Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota DOI Open Access
Ewa Baranowska‐Wójcik,

Anna Winiarska‐Mieczan,

Piotr Olcha

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 681 - 681

Published: Feb. 28, 2024

Dysbiosis of the microbiota in gastrointestinal tract can induce development gynaecological tumours, particularly postmenopausal women, by causing DNA damage and alterations metabolite metabolism. also complicates cancer treatment influencing body’s immune response disrupting sensitivity to chemotherapy drugs. Therefore, it is crucial maintain homeostasis gut through effective use food components that affect its structure. Recent studies have shown polyphenols, which are likely be most important secondary metabolites produced plants, exhibit prebiotic properties. They structure synthesis metabolites. In this review, we summarise current state knowledge, focusing on impact polyphenols endometrial cancer, emphasising polyphenol consumption leads beneficial modifications microbiota.

Language: Английский

Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders DOI Creative Commons
Janet M. Sasso, Ramy M. Ammar,

Rumiana Tenchov

et al.

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(10), P. 1717 - 1763

Published: May 8, 2023

Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that gut and brain are in constant bidirectional communication, which its metabolic production major component, form so-called microbiome–brain axis. Disturbances homeostasis caused by imbalance their functional composition activities, known as dysbiosis, cause dysregulation these pathways trigger changes blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological disorders. In turn, can affect structure function through autonomic nervous system regulating motility, intestinal transit secretion, permeability. Here, we examine data from CAS Content Collection, largest published scientific information, analyze publication landscape recent research. We review advances knowledge related to human microbiome, complexity functionality, communication with central system, effect axis on mental health. discuss correlations between various diseases, specifically also explore metabolites regard impact associated diseases. Finally, assess clinical applications gut-microbiota-related substances development pipelines. hope this serve useful resource understanding current emerging field an effort further solving remaining challenges fulfilling potential.

Language: Английский

Citations

97
Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature DOI Creative Commons
Alessio Danilo Inchingolo, Giuseppina Malcangi, Alexandra Semjonova

et al.

Children, Journal Year: 2022, Volume and Issue: 9(7), P. 1014 - 1014

Published: July 8, 2022

The oral microbiota plays a vital role in the human microbiome and health. Imbalances between microbes their hosts can lead to systemic disorders such as diabetes or cardiovascular disease. purpose of this review is investigate literature evidence dysbiosis on health discuss current knowledge emerging mechanisms governing polymicrobial synergy dysbiosis; both have enhanced our understanding pathogenic aided design innovative therapeutic approaches ORALBIOTICA for diseases demineralization. PubMed, Web Science, Google Scholar, Scopus, Cochrane Library, EMBEDDED, Dentistry & Oral Sciences Source via EBSCO, APA PsycINFO, PsyArticles, DRUGS@FDA were searched publications that matched topic from January 2017 22 April 2022, with an English language constraint using following Boolean keywords: ("microbio*" "demineralization*") AND ("oral microbiota" "demineralization"). Twenty-two studies included qualitative analysis. As seen by review, balance unstable influenced hygiene, presence orthodontic devices cavity poor eating habits modify its composition behavior positive negative ways, increasing development demineralization, caries processes, periodontal Under conditions dysbiosis, favored acidic environment, reproduction specific bacterial strains increases, favoring cariogenic ones Bifidobacterium dentium, longum,

Language: Английский

Citations

73
Microbiota revolution: How gut microbes regulate our lives DOI Creative Commons
Marica Colella, Ioannis Alexandros Charitos, Andrea Ballini

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(28), P. 4368 - 4383

Published: July 26, 2023

The human intestine is a natural environment ecosystem of complex diversified and dynamic microorganisms, determined through process competition selection during life. Those intestinal microorganisms called microbiota are involved in variety mechanisms the organism, they interact with host therefore contact organs various systems. However, play crucial role maintaining homeostasis, also influencing its behaviour. Thus, perform series biological functions important for well-being. provides nutrients, simultaneously drawing many benefits such as their contribution to metabolic, trophic, immunological, other functions. For these reasons it has been reported that quantitative qualitative composition can protective or harmful on health. Therefore, dysbiosis lead an association unfavourable factors which dysregulation physiological processes homeostasis. pre-viously noted gut participate pathogenesis autoimmune diseases, chronic inflammation, diabetes mellitus, obesity atherosclerosis, neurological disorders (e.g., autism, etc.) colorectal cancer, more.

