Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 9805 - 9822
Published: Nov. 1, 2024
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disease
characterized
by
joint
inflammation
and
bone
destruction,
leading
to
severe
complications.
Previous
research
has
suggested
that
high
humidity
conditions
may
exacerbate
RA,
however,
the
underlying
mechanisms
remain
unclear.
Furthermore,
there
a
lack
of
evidence
linking
worsening
RA
symptoms
in
animal
models.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(6), P. 7003 - 7011
Published: Feb. 1, 2024
This
study
aims
to
assess
the
anti-inflammatory
potential
of
stearic
acid
nanoparticles
quercetin
in
an
arthritic
rat
model.
article
describes
fabrication
solid
lipid
(SLNs)
using
hot
melt
encapsulation
method,
followed
by
SLNs
and
other
characterizations
such
as
FTIR,
XRD,
SEM.
Thirty
male
healthy
albino
rats
were
taken
treated
with
FCA
induce
rheumatoid
arthritis.
Quercetin
loading
was
confirmed
FTIR.
The
efficacy
quercetin-loaded
reduce
inflammation
evaluated
help
inflammatory
biomarker
levels.
Quercetin-loaded
successfully
prepared
a
method.
Their
average
size
zeta
100
nm
−25
mV,
respectively.
Rheumatoid
arthritis
significantly
(p
<
0.001)
reduced
SLN
group,
indicated
finding
out
levels
mediators
tumor
necrosis
factor
(TNF-α)
factor.
found
be
potentially
effective
treating
RA.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 26, 2024
Phosphatase
and
tensin
homolog
deleted
on
chromosome
10
(PTEN)
is
a
critical
tumor
suppressor
protein
that
regulates
various
biological
processes
such
as
cell
proliferation,
apoptosis,
inflammatory
responses
by
controlling
the
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(PI3K/AKT)
signaling
pathway.
PTEN
plays
crucial
role
in
pathogenesis
of
rheumatoid
arthritis
(RA).
Loss
may
contribute
to
survival,
pro-inflammatory
cytokine
release
fibroblast-like
synoviocytes
(FLS).
Also,
persistent
PI3K
increases
myeloid
cells'
osteoclastic
potential,
enhancing
localized
bone
destruction.
Recent
studies
have
shown
expression
synovial
lining
RA
patients
with
aggressive
FLS
minimal.
Experimental
upregulation
could
reduce
damage
caused
RA.
Nonetheless,
complete
comprehension
aberrant
drives
progression
its
interactions
other
molecules
remains
elusive.
This
review
dedicated
promoting
thorough
understanding
mechanisms
aims
furnish
pertinent
theoretical
support
for
forthcoming
endeavors
both
basic
clinical
research
within
this
domain.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 31, 2024
PANoptosis
is
a
newly
identified
inflammatory
programmed
cell
death
(PCD)
that
involves
the
interplay
of
apoptosis,
necrosis,
and
pyroptosis.
However,
its
overall
biological
effects
cannot
be
attributed
to
any
one
type
PCD
alone.
regulated
by
signaling
cascade
triggered
recognition
pathogen-associated
molecular
patterns
(PAMPs)
damage-associated
(DAMPs)
various
sensors.
This
triggers
assembly
PANoptosome,
which
integrates
key
components
from
other
pathways
via
adapters
ultimately
activates
downstream
execution
molecules,
resulting
in
with
necrotic,
apoptotic,
pyroptotic
features.
Autoimmune
diseases
are
characterized
reduced
immune
tolerance
self-antigens,
leading
abnormal
responses,
often
accompanied
systemic
chronic
inflammation.
Consequently,
PANoptosis,
as
unique
innate
immune-inflammatory
pathway,
has
significant
pathophysiological
relevance
inflammation
autoimmunity.
most
previous
research
on
focused
tumors
infectious
diseases,
leaving
activation
role
autoimmune
unclear.
review
briefly
outlines
characteristics
summarizes
several
PANoptosome
complexes,
their
mechanisms,
components.
We
also
explored
dual
potential
therapeutic
approaches
targeting
PANoptosis.
Additionally,
we
existing
evidence
for
explore
regulatory
mechanisms
involved.
IgMin Research,
Journal Year:
2025,
Volume and Issue:
3(1), P. 021 - 026
Published: Jan. 1, 2025
Rheumatoid
Arthritis
(RA)
is
a
chronic
auto-immune
disease
that
mostly
occurs
in
joint
space
with
remarkably
painful
swelling.
RA
detail
pathologies
remain
unclear,
but
several
C-C
motif
chemokines
factors
and
Interleukin
have
been
identified
as
associated
correlated
disease-associate
activities
(such
CCL2,
CCL18,
IL-6).
Among
these
factors,
increasing
evidence
indicates
CCL18
could
be
an
appropriate
drug
target,
it
highly
disease-associated
(DAS28)
(elevated
level
of
both
patient
serum
local
synovial
fluids).
High-concentration
fluids
has
reported
to
facilitate
pro-inflammation
factor
production,
finally
resulting
swelling
space.
In
vivo
studies
showed
significant
efficiency
anti-TNF-a
treatment
(CCl18
suppression).
Most
current
approved
drugs
target
TNF,
IL-6,
or
other
do
not
directly
indirectly.
From
this
perspective,
believed
new
for
therapeutic
development.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2569 - 2569
Published: Aug. 5, 2024
It
is
now
established
that
patients
with
rheumatoid
arthritis
(RA)
have
an
increased
risk
of
developing
cervical
cancer
(CC)
or
its
precursor,
intraepithelial
neoplasia
(CIN).
