Underneath the Gut–Brain Axis in IBD—Evidence of the Non-Obvious DOI Open Access
Lidiya V. Boldyreva, A. A. Evtushenko, Maria Lvova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12125 - 12125

Published: Nov. 12, 2024

The gut–brain axis (GBA) plays a pivotal role in human health and wellness by orchestrating complex bidirectional regulation influencing numerous critical processes within the body. Over past decade, research has increasingly focused on GBA context of inflammatory bowel disease (IBD). Beyond its well-documented effects GBA–enteric nervous system vagus nerve dysregulation, gut microbiota misbalance—IBD also leads to impairments metabolic cellular functions: mitochondrial dysfunction, cationic transport, cytoskeleton dysregulation. These systemic are currently underexplored relation GBA; however, they crucial for cells’ functioning. This review summarizes studies particular mechanisms IBD. Understanding involvement these may help find new therapeutic targets develop approaches improve quality life IBD patients.

Language: Английский

The Involvement of Antioxidants in Cognitive Decline and Neurodegeneration: Mens Sana in Corpore Sano DOI Creative Commons
Claudio Nazzi, Alessio Avenanti, Simone Battaglia

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 701 - 701

Published: June 7, 2024

With neurodegenerative disorders being on the rise, a great deal of research from multiple fields is conducted in order to further knowledge and propose novel therapeutic interventions. Among these investigations, role antioxidants contrasting cognitive decline putting forward interesting promising results. In this review, we aim collect evidence that focused variety antioxidant-rich foods improving or stabilizing functions, memory, Alzheimer’s disease, most common disorder. Specifically, considered collected humans, either through longitudinal studies randomized, placebo-controlled ones, which evaluated performance, memory abilities, progression level neurodegeneration. Overall, despite between study protocols, cohorts participants involved, neuropsychological tests used, investigated antioxidants, there solid trend suggests properties may be helpful hampering older people. Thus, help future will elucidate neuroprotection lead development interventions take into account such findings provide more global approach treating disorders.

Language: Английский

Citations

14
Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health DOI Open Access
Maria Scuto, Miroslava Majzúnová,

Gessica Torcitto

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12155 - 12155

Published: Nov. 12, 2024

The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease. Several bioactive nutrients, including medicinal herbs, flavonoids, bioavailable polyphenol-combined nanoparticles, as well probiotics, vitamin D omega-3 fatty acids, have been shown improve blood-brain barrier (BBB) dysfunction, endogenous neurosteroid homeostasis brain function. These can inhibit oxidative neuroinflammation, which are linked the pathogenesis of various neurological disorders. Interestingly, flavonoids exhibit dose-dependent effects, activating nuclear factor erythroid 2-related 2 (Nrf2) pathway at physiological/low dose (neurohormesis). This leads upregulation antioxidant phase II genes proteins such heme oxygenase-1 (HO-1) sirtuin-1 (Sirt1), activated by curcumin resveratrol, respectively. adaptive neuronal response mechanisms help protect against reactive oxygen species (ROS) neurotoxicity. Impaired Nrf2 hormone signaling exacerbate selective vulnerability neuroinflammatory conditions, contributing onset progression neurodegenerative psychiatric disorders, Alzheimer's disease, anxiety depression other due neurons stress. review focuses on targeting redox regulate BBB damage associated with altered GABAergic neurotransmission. By exploring underlying molecular using innovative technologies, we aim develop promising neuroprotective strategies personalized nutritional neuroregenerative therapies prevent or attenuate ultimately promoting health.

Language: Английский

Citations

9
Enhancement of Cognitive Benefits and Anti-Anxiety Effects of Phytolacca americana Fruits in a Zebrafish (Danio rerio) Model of Scopolamine-Induced Memory Impairment DOI Creative Commons

Lucia‐Florina Popovici,

Ion Brinza, Florentina Gatea

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 97 - 97

Published: Jan. 15, 2025

Phytolacca americana fruits exhibit a wide range of biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. This study aims to investigate the phenolic profile hydroethanolic extracts from both fresh (PEC) dried (PEU) P. using high-performance liquid chromatography (HPLC) evaluate their impact on anxiety-like behavior, memory, oxidative stress, cholinergic status in zebrafish (Danio rerio, Tübingen strain) treated with scopolamine (SCO, 100 μM). Acute administration PEC PEU (0.1, 0.5, 1 mg/L) was conducted for one hour per day. In silico analyses were performed pharmacokinetic characteristics compounds discerned two extracts, platforms such as SwissAdme, Molinspiration, ProToX-III, AdmetLab 3.0, PKCSM, PASS. Anxiety-like behavior memory performance assessed through specific behavioral assays, novel tank test (NTT), light/dark (LD), approach (NAT), Y-maze, object recognition (NOR). Subsequently, activity acetylcholinesterase (AChE) extent stress brain investigated. Our findings suggest that possess anxiolytic effects, alleviating SCO-induced anxiety enhancing cognitive amnesic zebrafish. Furthermore, these demonstrated ability mitigate deficits by inhibiting AChE supporting antioxidant defense mechanisms increased enzymes reduced lipid protein peroxidation. These results highlight potential use fruit managing impairments related dementia conditions.