Language: Английский

Citations

68
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus DOI Open Access
Monika Martiniaková, Anna Šarocká,

Noémi Pénzes

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 275 - 275

Published: Jan. 13, 2025

Type 2 diabetes mellitus (T2DM), a serious metabolic disorder, is worldwide health problem due to the alarming rise in prevalence and elevated morbidity mortality. Chronic hyperglycemia, insulin resistance, ineffective effect secretion are hallmarks of T2DM, leading many secondary complications. These include, particular, cardiovascular disorders, diabetic neuropathy, nephropathy retinopathy, foot, osteoporosis, liver damage, susceptibility infections some cancers. Polyphenols such as flavonoids, phenolic acids, stilbenes, tannins, lignans constitute an extensive heterogeneous group phytochemicals fresh fruits, vegetables their products. Various vitro studies, animal model studies available clinical trials revealed that flavonoids (e.g., quercetin, kaempferol, rutin, epicatechin, genistein, daidzein, anthocyanins), acids chlorogenic, caffeic, ellagic, gallic curcumin), stilbenes resveratrol), tannins procyanidin B2, seaweed phlorotannins), pinoresinol) have ability lower enhance sensitivity improve secretion, scavenge reactive oxygen species, reduce chronic inflammation, modulate gut microbiota, alleviate complications T2DM. The interaction between polyphenols conventional antidiabetic drugs offers promising strategy management treatment especially advanced disease stages. Synergistic effects with been documented, but also antagonistic interactions may impair drug efficacy. Therefore, additional research required clarify mutual order use knowledge applications. Nevertheless, dietary can be successfully applied part supportive for they both obvious symptoms

Language: Английский

Citations

4
Understanding the Role of the Gut Microbiome in Diabetes and Therapeutics Targeting Leaky Gut: A Systematic Review DOI Open Access

Aishwarya Sadagopan,

Anas Mahmoud,

Maha Begg

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: July 8, 2023

The gut microbiota has been studied and continues to be a developing area in the pathognomic development of metabolic diseases like diabetes. Treatment with diet changes, addition supplements prebiotics/probiotics, impact fecal microbial transplantation can correlated targeting changes dysbiosis. Understanding impacts various anti-hyperglycemic agents such as metformin implications post-bariatric surgery on diversity emerged. These areas study are crucial understanding aspects diabetes disease progression at level inflammatory mechanisms, which may give more insight into focusing role prebiotic/probiotic potential forms prospective management that target microbiota, harbors low-grade inflammation. Intestinal dysbiosis was consistently observed mechanism change diabetic individuals, contributing reduced insulin sensitivity poor glycemic control. This systematic review carried out using Preferred Reporting Items for Systematic Reviews Meta-analyses (PRISMA) 2020 checklist. We performed literature search PubMed, Google Scholar Science Direct databases accordance eligibility criteria ultimately selected 14 articles final analysis. Scale Assessment Narrative Review Articles (SANRA) PRISMA checklist were used assess quality cross-sectional studies, traditional reviews, respectively. collected papers from 2012 2022 this review. gathered databases, study, show there is strong connection between appears exist. objective identify any dietary therapeutic alter potentially modulate sensitivity. article will discuss pathophysiological effects biodiversity therapeutics aid reversing

