Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions DOI Open Access

Keshav Juneja,

Hamsa Priya Bhuchakra,

S. SADHUKHAN

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Depression, affecting millions of people worldwide, is a leading cause disability globally. It affects not only daily functioning but also interpersonal relationships and overall health by increasing the risks chronic physical mental illnesses. Creatine, traditionally recognized for boosting performance through its role in producing adenosine triphosphate, has recently shown potential as an adjunctive therapy treating depression. Creatine's ability to enhance brain energy metabolisms provide neuroprotection suggests that it can alleviate mood disorders improving mitochondrial function, cellular resilience, modulating neurotransmitter systems regulate mood. This narrative review aims critically evaluate research on creatine supplementation depression, focusing efficacy, mechanism action, risks, benefits treatment disorders. analyzes preclinical clinical studies understand creatine's or alternative major depressive disorder bipolar depression underscores any gaps current research. Both animal models human trials indicate efficacy Creatine reduces symptoms, particularly when combined with selective serotonin reuptake inhibitors, may improve metabolism neuroplasticity. generally well tolerated, though caution warranted due side effects such manic episodes renal function impairment patients kidney dysfunction. Overall, presents promising addition treatments, further needed establish optimal dosing, long-term safety across diverse patient populations.

Language: Английский

Mitochondria in depression: The dysfunction of mitochondrial energy metabolism and quality control systems DOI Creative Commons

Mengruo Jiang,

Liyuan Wang,

Hui Sheng

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)

Published: Feb. 1, 2024

Depression is the most disabling neuropsychiatric disorder, causing difficulties in daily life activities and social interactions. The exact mechanisms of depression remain largely unclear. However, some studies have shown that mitochondrial dysfunction would play a crucial role occurrence development depression.

Language: Английский

Citations

20
Glucose metabolism impairment in major depressive disorder DOI Creative Commons

Fanhao Meng,

Jing Wang, Long Wang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111191 - 111191

Published: Jan. 7, 2025

Major depressive disorder (MDD) is a common mental with chronic tendencies that seriously affect regular work, life, and study. However, its exact pathogenesis remains unclear. Patients MDD experience systemic localized impairments in glucose metabolism throughout the disease course, disrupting various processes such as uptake, glycoprotein transport, glycolysis, tricarboxylic acid cycle (TCA), oxidative phosphorylation (OXPHOS). These may result from mechanisms including insulin resistance, hyperglycemia-induced damage, stress, astrocyte abnormalities, mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, functional structural damage reward networks. mechanical changes contribute of severely interfere prognosis. Herein, we summarized impairment pathophysiological patients MDD. In addition, briefly discussed potential pharmacological interventions for alleviate MDD, glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, pioglitazone, encourage development new therapeutics.

Language: Английский

Citations

1
Targeting mitophagy for depression amelioration: a novel therapeutic strategy DOI Creative Commons

Wangjun Xu,

Wei-Ping Gao,

Yukun Guo

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Oct. 6, 2023

Major depressive disorder is a global psychiatric condition characterized by persistent low mood and anhedonia, which seriously jeopardizes the physical mental well-being of affected individuals. While various hypotheses have been proposed to explicate etiology depression, precise pathogenesis effective treatment this remain elusive. Mitochondria, as primary organelles responsible for cellular energy production, possess ability meet essential demands brain. Research indicated that accumulation damaged mitochondria associated with onset depression. Mitophagy, type autophagy, specifically targets removes excess or mitochondria. Emerging evidence demonstrated mitophagy dysfunction was involved in progression several pharmacological interventions stimulating exerted excellent antidepressant actions. We provided an overview updated advancements on regulatory mechanism abnormality depressed patients animals, well cell models Meanwhile, therapeutic strategies restore depression alleviation were also discussed review.

Language: Английский

Citations

13
Pharmacological mechanism of natural antidepressants: The role of mitochondrial quality control DOI
Shimeng Lv, Guangheng Zhang,

Yitong Lu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155669 - 155669

Published: April 28, 2024

Language: Английский

Citations

3
Ganoderic acid A ameliorates depressive-like behaviors in CSDS mice: Insights from proteomic profiling and molecular mechanisms DOI

XU Jin-jie,

Wei-jing Kan,

Tianyi Wang

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 358, P. 270 - 282

Published: May 7, 2024

Language: Английский

Citations

3
Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine DOI
Eun‐Sook Park, Chan Young Shin,

Se Jin Jeon

et al.

Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: 32(6), P. 659 - 684

Published: Oct. 21, 2024

Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and rise of long COVID. Viruses such Herpes Simplex Virus (HSV), Epstein-Barr (EBV), Cytomegalovirus (CMV), Human Immunodeficiency (HIV) linked to depression through complex neurobiological mechanisms. These include immune system dysregulation, chronic inflammation, neurotransmitter imbalances that affect brain function mood regulation. activation leads release pro-inflammatory cytokines, resulting in neuroinflammation associated symptoms. Furthermore, specific viruses can disrupt systems, including serotonin, dopamine, glutamate, all which essential stabilization. The unique interactions different with these systems underscore need virus-specific therapeutic approaches. Current broad-spectrum treatments often overlook precise pathways involved post-viral depression, reducing their efficacy. This review emphasizes understand create tailored interventions directly address effects induced by each type virus. may immunomodulatory target persistent antiviral therapies reduce viral load, or neuroprotective strategies restore balance. Precision medicine offers promising avenues effective management virus-induced providing patient-specific approaches biological mechanisms involved. By focusing on development targeted treatments, this aims pave way a new era psychiatric care fully addresses root causes infections.

Language: Английский

Citations

3
Association between depressive symptoms and premature death: An exploratory mediation analysis via mitochondrial function DOI Creative Commons
Kun Lian, Xi Zhang, Chenglong Shi

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 375, P. 373 - 379

Published: Jan. 30, 2025

Language: Английский

Citations

0
Ferroptosis, pathogenesis and therapy in AS co-depression disease DOI Creative Commons

Yulong Zhao,

Peng Ren,

Qiang Luo

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Atherosclerosis (AS)-related cardiovascular disease and depression are often comorbid, with patients facing an increased risk of depression, which worsens AS. Both diseases characterized by oxidative stress lipid metabolism disorders. Ferroptosis, a form cell death iron overload harmful peroxide accumulation, is found in various diseases, including AS depression. Consistent the deposition peroxidation (LPO) that characterize ferroptosis mechanism, disturbances also crucial pathogenic mechanisms The comorbid complex, posing challenges for clinical treatment. Chinese herbs hold significant potential owing to their multi-target pharmacological effects. Therefore, this review aims investigate overload, LPO, across types, shared pathogenesis ferroptosis, research on herbal medicine targeting treatment anti-AS co-depression. This provides comprehensive understanding co-depression from perspective ferroptosis.

Language: Английский

Citations

0
Zhizichi decoction alleviates depressive-like behaviors through modulating mitochondria-associated membrane via the IP3R3-GRP75-VDAC1 complex DOI
Ye Liu,

Zicheng Zhang,

Yimeng Zhao

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119628 - 119628

Published: March 1, 2025

Language: Английский

Citations

0
Antidepressant-like effects of the aqueous lyophilizate of the stems and leaves of Momordica foetida (Cucurbitaceae) in rats DOI Creative Commons

Bibiane Tatiana Diebo Kom,

Gwladys Temkou Ngoupaye, Francis Bray Yassi

et al.

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: 18, P. 464 - 475

Published: March 12, 2025

M. foetida (Cucurbitaceae) is a perennial climbing herb, known in traditional medicine for the treatment of certain diseases, such as malaria, headaches, skin-related problems and many others. The objective this work was to evaluate antidepressant effect aqueous lyophilisate mixture leaves stem foetida. at different doses (25 mg/kg, 50 mg/kg 75 mg/kg) evaluated Wistar rats both sexes submitted chronic restriction 14 days, using forced swimming test, open field test sucrose preference test. One hour following last behavioural animals were sacrificed their hippocampi collected biochemical assessment oxidative parameters, including malondialdehyde (MDA), reduced Glutathione (GSH), Catalase activity, superoxide dismutase (SOD) nitric oxide (NO) well monoamines levels serotonin, noradrenaline dopamine. significantly decreased immobility time increased consumption (P < 0.001), with no alteration locomotor activity. concentrations GSH, SOD, catalase while reducing MDA NO all 0.001). 25 concentration serotonin Only dose (p These results suggest that exerts antidepressant-like effects through modulation stress monoaminergic pathways.

Language: Английский

Citations

0