Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3271 - 3271
Published: Sept. 27, 2024
Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health quality life in older adults. This narrative review explores emerging targets potential treatments for sarcopenia, aiming to provide a comprehensive overview current prospective interventions.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1100 - 1100
Published: Jan. 27, 2025
The coordination of cytoskeletal proteins shapes cell architectures and functions. Age-related changes in cellular mechanical properties have been linked to decreased tissue dysfunction. Studies also found a relationship between mitochondrial function the cytoskeleton. Cytoskeleton inhibitors impact quality function, including motility morphology, membrane potential, respiration. regulatory cytoskeleton on functions are involved pathogenesis several diseases. Disassembly axon’s release neurofilament fragments documented during neurodegeneration. However, these can be related impairments, spanning from reduced altered bioenergetics. Herein, we discuss recent research highlighting some pathophysiological roles disassembly aging, neurodegeneration, neuromuscular diseases, with focus studies that explored intermediate filaments signaling as relevant contributors health disease.
Language: Английский
Citations
0
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Aging is an inevitable and complex biological process involving multi-factorial mechanisms. Mitochondrial dysfunction a critical factor in the aging process, characterized by decline mitochondrial quality activity, leading to aging-related diseases. Therefore, mitochondria have become attractive target anti-aging therapies. Several senolytic drugs targeting antioxidant agents been used research past few years. However, these strategies may cause adverse effects with long-term medication. In this extensive review, we propose "mitochondrial transplantation," which transfers healthy from donor cells recipient replace damaged or dysfunctional mitochondria, as new alternative strategy for treating aging-associated introduce contemporary landscape of transplantation, then discuss intensely successful applications transplantation therapy diseases such neurodegenerative diseases, cardiovascular aging, reproductive highlighting its translational potential. Finally, summarize prospect challenges opportunities faces therapy.
Language: Английский
Citations
3
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106477 - 106477
Published: Oct. 7, 2024
Language: Английский
Citations
1
Frontiers in Medical Technology, Journal Year: 2024, Volume and Issue: 6
Published: Oct. 9, 2024
Sarcopenia is a prevalent condition with significant clinical implications, and it expected to escalate globally, demanding for effective diagnostic strategies, possibly at an early stage of the disease. Imaging techniques play pivotal role in comprehensively evaluating sarcopenia, offering insights into both muscle quantity quality. Among all imaging currently used diagnosis follow up possible distinguish two classes: Rx based techniques, using ionizing radiations, non-invasive which are on use safe low risk procedures. Dual-energy x-ray Absorptiometry Computed Tomography, while widely utilized, entail radiation exposure concerns. Ultrasound offers portability, real-time imaging, absence radiation, making promising tool Magnetic Resonance Imaging, particularly T1-weighted Dixon sequences, provides cross- sectional high-resolution images fat-water separation capabilities, facilitating precise sarcopenia quantification. Bioelectrical Impedance Analysis (BIA), technique, estimates body composition, including mass, albeit influenced by hydration status. Standardized protocols, such as those proposed through (SARCUS) Working Group, imperative ensuring consistency across assessments. Future research should focus refining these harnessing potential radiomics artificial intelligence enhance accuracy prognostic capabilities sarcopenia.
Language: Английский
Citations
1
The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(12), P. 100397 - 100397
Published: Oct. 19, 2024
Language: Английский
Citations
1
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117505 - 117505
Published: Nov. 4, 2024
Language: Английский
Citations
0
MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)
Published: Dec. 1, 2024
Abstract Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark sarcopenia cachexia, frequently associated with aging, malignant tumors, chronic heart failure, malnutrition. Moreover, it poses significant challenges to human health, leading increased frailty, reduced quality life, heightened mortality risks. Despite extensive research on consensus in their assessment remains elusive, inconsistent conclusions regarding molecular mechanisms. atrophy models are crucial tools for advancing this field. Currently, animal used clinical basic scientific studies induced through various methods, including genetic editing, nutritional modification, exercise, wasting diseases, drug administration. also include vitro small organism models. value, each these has certain limitations. This review focuses limitations diverse applications understand encourage rational use future research, therefore deepening understanding underlying pathophysiological mechanisms, ultimately exploration therapeutic strategies cachexia.
Language: Английский
Citations
0
Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
0