Language: Английский

Citations

24
View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences DOI Creative Commons
Guglielmina Froldi

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 478 - 478

Published: April 8, 2024

Metformin is a synthetic biguanide used as an antidiabetic drug in type 2 diabetes mellitus, achieved by studying the bioactive metabolites of Galega officinalis L. It also off-label for various other diseases, such subclinical diabetes, obesity, polycystic ovary syndrome, etc. In addition, metformin proposed add-on therapy several conditions, including autoimmune neurodegenerative and cancer. Although has been many decades, it still subject pharmacodynamic pharmacokinetic studies light its extensive use. acts at mitochondrial level inhibiting respiratory chain, thus increasing AMP/ATP ratio and, subsequently, activating AMP-activated protein kinase. However, mechanisms have proposed, binding to presenilin enhancer 2, GLP1 release, modification microRNA expression. Regarding pharmacokinetics, after oral administration, absorbed, distributed, eliminated, mainly through renal route, using transporters cationic solutes, since exists ionic molecule physiological pH. this review, particular consideration paid literature data from last 10 years, deepening study clinical trials inherent new uses metformin, differences effectiveness safety observed between sexes, unwanted side effects. For objective, was evaluated both VigiBase EudraVigilance, respectively, WHO European databases reported adverse reactions, assess extent effects real-life

Language: Английский

Citations

15
Isolation, structural, biological activity and application of Gleditsia species seeds galactomannans DOI

Jiaqi Sang,

Gang Zhao, Anastasios Koidis

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122019 - 122019

Published: March 5, 2024

Language: Английский

Citations

11
Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis DOI

Igor Henrique Rodrigues de Paiva,

Rodrigo Soares da Silva,

Ingrid Prata Mendonça

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2024, Volume and Issue: 19(1)

Published: July 23, 2024

Language: Английский

Citations

10
Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review DOI Open Access

Nicoleta Mihaela Mindrescu,

Cristian Guja, Viorel Jinga

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3540 - 3540

Published: March 21, 2024

The intestinal microbiota refers to the collection of microorganisms that exist in human gut. It has been said bacteria influence development metabolic diseases, such as diabetes mellitus, they have roles immunomodulation, protection against pathogens, blood vessel growth, repairing wall, and neurological system. In this review, we look at latest research regarding interactions between gut oral antihyperglycemic drugs present data suggesting microbiome may help counteract reduced glucose tolerance insulin resistance associated with disorders. We found antidiabetic can significant impacts on composition function, potentially influencing both efficacy side effects these medications. Additionally, discovered microbial-based therapeutics, including probiotics, prebiotics, postbiotics, fecal be considered when discussing preventive measures personalized treatment options for type 2 mellitus. Understanding how modulate function is essential optimizing their therapeutic minimizing potential adverse effects. relationship glycemic agents, not fully understood, currently subject increasing discussion. proven impact effectiveness medications, but further field uncover novel strategies other disorders by targeting microbiota.

Language: Английский

Citations

9
Updated Progress on Polysaccharides with Anti-Diabetic Effects through the Regulation of Gut Microbiota: Sources, Mechanisms, and Structure–Activity Relationships DOI Creative Commons

Xiaoyu Zhang,

Jia Wang, Tingting Zhang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 456 - 456

Published: April 2, 2024

Diabetes mellitus (DM) is a common chronic metabolic disease worldwide. The disturbance of the gut microbiota has complex influence on development DM. Polysaccharides are one type most important natural components with anti-diabetic effects. Gut can participate in fermentation polysaccharides, and through this, polysaccharides regulate improve This review begins by summary sources, effects regulation functions polysaccharides. Then, mechanisms regulating to exert structure–activity relationship summarized. It found that from plants, fungi, marine organisms show great hypoglycemic activities functions. mainly include repairing burrier, reshaping composition, changing metabolites, anti-inflammatory activity immune function, signal pathways. Structural characteristics such as monosaccharide molecular weight, glycosidic linkage, provides reference for exploration

Language: Английский

Citations

8