Language: Английский

Citations

1
Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Marius Turnea

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

Citations

8
Comparison of Transgenerational Neurotoxicity between Pristine and Amino-Modified Nanoplastics in C. elegans DOI Creative Commons

Mingxuan Song,

Qinli Ruan, Dayong Wang

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(8), P. 555 - 555

Published: July 30, 2024

Increasing evidence has suggested that nanoplastic pollution become a global concern. More importantly, transgenerational toxicity can be induced by nanoplastics at predicted environmentally relevant doses (ERDs). Considering amino modification could increase toxicity, we compared neurotoxicity between pristine polystyrene nanoparticle (PS-NP) and amino-modified PS-NP (NH

Language: Английский

Citations

7
Astragalin from Thesium chinense: A Novel Anti-Aging and Antioxidant Agent Targeting IGFR/CD38/Sirtuins DOI Creative Commons
Ruifeng Wang,

Anping Ding,

Jiaye Wang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 859 - 859

Published: July 18, 2024

Astragalin (AG), a typical flavonoid found in Thesium chinense Turcz (T. chinense), is abundant various edible plants and possesses high nutritional value, as well antioxidant antibacterial effects. In this study, we initially predicted the mechanism of action AG with two anti-aging antioxidant-related protein targets (CD38 IGFR) by molecular docking dynamics simulation techniques. Subsequently, examined effects Caenorhabditis elegans (C. elegans), zebrafish, verified related mechanisms. C. elegans, synergistically extended lifespan up-regulating expression daf-16 through inhibiting daf-2/IGFR also activating AMPK MAPK pathways to up-regulate sir-2.1, sir-2.4, skn-1. oxidatively damaged zebrafish embryos, demonstrated synergistic effect augmenting resistance embryos oxidative stress levels SIRT1 SIRT6 within system via suppression CD38 enzymatic activity then IGFR SIRT6. These findings highlight properties indicate its potential application supplementary ingredient aquaculture for enhancing fish health growth.

Language: Английский

Citations

5
E3 ubiquitin ligase TRIM31: A potential therapeutic target DOI Open Access

Nian-Hua Deng,

Zhen Tian,

Ying-Jiao Zou

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116846 - 116846

Published: June 7, 2024

Ubiquitination is a key mechanism for post-translational protein modification, affecting localization, metabolism, degradation and various cellular physiological processes. Dysregulation of ubiquitination associated with the pathogenesis diseases, such as tumors cardiovascular making it primary area interest in biochemical research drug development endeavors. E3 ubiquitin ligases play pivotal role modulating substrate proteins through their unique recognition functions. TRIM31, member TRIM family ligases, aberrantly expressed different pathophysiological conditions. The biological function TRIM31 occurrence diverse diseases. has been demonstrated to inhibit inflammation by promoting ubiquitin-proteasome-mediated sensing NLRP3 inflammasome. mediates MAVS, inducing formation prion-like aggregates, triggering innate antiviral immune responses. also implicated tumor pathophysiology its ability promote suppressor p53. These findings indicate that potential therapeutic target, subsequent in-depth anticipated provide information on clinical application therapy.

Language: Английский

Citations

4
Modulation of Keap-1/Nrf2/HO-1 and NF-ĸB/caspase-3 signaling pathways by Dihydromyricetin Ameliorates Sodium Valproate-Induced Liver Injury DOI

Doaa Emad,

Asmaa M. A. Bayoumi, Sahar M. Gebril

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 758, P. 110084 - 110084

Published: July 4, 2024

Language: Английский

Citations

4
Epigallocatechin-3-Gallate Inhibits Oxidative Stress Through the Keap1/Nrf2 Signaling Pathway to Improve Alzheimer Disease DOI
Shi Tang,

Yong Zhang,

Benson O. A. Botchway

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Language: Английский

Citations

4
The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review DOI Open Access
Beyza Mertaş, İffet İpek Boşgelmez

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1222 - 1222

Published: Jan. 30, 2025

Alzheimer’s disease (AD) is one of the most common and severe forms dementia neurodegenerative disease. As life expectancy increases in line with developments medicine, elderly population projected to increase next few decades; therefore, an prevalence some diseases, such as AD, also expected. a result, until radical treatment becomes available, AD expected be more frequently recorded top causes death worldwide. Given current lack cure for only treatments available being ones that alleviate major symptoms, identification contributing factors influence incidence crucial. In this context, genetic and/or epigenetic factors, mainly environmental, disease-related, dietary, or combinations/interactions these are assessed. review, we conducted literature search focusing on environmental air pollution, toxic elements, pesticides, infectious agents, well dietary including various diets, vitamin D deficiency, social (e.g., tobacco alcohol use), variables affected by both behavior gut microbiota. We evaluated studies beneficial effects antibiotics Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) Mediterranean diets.

Language: Английский

Citations

0