Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)
Published: Jan. 10, 2025
Abstract Cancer vaccines, crucial in the immunotherapeutic landscape, are bifurcated into preventive and therapeutic types, both integral to combating oncogenesis. Preventive cancer like those against HPV HBV, reduce incidence of virus-associated cancers, while vaccines aim activate dendritic cells cytotoxic T lymphocytes for durable anti-tumor immunity. Recent advancements vaccine platforms, such as synthetic peptides, mRNA, DNA, cellular, nano-vaccines, have enhanced antigen presentation immune activation. Despite US Food Drug Administration approval several full potential remains unrealized due challenges selection, tumor-mediated immunosuppression, optimization delivery systems. This review provides a comprehensive analysis aims implications vaccine, innovative discovery neoantigens enhancing specificity, latest strides platforms. It also critically evaluates role adjuvants immunogenicity mitigating immunosuppressive tumor microenvironment. The further examines synergistic combining with other therapies, chemotherapy, radiotherapy, checkpoint inhibitors, improve outcomes. Overcoming barriers effective identification, microenvironments, adverse effects is critical advancing development. By addressing these challenges, can offer significant improvements patient outcomes broaden scope personalized immunotherapy.
Language: Английский
Citations
2
Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122856 - 122856
Published: Sept. 28, 2024
Language: Английский
Citations
5
Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3254 - 3254
Published: Sept. 24, 2024
Short peptides have been coming around as a strong weapon in the fight against cancer on all fronts—in immuno-, chemo-, and radiotherapy, also combinatorial approaches. Moreover, short relevance imaging or 3D culture. Thanks to natural ‘smart’ nature of peptides, their unique structural features, well recent progress biotechnological bioinformatics development, are playing an enormous role evolving cutting-edge strategies. Self-assembling may create excellent structures stimulate cytotoxic immune responses, which is essential for immunotherapy. can help establish versatile strategies with high biosafety effectiveness. Supramolecular peptide-based vaccines entered clinical trials. Peptide assemblies be platforms delivery antigens, adjuvants, cells, and/or drugs. unappreciated, especially vaccine aspect. Meanwhile, they still hide undiscovered unlimited potential. Here, we provide timely update this highly active fast-evolving field.
Language: Английский
Citations
4
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1170 - 1170
Published: Feb. 11, 2025
Viral infections such as human papillomavirus (HPV) and Epstein–Barr virus (EBV) play a critical role in the onset of oropharyngeal (OPC) nasopharyngeal cancer (NPC), respectively. Despite advancements targeted therapies immunotherapies, recurrent/metastatic setting, these tumors remain incurable diseases with poor prognosis. The development therapeutic tumor vaccines, utilizing either neoantigens or oncoviral antigens, represents promising addition to immunotherapy arsenal. Research on vaccine-based for OPC NPC focuses targeting viral particularly HPV E6/E7 EBV EBNA1/LMP2. potential vaccine platforms, including peptide-based, DNA, RNA, vector-based induce durable immune responses against antigens is reported. early-phase clinical trials evaluating HPV-related EBV-related revealed safety preliminary signs efficacy; however, further are crucial validation. This review provides an overview current landscape strategies NPC, discussing their biological mechanisms processes involved anti-HPV anti-EBV treatments, particular focus factors that influence therapies.
Language: Английский
Citations
0
Current Treatment Options in Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: March 8, 2025
Language: Английский
Citations
0
Advances in immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0