However,
the
underlying
mechanisms
this
association
not
been
elucidated.
RA
characterized
by
unresolved
chronic
inflammation.
suggested
human
papillomavirus
(HPV)
infection
in
exacerbates
inflammation,
increasing
CC.
The
tumor
microenvironment
CC
also
marked
which
aggravates
manifestations
both
conditions.
Gut
and
vaginal
dysbiosis
are
considered
potential
contribute
to
inflammation
aggravation
manifestations.
Numerous
clinical
pre-clinical
studies
demonstrated
beneficial
effects
various
nutritional
approaches
attenuate
including
polyunsaturated
fatty
acids
their
derivatives,
specialized
pro-resolving
mediators
(SPMs),
probiotics,
prebiotics,
certain
diets.
We
believe
successful
resolution
correction
dysbiosis,
combination
current
anti-RA
anti-CC
therapies,
a
promising
therapeutic
approach
for
This
could
reduce
development
HPV-infected
patients.
Medicina,
Journal Year:
2023,
Volume and Issue:
59(10), P. 1853 - 1853
Published: Oct. 18, 2023
Rheumatoid
arthritis
refers
to
joint
diseases
of
unclear
etiology
whose
final
stages
can
lead
unbearable
pain
and
complete
immobility
the
affected
joints.
As
one
most
widely
known
joints,
it
serves
as
a
study
target
for
large
number
research
groups
pharmaceutical
companies.
Modern
treatment
with
anti-inflammatory
drugs,
including
janus
kinase
(JAK)
inhibitors,
monoclonal
antibodies,
botanicals
(polyphenols,
glycosides,
alkaloids,
etc.)
has
achieved
some
success
hope
improving
course
disease.
However,
existing
drugs
against
RA
have
side
effects
which
push
researchers
elaborate
on
more
selective
effective
drug
candidates.
The
avant-garde
research,
aims
develop
rheumatoid
using
antisense
oligonucleotides
along
nonsteroidal
corticosteroids
inflammation,
increases
chances
expands
arsenal
drugs.
primary
goal
in
this
disease
is
find
therapies
that
allow
patients
move
their
joints
without
pain.
main
purpose
review
show
victories
challenges
tortuous
but
promising
path
help
experience
joy
freely
moving
Current Drug Targets,
Journal Year:
2023,
Volume and Issue:
24(17), P. 1298 - 1316
Published: Dec. 1, 2023
Abstract:
Rheumatoid
arthritis
is
an
untreatable
autoimmune
disorder.
The
disease
accompanied
by
joint
impairment
and
anomalies,
which
negatively
affect
the
patient’s
quality
of
life
contribute
to
a
decline
in
manpower.
To
diagnose
treat
rheumatoid
arthritis,
it
crucial
understand
abnormal
signaling
pathways
that
disease.
This
understanding
will
help
develop
new
arthritis-related
intervention
targets.
Over
last
few
decades,
researchers
have
given
more
attention
arthritis.
current
review
seeks
provide
detailed
summary
highlighting
basic
description
disease,
past
occurrences,
study
epidemiology,
risk
elements,
process
progression,
as
well
key
scientific
development
condition
multiple
enumerating
most
advancements
discovering
inhibitors.
emphasizes
anti-rheumatoid
effects
these
inhibitors
[for
Wnt/β-catenin,
Phosphoinositide
3-Kinases
(PI3K/AKT),
Spleen
Tyrosine
Kinase
(SYK),
Granulocyte-Macrophage
Colony-Stimulating
Factor
(GM-CSF)
pathways],
illustrating
their
mechanism
action
through
literature
search,
therapies,
novel
drugs
under
pre-clinical
clinical
trials.
Advances in Rheumatology,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Jan. 18, 2024
Abstract
Background
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
that
may
cause
joint
deformities
and
seriously
affect
the
normal
life
of
patients.
In
order
to
enable
patients
receive
timely
attention
treatment,
this
study
developed
new
diagnostic
markers
by
exploring
expression
molecular
mechanism
long
non-coding
RNA
NORAD
(NORAD)
in
RA.
Methods
Participants
including
77
RA
52
healthy
persons
were
enrolled,
corresponding
clinical
data
serum
samples
obtained.
The
miR-204-5p
detected
real-time
fluorescence
quantitative
polymerase
chain
reaction
(RT-qPCR).
content
inflammatory
cytokines
(IL-6,
TNF-α)
determined
through
enzyme-linked
immunosorbent
assay
(ELISA).
Luciferase
activity
reporter
demonstrated
association
between
miR-204-5p.
addition,
receiver
operating
characteristic
(ROC)
curve
was
used
evaluate
efficacy
NORAD,
Pearson’s
correlation
analysis
applied
for
analysis.
Results
enriched
with
high
value.
Simultaneously,
IL-6
TNF-α
levels
also
upregulated
(
P
<
0.001).
C-reactive
protein
(CRP),
rheumatoid
factor
(RF),
erythrocyte
sedimentation
rate
(ESR)
anti-cyclic
citrullinated
peptide
antibody
(Anti-CCP)
generally
elevated
positively
correlated
indicators
factors
0.0001).
Mechanistically,
progression
targeting
negatively
regulating
Conclusions
There
processes
RA,
has
potential
predict
diagnose
occurrence
