needed. Ultimately, approach not only promotes sustainability but also contributes development eco-friendly solutions various

Language: Английский

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The protective and chemotherapeutical role of amygdalin in induced mammary cancer in experimental mice and upregulation of related genes

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 17, 2025

Abstract Breast cancer is a prominent health issue among oncological diseases in emerging nations. The study sought to assess the significant function of amygdalin as protective and chemotherapeutical substance combating this lethal condition, either independently or conjunction with tamoxifen therapy. mice was induced by 7,12-Dimethylbenz(a)anthracene (DMBA). Mice were divided into six groups, 15 each group. (i) control group, (ii) carcinogenic (iii) tamoxifen-treated (iv) Amygdalin-treated (v) (Amygdalin + tamoxifen) (vi) Amygdalin Results revealed that DMBA-induced breast caused increase biochemical parameters such CEA, CA15.3, CA125, PRL, E2, urea, creatinine, ALT, AST, ALP substantial gene expression TNF-α BcL-2. In contrast, administrations alone co-administration could ameliorate declining TNF-α, BcL-2 attenuating parameters. showed SOD GPx antioxidants upregulation Caspase-3 P53 tissue. Moreover, flow cytometric analysis correlated CD20 CD44 promoted cell cycle apoptosis mice. Indeed, above results confirmed histopathological examinations, which DMBA group had proliferated microductular carcinoma marked mononuclear inflammatory infiltration, decreased administrations. conclusion, administration may be effective preventing exhibiting chemotherapeutic properties.

Language: Английский

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Exploring the Physicochemical Properties of Amygdalin in Selected Solvents: Insights from Molecular Simulation

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127472 - 127472

Published: March 1, 2025

Language: Английский

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Investigation of the ameliorative effects of amygdalin against arsenic trioxide-induced cardiac toxicity in rat

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106795 - 106795

Published: April 8, 2025

Language: Английский

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Assessment of suitable habitat of Semen Armeniacae Amarum. in China under different climatic conditions by Internal Transcribed Spacer 2 and Maxent model

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

The Chinese Pharmacopoeia stipulates that the dried ripe seeds of these four plants (Prunus armeniaca L. var. ansu Maxim., Prunus sibirica L., mandshurica (Maxim.) Koehne, and L.) can all be used as Semen Armeniacae Amarum. Amygdalin is widely recognized a key quality marker for standardizing It exhibits notable antitussive antiasthmatic effects, believed to relieve cough by modulating activity respiratory center. Its diverse pharmacological properties position it potential lead compound in drug discovery development novel therapeutics. Climate change has significant impact on its species distribution accumulation bioactive components. In this study, site information plant was collected through field surveys online data surveys. Using Internal Transcribed Spacer 2 (ITS2), attribution bitter almonds each from different geographical region identified amygdalin content measured. maximum entropy model coupled with stepwise regression equation evaluate future climate amygdalin. results showed 26 samples producing areas were PS. Under various scenarios (RCP2.6, RCP4.5, RCP8.5), projected ranges PS PA are predicted contract, whereas range PK expand slightly. PM expected either or depending specific timeframes. Specifically, an expansion under RCP2.6 both 2050s 2070s, RCP8.5 2050s. Conversely, contraction RCP4.5 2070s. From perspective secondary metabolism, strong positive correlation temperature precipitation. These findings provide valuable guidance optimizing traditional medicine supply chains formulating targeted conservation strategies medicinal resources.

Language: Английский

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Alleviating penicillin-resistant Streptococcus pneumoniae‑induced lung epithelial cell injury: mechanistic insights into effects of the optimized combination of main components from Yinhuapinggan granules

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 20, 2025

Penicillin-resistant Streptococcus pneumoniae (PRSP), for which novel treatment medicines are required, has expanded extensively due to the overuse of antibiotics. This study aimed detect optimal ratio combination main components based on Yinhuapinggan granules (YHPG) generate concepts PRSP-induced lung injury. Three representative components: chlorogenic acid (C), amygdalin (A), and puerarin (P) were selected, these three was determined by an orthogonal experiment. Investigations conducted potential mechanisms underlying protective effect this optimized against epithelial cell damage. Meanwhile, bacteriostatic further explored through natural products combined with penicillin G (PG). The CAP (C: 16 µg/mL, A: 24 P: µg/mL) screened experimental design reduced damage in a model human cells infected PRSP, PG had synergistic effect. At cellular level, attenuated injury modulating TLRs/MyD88 inflammatory pathway. bacterial modulated virulence drug resistance resulting enhanced inhibition PG. Taken together, our results suggest that can modulate or synergize pathway attenuate injury, be used as treating PRSP infection.

Language: Английский

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Unlocking the nutritional profile of apricot (Prunus armeniaca L) kernel as a valuable by-product for future exploration

Future Foods, Journal Year: 2025, Volume and Issue: unknown, P. 100632 - 100632

Published: April 1, 2025

Language: Английский

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Laetrile and Methotrexate: A Dual-Drug Approach to Inhibiting Cervical Cancer Cell Proliferation

Journal of cancer research updates, Journal Year: 2025, Volume and Issue: 14, P. 52 - 62

Published: May 2, 2025

Objective: This study was done to evaluate the efficacy of laetrile methotrexate combination in inhibiting cervical cancer proliferation and identify synergistic effects between them Method: During three incubation periods, 24, 48, 72 hours, antiproliferative impact assessed by employing Hela cell line, a human line. The concentration range tested reagent varied from 0.1 1000 µg/ml for each methotrexate. At same time, mixture 0.05 500 both index value used whether there combination. dose reduction employed ascertain extent constituent mix, which resulted notable cytotoxic impact. Result: results revealed that successfully inhibited cells manner depended on duration treatment. exhibited significant all concentrations except µg/ml. Furthermore, outcomes showed minimized required Conclusion: Concerning findings their defined pharmacokinetic safety characteristics drugs. laetrile-methotrexate offers an attractive safer option treatment cancer.

Language: Английский

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Amygdalin as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14270 - 14270

Published: Sept. 19, 2023

Cancer rates are increasing, and cancer is one of the main causes death worldwide. Amygdalin, also known as vitamin B17 (and laetrile, a synthetic compound), cyanogenic glycoside compound that mainly found in kernels pulps fruits. This has been proposed for decades promising naturally occurring substance which may provide anticancer effects. comprehensive review critically summarizes scrutinizes available studies exploring effect amygdalin, highlighting its potential molecular mechanisms well need nontoxic formulation this substance. In-depth research was performed using most accurate scientific databases, e.g., PubMed, Cochrane, Embase, Medline, Scopus, Web Science, applying effective, characteristic, relevant keywords. There several pieces evidence to support idea amygdalin can exert effects against lung, breast, prostate, colorectal, cervical, gastrointestinal cancers. Amygdalin reported induce apoptosis cells, inhibiting cells’ proliferation slowing down tumor metastatic spread. However, only few have vivo animal models, while clinical remain even more scarce. The current cannot recommendation use nutritional supplements with due cyano-moiety exerts adverse side Preliminary data shown nanoparticles be alternative enhance simultaneously reducing seems agent disease development progression. there strong demand human explore prevention and/or treatment efficiency cancer. Moreover, could used lead by effectively recent developments drug discovery processes.

Language: Английский

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