Immune Cell Alterations in Psychotic Disorders: A Comprehensive Systematic Review and Meta-Analysis

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(5), P. 331 - 341

Published: Jan. 6, 2024

Background A comprehensive meta-analysis on the composition of circulating immune cells from both myeloid and lymphoid line including specialized subsets in blood cerebrospinal fluid (CSF) patients with psychotic disorders compared to healthy controls have been lacking. Methods Multiple databases (PubMed, EMBASE, Cochrane Library, Web Science, ClinicalTrials.gov PsycINFO) were searched for eligible studies up until October 18, 2022. All investigating CSF (ICD-10: F20 F22-29) included. Results total 86 included meta-analysis. In blood, following categories elevated: leukocyte count (31 studies, SMD=0.35; 95%-CI: 0.24-0.46), granulocyte (4 SMD=0.57; 0.12-1.01), neutrophile (21 SMD=0.32; 0.11-0.54), monocyte (23 SMD=0.40; 0.23-0.56) B lymphocyte (10 SMD=0.26; 0.04-0.48). Additionally, neutrophile/lymphocyte ratio 0.19-0.60), monocyte/lymphocyte (9 SMD=0.31; 0.04-0.57), platelet/lymphocyte SMD=0.23; 0.03-0.43) elevated. The cell showed similar tendency but was not significantly elevated (3 SMD = 0.14; -0.04 0.32). Conclusion results indicate a broad activation system being However, analyses lacking most many hampered by insufficient adjustment confounding factors as BMI smoking.

Language: Английский

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Immune dysregulation is associated with symptom dimensions and cognitive deficits in schizophrenia: accessible evidence from complete blood count

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 12, 2024

Abstract Background Schizophrenia (SCZ) is a psychotic disorder with an unknown pathogenesis accompanied by varying degrees of cognitive deficits. Recent studies have shown that immune dysregulation plays important role in developing symptoms and deficits SCZ. This study aimed to determine the complete blood count (CBC), including white cells, neutrophils, monocytes, lymphocytes, platelets, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), monocyte-lymphocyte (MLR), patients SCZ explore their correlations symptom dimensions function. Methods Seventy-four 57 age- sex-matched healthy controls available demographic clinical information were recruited for this study. Blood samples collected, function evaluated using Positive Negative Syndrome Scale (PANSS) MATRICS Consensus Cognitive Battery (MCCB) separately. Results Our results demonstrate showed higher monocyte counts, PLR, MLR, worse performance total MCCB than controls. Neutrophil lymphocyte counts NLR positively related severity negatively depressive symptoms. White cell (WBC) count, MLR correlated Conclusion In summary, suggests associated immunity. Moreover, we found WBC could be used as marker neutrophils are more closely former monocytes latter. We hope clinicians will pay attention dysregulated immunity future.

Language: Английский

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Bidirectional two-sample Mendelian randomization study of differential white blood cell counts and schizophrenia

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 118, P. 22 - 30

Published: Feb. 13, 2024

Language: Английский

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The causal relationship between immune cell traits and schizophrenia: a Mendelian randomization analysis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 27, 2024

Introduction The complex and unresolved pathogenesis of schizophrenia has posed significant challenges to its diagnosis treatment. While recent research established a clear association between immune function schizophrenia, the causal relationship two remains elusive. Methods We employed bidirectional two-sample Mendelian randomization approach investigate 731 cell traits by utilizing public GWAS data. further validated six types white measures. Results found overall effects on were significantly higher than reverse ones (0.011 ± 0.049 vs 0.001 0.016, p < 0.001), implying that disease may lead an increase in cells itself. also identified four risk schizophrenia: CD11c+ monocyte %monocyte (odds ratio (OR): 1.06, 95% confidence interval (CI): 1.03~1.09, FDR = 0.027), CD62L- (OR:1.06, CI: CD25 IgD+ CD38- naive B (OR:1.03, CI:1.01~1.06, 0.042), CD86 (OR 1.04, 0.042). However, we did not detect any traits. Using blood data, increases lymphocyte counts 95%CI: 1.01-1.04, 0.007), total (OR:1.02, 0.021) 1.00-1.03, 0.034). nominally associated with (OR:1.08,95%CI:1.01-1.16, P=0.019). Discussion Our study system is complex, enhancing our understanding role regulation development this disorder. These findings offer new insights for exploring diagnostic therapeutic options schizophrenia.

Language: Английский

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The neutrophil-lymphocyte ratio in first-episode medication-naïve patients with schizophrenia: A 12-week longitudinal follow-up study

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 131, P. 110959 - 110959

Published: Feb. 2, 2024

Language: Английский

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Correlation Between Monocyte Count, Monocyte–Lymphocyte Ratio, and Other Inflammatory Cells With Sleep and Psychiatric Symptoms in First-Episode Schizophrenia Patients

Neuropsychiatric Disease and Treatment, Journal Year: 2025, Volume and Issue: Volume 21, P. 373 - 381

