The role of leptin in regulation of the soluble amyloid precursor protein α (sAPPα) levels in lung cancer cell media DOI Creative Commons

Ben Haddad,

Jeneen Khalil,

Hind Al Khashali

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 28, 2024

Previously, we found that the levels of soluble amyloid precursor protein α (sAPPα) are regulated, in part, by acetylcholinesterase (AChE) human A549 (p53 wild-type) and H1299 (p53-null) NSCLC cell lines. In this study, regulation sAPPα media leptin, a widely recognized obesity-associated adipokine has recently been shown to play possible role cancer signaling. Increased sAPPα, were accompanied lower Aβ40/42 cells, detected upon incubation with leptin. Conversely, knockdown leptin or its receptor led reduced increased suggesting likely shifts APP processing toward non-amyloidogenic pathway. treatment acetylcholine blocked activities AChE p53. Treatment resulted activation PKC, ERK1/2, PI3K, effects reversed kinase inhibitors and/or addition media. Cell viability cells decreased co-treatment targeting PI3K. This study is significant as it provides evidence for carcinogenic via upregulation media, highlights importance potential therapeutic strategy treatment.

Language: Английский

Role of Leptin and Adiponectin in Carcinogenesis DOI Open Access
Agnes Bocian, Anna Malczewska, Beata Kos‐Kudła

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(17), P. 4250 - 4250

Published: Aug. 24, 2023

Hormones produced by adipocytes, leptin and adiponectin, are associated with the process of carcinogenesis. Both these adipokines have well-proven oncologic potential can affect many aspects tumorigenesis, from initiation primary tumor growth to metastatic progression. Involvement in formation cancer includes interactions microenvironment its components, such as tumor-associated macrophages, cancer-associated fibroblasts, extracellular matrix metalloproteinases. Furthermore, participate epithelial–mesenchymal transition connect angiogenesis, which is critical for invasiveness cell migration. In addition, an enormous amount evidence has demonstrated that altered concentrations adipocyte-derived hormones expression their receptors tumors poor prognosis various types cancer. Therefore, adiponectin dysfunction play a prominent role impact invasion metastasis different ways. This review clearly comprehensively summarizes recent findings presents initiation, promotion progression, focusing on associations components well roles angiogenesis.

Language: Английский

Citations

37
Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25–57% elevation in risk DOI Creative Commons
Zoltán Ungvári, Mónika Fekete, Péter Varga

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract The incidence of colorectal cancer (CRC) has been steadily rising, and obesity identified as a significant risk factor. Numerous studies suggest strong correlation between excess body weight increased CRC, but comprehensive quantification through pooled analysis remains limited. This study aims to systematically review meta-analyze the existing literature evaluate association CRC risk, considering variations across sex designs. A systematic search was conducted in PubMed, Cochrane Central Register Controlled Trials (CENTRAL), Web Science identify randomized controlled trials human clinical from 1992 2024. Statistical performed using https://metaanalysisonline.com web application random effects model estimate hazard rates (HR). Forest plots, funnel Z-score plots were utilized visualize results. We 52 14 case–control studies, encompassing total 83,251,050 236,877 subjects, respectively. indicated that significantly prevalence (HR = 1.36, 95% CI 1.24–1.48, p < 0.01). effect consistent sexes, with HRs 1.57 (95% 1.38–1.78, 0.01) for males 1.25 1.14–1.38, females. Case–control specifically showed an effect, marginal significance only 1.27, 0.98–1.65, 0.07). plot need additional group. heterogeneity observed all four settings. meta-analysis provides robust evidence is factor cancer, overall rate indicating 36% risk. pronounced both showing slightly higher compared Although weaker association, trend supports link CRC. These results underscore importance public health interventions aimed at reducing potentially lower cancer.

Language: Английский

Citations

12
Circulating Cell-Free DNA Integrity for Breast and Prostate Cancer: What Is the Landscape for Clinical Management of the Most Common Cancers in Women and Men? DOI Open Access
Navid Sobhani, Domenico Tierno, Nicola Pavan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 900 - 900

Published: Jan. 22, 2025

Breast cancer (BC) and prostate (PCa) are major health problems for women men worldwide. Although therapeutic approaches have increased, the complexity associated with their heterogeneity progression requires better ways to monitor them over time. Cell-free DNA integrity (cfDI) represents a viable alternative needle biopsy has potential be representative of at all stages. In addition advantages liquid in terms cost reduced invasiveness, cfDI can used detect repetitive elements (e.g., ALU LINE1), which could circumvent problem mutational BC PCa. this review, we summarise latest findings on studies The results show that improve early detection, metastasis, recurrence BC, while limited prevent its clinical value PCa from being fully defined. However, it is expected further near future will help introduce use as another biomarker monitoring patients.

Language: Английский

Citations

2
Omega-3 fatty acids: molecular weapons against chemoresistance in breast cancer DOI Creative Commons

Vittoria Marchio,

Giuseppina Augimeri,

Catia Morelli

et al.

