Inflammation and nutritional status in relation to mortality risk from cardio-cerebrovascular events: evidence from NHANES DOI Creative Commons
Chengzhi Hou, Xuanchun Huang,

Jie Wang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 12, 2024

Objective Inflammation and nutritional status are closely associated with the mortality risk of survivors cardio-cerebrovascular events. This study aims to evaluate relationship between inflammation indices among, identifying most predictive indices. Methods included cohort data major adverse cardiovascular cerebrovascular events (MACCE) from National Health Nutrition Examination Survey (NHANES) in 1999–2010. MACCE is defined as a composite myocardial infarction, heart failure stroke, at least one three occurs. The main outcomes were all-cause mortality. Kaplan–Meier analysis receiver operating characteristic curves used compare correlation seven inflammatory (such Advanced Lung Cancer Index, ALI) among survivors. A multivariable-adjusted Cox regression restricted cubic splines identified index, optimal number nodes determined by Akaike information criterion. Subgroup sensitivity analyses conducted assess model stability. Results total 2,045 included. higher levels ALI serum albumin significantly lower risks these individuals. Increases C-reactive protein Lymphocyte Ratio, Neutrophil Serum Albumin Neutrophil-to-Lymphocyte Systemic Immune-Inflammation Index (SII), similarly correlated risk. outperformed other indices, displaying distinct L-shaped nonlinear both survivors, an inflection point 90 indicating lowest To left this inflection, each unit increase was 1.3% decrease patients. right, might 0.2%, although change not statistically significant. showed that association remained stable survivor populations. Conclusion Routine dynamic monitoring helpful for clinicians Anti-inflammatory therapies appropriate support crucial reducing

Language: Английский

The gut microbiota and its role in the development of cardiovascular disease DOI
Carlos Escobar, Xavier Aldeguer, David Vivas

et al.

Expert Review of Cardiovascular Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 7, 2025

The pathophysiology of cardiovascular diseases encompasses a complex interplay genetic and environmental risk factors. Even if traditional factors are treated to target, there remains residual risk. This manuscript reviews the potential role gut microbiota in development disease, as target. A systematic search was conducted until 30 October 2024 on PubMed (MEDLINE), using MeSH terms [Gut microbiota] + [Dysbiosis] [Cardiovascular] [TMAO] [bile acids] [short-chain fatty acids]. term dysbiosis implies changes equilibrium, with modifications composition functionality series additional factors: reduced diversity uniformity microorganisms; short-chain acid-producing bacteria; increased permeability; release metabolites, such trimethylamine N-oxide, betaine, phenylalanine, tryptophan-kynurenine, phenylacetylglutamine, lipopolysaccharides; secondary bile acid excretion, leading inflammation, oxidative stress, endothelial dysfunction facilitating onset pathological conditions, including obesity, hypertension, diabetes, atherosclerosis, heart failure. Attempts restore balance through different interventions, mainly diet, have been shown positively affect individual components metabolites reduce disease. In addition, probiotics prebiotics potentially useful. Fecal transplantation is promising therapy.

Language: Английский

Citations

1
The gut-liver axis: emerging mechanisms and therapeutic approaches for nonalcoholic fatty liver disease and type 2 diabetes mellitus DOI
Monika Bhardwaj, Papiya Mitra Mazumder

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Language: Английский

Citations

7
Role of Trimethylamine N-Oxide in Heart Failure DOI Creative Commons

Lele Jing,

Honghong Zhang,

Qiannan Xiang

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(7)

Published: July 2, 2024

Heart failure (HF) is a clinical syndrome characterizing by typical physical signs and symptomatology resulting from reduced cardiac output and/or intracardiac pressure at rest or under stress due to structural functional abnormalities of the heart. HF often final stage all cardiovascular diseases significant risk factor for sudden arrest, death, liver kidney failure. Current pharmacological treatments can only slow progression recurrence HF. With advancing research into gut microbiome its metabolites, one such trimethylamine N-oxide (TMAO)—has been implicated in advancement correlated with poor prognosis patients However, precise role TMAO has not yet clarified. This review highlights concludes available evidence potential mechanisms associated HF, hope contributing new insights diagnosis prevention

