Colloids and Surfaces B Biointerfaces, Journal Year: 2022, Volume and Issue: 211, P. 112316 - 112316
Published: Jan. 4, 2022
Language: Английский
Military Medical Research, Journal Year: 2022, Volume and Issue: 9(1)
Published: Nov. 19, 2022
Abstract Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting variety of cell types, whose activity interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding immune microenvironment processes governing bone, regeneration, clinical translation these mechanisms remains challenge. Regulation increasingly becoming favorable target regeneration; therefore, an in-depth communication between cells functional would valuable. Herein, we review regulatory role promotion maintenance stem states context repair regeneration. We discuss roles various subsets introduce novel strategies, example, biomaterial-targeting activity, aimed at regulating healing. Understanding crosstalk pathways may shed light on new therapeutic opportunities enhancing through regulation microenvironment.
Language: Английский
Citations
181
Ceramics International, Journal Year: 2020, Volume and Issue: 46(10), P. 15725 - 15739
Published: March 19, 2020
Language: Английский
Citations
176
Polymers, Journal Year: 2020, Volume and Issue: 12(4), P. 844 - 844
Published: April 6, 2020
Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, may not provide suitable support cell adhesion, proliferation, and differentiation, which decelerates regeneration. To improve biological properties, frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, cytokines. Although there many papers describing synthesis properties of polymer proteins or few reviews comprehensively summarize these molecules. Thus, this review presents the current knowledge about most important peptides used modification This paper also describes influence addition on physicochemical, mechanical, scaffolds. Moreover, article sums up major applications biodegradable natural synthetic modified have been developed within past five years.
Language: Английский
Citations
155
Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121638 - 121638
Published: June 17, 2022
Language: Английский
Citations
123
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 240, P. 124407 - 124407
Published: April 13, 2023
Language: Английский
Citations
57
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: unknown
Published: March 9, 2023
New conductive materials for tissue engineering are needed the development of regenerative strategies nervous, muscular, and heart tissues. Polycaprolactone (PCL) is used to obtain biocompatible biodegradable nanofiber scaffolds by electrospinning. MXenes, a large class 2D nanomaterials, can make polymer hydrophilic. However, an understanding how their physical properties affect potential biomedical applications still lacking. We immobilized Ti3C2Tx MXene in several layers on electrospun PCL membranes positron annihilation analysis combined with other techniques elucidate defect structure porosity scaffolds. The base was characterized presence nanopores. surface had abundant vacancies at temperatures 305-355 K, voltage resonance 8 × 104 Hz relaxation time 6.5 106 s found 20-355 K temperature interval. appearance long-lived component lifetime observed, which dependent annealing temperature. study conductivity composite wide range, including its inductive capacity components, showed possibility use MXene-coated as biomaterials. electronic defects formed were correlated biological vitro bacterial adhesion tests. Double triple coatings appropriate environment cell attachment proliferation mild antibacterial effects. A combination structural, chemical, electrical, PCL-MXene demonstrated advantage over existing engineering.
Language: Английский
Citations
52
NPG Asia Materials, Journal Year: 2024, Volume and Issue: 16(1)
Published: Jan. 19, 2024
Abstract As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to permanent impairment in patients. Unfortunately, due complex pathological mechanisms and unique postinjury microenvironment, there is currently no way completely repair injured cord. In recent years, with rapid development tissue engineering technology, combination biomaterials medicine has provided a new idea for treating SCI. Here, we systematically summarize representative biomaterials, including natural, synthetic, nano, hybrid materials, their applications SCI treatment. addition, describe several state-of-the-art fabrication techniques engineering. Importantly, provide novel insights use biomaterial-based therapeutic strategies reduce secondary damage promote repair. Finally, discuss biomaterial clinical studies. This review aims reference future exploration regeneration strategies.
Language: Английский
Citations
23
Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(1)
Published: Jan. 1, 2025
ABSTRACT In the human body, bioelectric cues are crucial for tissue stimulation and regeneration. Electrical (ES) significantly enhances regeneration of nerves, bones, cardiovascular tissues, wounds. However, use conventional devices with stimulating metal electrodes is invasive requires external batteries. Consequently, electrically active materials excellent biocompatibility have attracted attention their applications in engineering. To fully exploit potential these materials, biocompatibility, operating mechanisms, electrical properties, even biodegradability should be carefully considered. this review, we categorize various biomaterials based on mechanisms generating cues, such as piezoelectric effect, triboelectric others. We also summarize key material including characteristics biodegradability, describe musculoskeletal tissues. The hold great advancing field engineering demonstrated success underscores importance continued research field.
Language: Английский
Citations
3
Polymers, Journal Year: 2021, Volume and Issue: 13(24), P. 4368 - 4368
Published: Dec. 13, 2021
Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine a developing biomedical field with the potential to decrease need for organ transplant. Wound management challenging, particularly chronic injuries, despite availability of various types wound dressing scaffolds in market. Some dressings that are clinical practice have drawbacks such as poor antibacterial and antioxidant efficacy, mechanical properties, inability absorb excess exudates, require frequent change fails offer suitable moist environment accelerate healing process. Collagen biopolymer major constituent extracellular matrix (ECM), making it interesting polymer development dressings. Collagen-based nanofibers demonstrated properties advantageous both arena skin dressings, low antigenicity, good biocompatibility, hemostatic capability promote cellular proliferation adhesion, non-toxicity. Hence, review will discuss outcomes collagen-based reported from series preclinical trials healing.
Language: Английский
Citations
103
Biotechnology Journal, Journal Year: 2020, Volume and Issue: 15(12)
Published: July 12, 2020
Emerging biomaterials for tissue engineering applications witness a multitude of interaction (both along their interface and internally) with human tissue. Insufficient consideration the spatial temporal aspects these biomaterial-tissue interactions often raise biocompatibility concerns. This review focuses on strategies implemented in some recently developed biomaterials-particularly soft hard regeneration or replacement-to overcome potential foreign body response ensure effective functioning biomaterial.
Language: Английский
Citations
89