Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 484 - 484
Published: April 18, 2024
The
antioxidant
and
anti-inflammatory
effects
of
hormetic
nutrition
for
enhancing
stress
resilience
overall
human
health
have
received
much
attention.
Recently,
the
gut-brain
axis
has
attracted
prominent
interest
preventing
therapeutically
impacting
neuropathologies
gastrointestinal
diseases.
Polyphenols
polyphenol-combined
nanoparticles
in
synergy
with
probiotics
shown
to
improve
gut
bioavailability
blood-brain
barrier
(BBB)
permeability,
thus
inhibiting
oxidative
stress,
metabolic
dysfunction
inflammation
linked
dysbiosis
ultimately
onset
progression
central
nervous
system
(CNS)
disorders.
In
accordance
hormesis,
polyphenols
display
biphasic
dose-response
by
activating
at
a
low
dose
Nrf2
pathway
resulting
upregulation
Foods,
Journal Year:
2024,
Volume and Issue:
13(15), P. 2401 - 2401
Published: July 29, 2024
Food
innovation
that
utilises
agricultural
waste
while
enhancing
nutritional
value
is
important
for
valorisation
and
consumer
health.
This
study
investigated
incorporating
spinach
(
Journal of Dietary Supplements,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: Jan. 10, 2025
Background
Several
epidemiological
studies
and
intervention
trials
have
demonstrated
that
grapes
blueberries,
which
are
rich
in
flavanols,
can
lower
the
risk
of
cardiovascular
disease.
However,
mechanisms
action
these
compounds
remain
unclear
due
to
their
low
bioavailability.
Food & Function,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Differences
in
the
oral
responsiveness
to
bitter
compound
6-n-propylthiouracil
(PROP)
between
taster
(T)
and
non-taster
(NT)
individuals
have
also
been
related
differences
long-lasting
wine
astringency
perception,
which
could
be
linked
dynamics
of
salivary
protein
profile
upon
stimulation,
depending
on
individual
PROP
taste
status
(PTS).
To
check
this,
time-course
changes
early
(30
60
seconds)
after
stimulation
with
a
red
(CRW)
same
tannin-enriched
(TRW)
Ts
NTs
(young
women)
were
tested
by
using
an
untargeted
proteomic
approach.
Results
showed
that
exhibited
more
pronounced
(measured
as
ratio
abundance
before
stimulation),
compared
NTs,
including
proteins
such
cystatins
(SN,
S,
SA
D),
α-amylase,
prolactin
(PIP),
carbonic
anhydrase
VI
(CA-VI)
acid
proline-rich
(aPRP).
These
evident
30
s
(t1)
than
(t2)
exposure
they
higher
magnitude
TRW.
results
suggest
proteome
induced
PTS
might
contribute
explain
variations
perception
over
time.
Open Medicine,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 1, 2025
Flavan-3-ols
(FLs),
astringent
polyphenols,
are
known
to
have
low
bioavailability
and
induce
excessive
sympathetic
nervous
system
activation.
This
study
aimed
compare
the
effects
of
FLs
on
brown,
subcutaneous,
visceral
adipose
tissue
in
mice.
C57BL/6J
male
mice
fed
a
standard
or
high-fat
diet
were
given
water
50
mg/kg
FL
orally
by
gavage
for
2
weeks.
Excised
inguinal,
epididymal
fat
tissues
prepared
frozen
sectioning.
After
hematoxylin
eosin
(HE)
staining,
administration
each
observed,
expression
analysis
mitochondrial
DNA
genes
was
performed.
Repeated
had
no
morphological
brown
fat.
However,
significantly
reduced
cell
size
subcutaneous
induced
appearance
multilocular
structures.
Furthermore,
increased
cytochrome
B
The
results
showed
that
browning
FL-induced
enhancement
nerve
activity
mitochondria
promoted
browning.
changes
observed
other
tissues.
Further
long-term
is
required
analyze
thoroughly.
Open Medicine,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Jan. 1, 2024
Abstract
Mitochondria-derived
reactive
oxygen
species
production
at
a
moderate
physiological
level
plays
fundamental
role
in
the
anti-aging
signaling,
due
to
their
action
as
redox-active
sensors
for
maintenance
of
optimal
mitochondrial
balance
between
intracellular
energy
status
and
hormetic
nutrients.
Iron
regulatory
protein
dysregulation,
systematically
increased
iron
levels,
dysfunction,
consequent
oxidative
stress
are
recognized
underlie
pathogenesis
multiple
neurodegenerative
diseases,
such
Parkinson’s
disease
Alzheimer’s
disease.
Central
pathogenesis,
Nrf2
signaling
dysfunction
occurs
with
disruption
metabolic
homeostasis.
We
highlight
potential
therapeutic
importance
nutritional
polyphenols
substantive
regulators
pathway.
Here,
we
discuss
common
mechanisms
targeting
Nrf2/vitagene
pathway,
novel
strategies
minimize
consequences
neuroinflammation,
generally
associated
cognitive
demonstrate
its
key
neuroprotective
anti-neuroinflammatory
properties,
summarizing
pharmacotherapeutic
aspects
relevant
brain
pathophysiology.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(10), P. e0306680 - e0306680
Published: Oct. 3, 2024
Cocoa
(Theobroma
cacao
L.)
is
the
basic
raw
material
to
produce
chocolate
and
other
derivatives
such
as
cocoa
butter,
powder
liquor
(cocoa
paste),
which
requires
a
fermentation
process
that
affects
its
chemical
composition
sensory
profile.
The
objective
of
this
study
was
monitor
biochemical,
physical
changes
during
beans
in
bean
processing
plants
department
Caquetá,
Colombia.
During
fermentation,
temperature
mass
pH
pulp
were
monitored
at
different
(Sites
ASOACASAN
ASA,
COMICACAO
CMI,
COMCAP
COC).
Also,
two
points
(days
4
7),
properties
determined,
variables
related
bromatological
composition,
polyphenolic
compounds
antioxidant
activity
attributes
sites.
An
increase
dough
found,
however
cotyledon
decreased
fat
moisture
content
varied
with
time.
At
site
level,
total
polyphenol
(TPC),
flavonoids
(TF),
1,1-diphenyl-2-picrylhydrazil
(DPPH)
ferric
reducing
power
(FRAP)
contents
statistically
different,
COC
being
from
TPC
higher
(507
mg
gallic
acid
equivalent
GAE/g
Cocoa)
respect
sites
(<
360
Cocoa).
TF
followed
similar
behavior
TPC,
significant
differences
between
times
for
ASA.
(309.1
catechin/g
cocoa)
CMI
(215.6
ASA
(185.7
cocoa).
Values
DPPH
ranged
5869.3
7781.8
μmol
Trolox/g
FRAP
assay
369.8
606.7
ascorbic
AA/g
among
It
found
time
management
has
impact
on
parameters
(biochemical,
sensory)
beans.
Therefore,
it
necessary
standardize
achieve
quality
product
meets
needs
market.
