Investigating the anti-obesity potential of Nelumbo nucifera leaf bioactive compounds through machine learning and computational biology methods DOI Creative Commons
Hongyun Huang,

Chengyu Liu,

Can Cao

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Obesity, a growing global health concern, is linked to severe ailments such as cardiovascular diseases, type 2 diabetes, cancer, and neuropsychiatric disorders. Conventional pharmacological treatments often have significant side effects, highlighting the need for safer alternatives. Traditional Chinese Medicine (TCM) offers potential solutions, with plant extracts like those from

Language: Английский

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer DOI
Ming Gu, Yang Liu, Wenhui Zheng

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 43 - 57

Published: Aug. 29, 2024

Language: Английский

Citations

12
Green synthesis, in silico modeling, and biological evaluation of N-substituted (Z)-5-arylidene imidazolidine/thiazolidine-2,4-dione/4-thione derivatives catalyzed by Bu SO3H core–shell nanostructures DOI Creative Commons
Malihe Akhavan, Zohreh Esam,

Atefeh Mirshafa

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(32), P. 22916 - 22938

Published: Jan. 1, 2024

The newly designed magnetic nanocatalyst Fe 3 O 4 @CPTMS@guanidine–BuSO H in a one-pot multicomponent reaction is reported to obtain N -substituted ( Z )-5-arylidene imidazolidine/thiazolidine-2,4-dione/4-thione as highly selective antiproliferation agent.

Language: Английский

Citations

4
Thiazolidinedione derivatives in cancer therapy: exploring novel mechanisms, therapeutic potentials, and future horizons in oncology DOI
Gaurav Ranjan, Shashi Ranjan, Priyashree Sunita

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Language: Английский

Citations

4
Therapeutic Potential and Challenges of Pioglitazone in Cancer Treatment DOI Creative Commons
Maria Vasileiou, Sotirios Charalampos Diamantoudis, Christina Tsianava

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 1925 - 1925

Published: Feb. 13, 2025

Pioglitazone (ACTOS) is a thiazolidinedione for peroxisome proliferator-activated receptor γ (PPAR-γ) that has been well established the second or third line treatment of type 2 diabetes mellitus. Beyond effects on glucose metabolism, pioglitazone displays positive lipid blood pressure, endothelial function, bone density, and apoptosis cancer cells. In fact, according to in vitro experiments preclinical studies, PPAR-γ ligand currently considered potential target both chemoprevention therapy. ligands are known inhibit cell proliferation metastasis through terminal differentiation underexpression inflammatory mediators. Despite its anticancer properties, was withdrawn by national medicine agencies France Germany, due reports increased incidence bladder cancer. These were associated with European populations undergoing higher doses longer durations treatment. this review, we discuss pharmacokinetics, therapeutic potential, limitations regarding clinical use pioglitazone, focus

Language: Английский

Citations

0
Decoding proteomic cross-talk between hypobaric and normobaric hypoxia: Integrative analysis of oxidative stress, cytoskeleton remodeling, and inflammatory pathways DOI

Poornima Sharma,

Swaraj Mohanty, Yasmin Ahmad

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123611 - 123611

Published: April 1, 2025

Language: Английский

Citations

0
Understanding Ibrilatazar’s mechanism of action: Addressing concerns about autophagy in cancer Therapy DOI
Joaquim Bosch‐Barrera, Héctor Perez‐Montoyo, Carles Domènech

et al.

Lung Cancer, Journal Year: 2025, Volume and Issue: 203, P. 108538 - 108538

Published: April 19, 2025

Language: Английский

Citations

0
Exploring transcriptomic mechanisms underlying pulmonary adaptation to diverse environments in Indian rams DOI

Ritika Gera,

Reena Arora, Pooja Chhabra

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Nov. 1, 2024

Language: Английский

Citations

1
Identification of significant hub genes and pathways associated with metastatic breast cancer and tolerogenic dendritic cell via bioinformatics analysis DOI

Kirstie Wong Chee Ching,

Noor Fatmawati Mokhtar, Gee Jun Tye

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 184, P. 109396 - 109396

Published: Nov. 16, 2024

Language: Английский

Citations

1
Detection of serum SNHG22 and its correlation with prognosis of non-small cell lung cancer DOI Creative Commons
Quan Cheng, Guoping Chen,

Xiaojiao Wu

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 20, 2024

Language: Английский

Citations

0
Investigating the anti-obesity potential of Nelumbo nucifera leaf bioactive compounds through machine learning and computational biology methods DOI Creative Commons
Hongyun Huang,

Chengyu Liu,

Can Cao

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Obesity, a growing global health concern, is linked to severe ailments such as cardiovascular diseases, type 2 diabetes, cancer, and neuropsychiatric disorders. Conventional pharmacological treatments often have significant side effects, highlighting the need for safer alternatives. Traditional Chinese Medicine (TCM) offers potential solutions, with plant extracts like those from

Language: Английский

Citations

0