Published: Feb. 1, 2025

More and more evidence shows that infection immune abnormality are closely related to the increased severity of schizophrenia symptoms. This study aimed explore correlation between inflammatory cell counts, sleep quality, psychiatric symptoms in first-episode patients. A total 103 patients (patient group) admitted Anhui Provincial Mental Health Center from November 2021 August 2022 were included study, while 57 healthy individuals (control who met criteria recruited as subjects. The Positive Negative Symptom Scale (PANSS) Pittsburgh Sleep Quality Index (PSQI) used evaluate mental status Blood analysis results determine peripheral blood white cells (WBC) lymphocytes two groups. Count neutrophils, monocytes, platelets (PLT) neutrophil lymphocyte ratio (NLR), monocyte (MLR), platelet (PLR) calculated. Differential, correlation, regression performed on survey data using SPSS 26.0. Results showed WBC, NLR, MLR higher case vs control group (p<0.05). Correlation found monocytes negatively correlated with time (rs=-0.205, p=0.037) arousal factor (rs=-0.204, p=0.039). Linear positively affected score (B=7.196, t=2.781, p=0.006) (B=-0.851, t=-2.157, p=0.033). ROC revealed high sensitivity specificity for SCZ symptom prediction. concluded elevated levels significantly associated symptoms, particularly affecting factors, demonstrated predictive validity

Language: Английский

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Differences in Blood Leukocyte Subpopulations in Schizophrenia

JAMA Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

This study aims to provide robust evidence support or challenge the immune hypothesis of schizophrenia. To conduct a meta-analysis reports on blood leukocyte subpopulations in schizophrenia vs healthy controls, examining disease- and treatment-related differences as well potential confounders. Systematic database search for English non-English peer-reviewed articles PubMed, Web Science, Scopus, Cochrane Library databases, with last January 2024. Cross-sectional, case-control, longitudinal studies comparing numbers patients controls. After duplicates were removed, 3691 identified screening. Data extraction quality assessment conducted following PRISMA MOOSE guidelines. independently extracted by 2 authors pooled using random-effects models. The planned primary outcomes subpopulation counts between individuals controls increase our understanding system dysfunction Sixty-four relevant (60 cross-sectional/case-control 4 studies) data from 26 349 16 379 Neutrophils (g = 0.69; 95% CI, 0.49 0.89; Bonferroni-adjusted P < .001; n 40 951 [47 between-group comparisons]) monocytes 0.49; 0.24 0.75; 513 [44 higher compared control participants. Differences greater first-episode chronic who not treated antipsychotic medication. There no significant eosinophils 0.02; -0.16 0.20; > .99; 3277 [18 comparisons]), basophils 0.14; -0.06 0.34; .85; 2614 [13 lymphocytes -0.08; -0.21 0.06; 41 693 [59 comparisons]). decreased longitudinally -0.30; -0.45 -0.15; 896 [4 within-group increased 0.61; 0.52 0.71; 876 [3 after successful treatment acute psychosis. Our findings neutrophils schizophrenia, particularly highlighting role innate activation. As these effects more pronounced early disease stages also reflected clinical improvement, they may pave way innovative strategies based immunological inflammatory pathways help revolutionize landscape

Language: Английский

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Toxoplasma gondii, endothelial cells and schizophrenia: is it just a barrier matter?

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 10, 2025

Toxoplasma gondii is an obligatory intracellular parasite responsible for causing toxoplasmosis. It estimated that approximately one-third of the world's population has positive serology Acute T. infection often results in subtle symptoms because its nonspecific nature. Owing to immune pressure, parasites tend encyst and persist different tissues organs, such as brain, chronicling infection. While most chronically infected individuals do not develop significant symptoms, can affect central nervous system (CNS), leading range from dizziness behavioral changes. To reach CNS, must overcome blood-brain barrier, which composed primarily endothelial cells. these cells are typically efficient at separating blood elements infection, they only permit parasitic colonization CNS but also contribute inflammatory profile may exacerbate previously established conditions both local systemic levels. An increasing body research demonstrated a potential link between by cellular or humoral response with worsening psychiatric conditions, schizophrenia. Therefore, continually advancing aimed understanding mitigating relationship schizophrenia imperative.

Language: Английский

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Weight-adjusted waist index and its relationship with systemic inflammatory Index and metabolic indices in overweight and obese individuals: A cross-sectional study

Science Progress, Journal Year: 2025, Volume and Issue: 108(2)

Published: April 1, 2025

Background Obesity- characterized by excessive adiposity- is associated with various comorbidities, including metabolic, cardiovascular, and liver diseases. Chronic low-grade inflammation a key factor in complications obesity. This study aimed to investigate the associations between systemic inflammatory indices (SIIs) weight-adjusted waist index (WWI), alongside metabolic function biomarkers overweight obese individuals. Method cross-sectional included 350 or participants (body mass (BMI) ≥ 25 kg/m 2 ) from both genders. Weight, height, waist, hip, neck circumferences were measured BMI, WWI, ratios of height (WHtR) hip (WHR) estimated. Fasting blood samples taken assess SII as well parameters. Results In this study, males had significantly higher weight WC compared females, whereas mean level WWI (p < 0001) WHtR = 0.01) women greater than men. A significant correlation was observed (r 0.113, p 0.039), other HbA1c levels −0.117, 0.033) monocyte-to-lymphocyte ratio (MLR), fasting sugar (FBS) neutrophil-to-lymphocyte NLR 0.110, 0.041). quartiles showed differences aspartate aminotransferase AST 0.001), variations MLR also −0.112, 0.043). Conclusion Our results reveal strong correlations markers, SII, MLR, PLR, important obesity measures, parameters individuals

Language: Английский

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Complete blood count-based inflammation indexes and symptom severity in people with schizophrenia spectrum disorders: An analysis based on structural equation modelling

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 168, P. 107134 - 107134

Published: July 14, 2024

Schizophrenia spectrum disorders (SSDs) are associated with immune-inflammatory activation. Recently, complete blood count (CBC)-based inflammation indexes such as the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte (PLR) have emerged reproducible cost-effective markers in mental disorders. In this study, we aimed at investigating relationship of NLR, MLR, PLR symptom severity people SSDs, testing interactions relevant clinical variables.

Language: Английский

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