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 25, 2025

Abstract Breast cancer is the most commonly diagnosed type of and leading cause cancer-related death in women worldwide. Highly targeted therapies have been developed for different subtypes breast cancer, including hormone receptor (HR)-positive human epidermal growth factor 2 (HER2)-positive cancer. However, triple-negative (TNBC) metastatic disease are primarily treated with chemotherapy, which improves disease-free overall survival, but does not offer a curative solution these aggressive forms Moreover, development chemoresistance major therapeutic failure this neoplasia, to relapse patient death. In addition, chemotherapy’s adverse side effects may substantially worsen health-related quality life. Therefore, improve outcome patients who undergoing several options under investigation, combination chemotherapeutic drugs natural compounds. Omega-3 (ω-3) polyunsaturated fatty acids (PUFAs), docosahexaenoic eicosapentaenoic acids, drawn attention their antitumoral properties preventive activities against chemotherapy-induced toxicities A literature review was conducted on PubMed using keywords related omega-3, chemoresistance, chemotherapy. This aims provide an overview molecular mechanisms driving focusing role ω-3 PUFAs recognized cellular paths presenting current findings combined management.

Language: Английский

Citations

1
Autoimmune mechanisms and inflammation in obesity-associated type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver disease DOI

Yuanyuan Sun,

Xueting Shan,

Mingyang Li

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

Language: Английский

Citations

1
Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases DOI Creative Commons

Nan Zhang,

Hai‐Han Liao,

Zheng Lin

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 689 - 689

Published: June 13, 2024

Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play pivotal roles in various physiological processes. Disruptions the balance between ROS levels body’s antioxidant defenses can lead to development numerous diseases. Glutathione peroxidase 3 (GPX3), a key component system, is an oxidoreductase enzyme. GPX3 mitigates oxidative damage by catalyzing conversion hydrogen peroxide into water. Beyond its function, vital regulating metabolism, modulating cell growth, inducing apoptosis facilitating signal transduction. It also serves as significant tumor suppressor cancers. Recent studies have revealed aberrant expression several non-neoplastic diseases, associating it with multiple pathological This review synthesizes current understanding regulation, highlighting extensive noncancerous Additionally, this paper evaluates potential diagnostic biomarker explores emerging therapeutic strategies targeting enzyme, offering avenues for future clinical treatment conditions.

Language: Английский

Citations

8
Exploring the Interplay of Genetics and Nutrition in the Rising Epidemic of Obesity and Metabolic Diseases DOI Open Access
Sylwia Górczyńska-Kosiorz,

Matylda Kosiorz,

Sylwia Dzięgielewska-Gęsiak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3562 - 3562

Published: Oct. 21, 2024

Obesity has become a significant global health issue. This multifaceted condition is influenced by genetic, environmental, and lifestyle factors, significantly nutrition.

Language: Английский

Citations

6
Obesity and early-onset colorectal cancer risk: emerging clinical evidence and biological mechanisms DOI Creative Commons
Peng Xu, Tao Zuo,

Hua Yang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 2, 2024

Early-onset colorectal cancer (EOCRC) is defined as diagnosed at younger than 50 years of age and indicates a health burden globally. Patients with EOCRC have distinct risk factors, clinical characteristics, molecular pathogenesis compared older patients CRC. Further investigations identified different roles obesity between late-onset (LOCRC). Most studies focused on the characteristics in EOCRC, therefore, mechanism involved association remains inconclusive. This review further states that affects carcinogenesis well its development progression, which may lead to obesity-related metabolic syndrome, intestinal dysbacteriosis, inflammation.

Language: Английский

Citations

5
Rethinking the Role of Orexin in the Regulation of REM Sleep and Appetite DOI Open Access
Maria P. Mogavero, Justyna Godos, Giuseppe Grosso

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3679 - 3679

Published: Aug. 22, 2023

Orexin plays a significant role in the modulation of REM sleep, as well regulation appetite and feeding. This review explores, first, current evidence on orexin sleep wakefulness highlights that should be considered essentially neurotransmitter inhibiting and, to much lesser extent, wake promoting agent. Subsequently, relationship between orexin, is examined detail, shedding light their interconnected nature both physiological conditions diseases (such narcolepsy, sleep-related eating disorder, idiopathic hypersomnia, night syndrome). Understanding intricate vital for unraveling complex mechanisms underlying sleep-wake patterns metabolic control. Further research this field encouraged order pave way novel therapeutic approaches disorders associated with dysregulation.

Language: Английский

Citations

13
The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging DOI Creative Commons

Zheng Ding,

Yuqiu Wei,

Jing Peng

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2711 - 2711

Published: Oct. 5, 2023

Nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic-dysfunction-associated (MASLD), is liver-metabolism-associated steatohepatitis caused by nonalcoholic factors. NAFLD/MASLD currently the most prevalent in world, affecting one-fourth of global population, and its prevalence increases with age. Current treatments are limited; one important reason hindering drug development insufficient understanding onset pathogenesis NAFLD/MASLD. C-reactive protein (CRP), a marker inflammation, has been linked to NAFLD aging recent studies. As conserved acute-phase protein, CRP widely characterized for host defense functions, but link between remains unclear. Herein, we discuss available evidence involvement MASLD identify areas where further research needed. We hope this review can provide new insights into aging-associated biomarkers suggest that modulation signaling potential therapeutic target.

Language: Английский

Citations

10