Language: Английский

Citations

6
Early oral anti-inflammatory diet in patients with mild acute pancreatitis：study protocol for a randomized controlled trial (Preprint) DOI Creative Commons
Guangping Li

Published: Jan. 8, 2025

BACKGROUND Early oral feeding in patients with mild acute pancreatitis can facilitate early recovery and offer economic benefits such as reduced average length of hospital stay hospitalization costs. However, there is a paucity research on nutritional support protocols for pancreatitis. Anti-inflammatory diets have been shown to decrease inflammatory levels modulate intestinal microbiota, which may confer advantages OBJECTIVE This study aims explore the safety effectiveness introduction an anti-inflammatory diet METHODS single-center randomized controlled trial where experimental group undergoes intervention, while control receives conventional management. The primary outcome measures include biomarkers (C-reactive protein,interleukin-6, interleukin-10, tumor necrosis factor-α, nutrition-related indicators (BMI, body composition, albumin, prealbumin), gut microbiota. Secondary RESULTS enrollment participants commenced December 2024, anticipated completion date July 2025. A comprehensive final analysis outcomes planned October 2025, following collection rigorous evaluation all relevant data. CONCLUSIONS positive findings this novel clinical practice guidelines CLINICALTRIAL Chinese Clinical Trial Registry.gov ChiCTR2400094056；https://www.chictr.org.cn/index.html

Language: Английский

Citations

0
The causal dance: trimethylamine N-oxide, obesity, and acute pancreatitis in pathophysiological harmony DOI
Jie Liu, P. Ge, Yalan Luo

et al.

Human Cell, Journal Year: 2025, Volume and Issue: 38(3)

Published: March 26, 2025

Language: Английский

Citations

0
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy DOI Creative Commons
Vicky Yao,

Nairui Fan,

Shuxia Ma

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 18, 2025

ABSTRACT Dysbiosis refers to the disruption of gut microbiota balance and is pathological basis various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, metabolic abnormalities. These involve dysfunctions in gut–brain axis, gut–liver others cause broader effects. Although association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding specific treatment strategies. This review begins examining causes summarizes potential representative imbalance. It integrates clinical evidence explore preventive therapeutic strategies targeting emphasizing importance understanding dysbiosis. Finally, we summarized development artificial intelligence (AI) research suggested that it will play a critical role future studies on combining multiomics technologies AI further uncover complex drive personalized

Language: Английский

Citations

0
Inflammation and nutritional status in relation to mortality risk from cardio-cerebrovascular events: evidence from NHANES DOI Creative Commons
Chengzhi Hou, Xuanchun Huang,

Jie Wang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 12, 2024

Objective Inflammation and nutritional status are closely associated with the mortality risk of survivors cardio-cerebrovascular events. This study aims to evaluate relationship between inflammation indices among, identifying most predictive indices. Methods included cohort data major adverse cardiovascular cerebrovascular events (MACCE) from National Health Nutrition Examination Survey (NHANES) in 1999–2010. MACCE is defined as a composite myocardial infarction, heart failure stroke, at least one three occurs. The main outcomes were all-cause mortality. Kaplan–Meier analysis receiver operating characteristic curves used compare correlation seven inflammatory (such Advanced Lung Cancer Index, ALI) among survivors. A multivariable-adjusted Cox regression restricted cubic splines identified index, optimal number nodes determined by Akaike information criterion. Subgroup sensitivity analyses conducted assess model stability. Results total 2,045 included. higher levels ALI serum albumin significantly lower risks these individuals. Increases C-reactive protein Lymphocyte Ratio, Neutrophil Serum Albumin Neutrophil-to-Lymphocyte Systemic Immune-Inflammation Index (SII), similarly correlated risk. outperformed other indices, displaying distinct L-shaped nonlinear both survivors, an inflection point 90 indicating lowest To left this inflection, each unit increase was 1.3% decrease patients. right, might 0.2%, although change not statistically significant. showed that association remained stable survivor populations. Conclusion Routine dynamic monitoring helpful for clinicians Anti-inflammatory therapies appropriate support crucial reducing

Language: Английский

Citations

2