Archives of Oral Biology, Journal Year: 2025, Volume and Issue: 175, P. 106278 - 106278
Published: May 3, 2025
Language: Английский
Antibiotics, Journal Year: 2022, Volume and Issue: 11(6), P. 718 - 718
Published: May 26, 2022
Candida species, belonging to commensal microbial communities in humans, cause opportunistic infections individuals with impaired immunity. Pathogens encountered more than 90% cases of invasive candidiasis include C. albicans, glabrata, krusei, tropicalis, and parapsilosis. The most frequently diagnosed infection is candidemia. About 50% candidemia result deep-seated due hematogenous spread. sensitivity blood cultures autopsy-proven ranges from 21% 71%. Non-cultural methods (beta-D-glucan, T2Candida assays), especially beta-D-glucan combination procalcitonin, appear promising the exclusion high (98%) negative predictive value (95%). There currently a clear deficiency approved sensitive precise diagnostic techniques. Omics technologies seem promising, though require further development study. Therapeutic options for are generally limited four classes systemic antifungals (polyenes, antimetabolite 5-fluorocytosine, azoles, echinocandins) two latter being highly effective well-tolerated hence widely used. Principles treatment discussed this review. emergence pan-drug-resistant auris strains indicates an insufficient choice available medications. Further surveillance, alongside therapeutic methods, essential.
Language: Английский
Citations
118
npj Biofilms and Microbiomes, Journal Year: 2024, Volume and Issue: 10(1)
Published: Feb. 24, 2024
Dental caries, a highly prevalent oral disease, impacts significant portion of the global population. Conventional approaches that indiscriminately eradicate microbes disrupt natural equilibrium microbiota. In contrast, biointervention strategies aim to restore this balance by introducing beneficial microorganisms or inhibiting cariogenic ones. Over past three decades, microbial preparations have garnered considerable attention in dental research for prevention and treatment caries. However, unlike related pathologies gastrointestinal, vaginal, respiratory tracts, caries occurs on hard tissues such as tooth enamel is closely associated with localized acid overproduction facilitated biofilms. Therefore, it insufficient rely solely previous mechanisms delineate role cavity. A more comprehensive perspective should involve considering concepts This review elucidates latest progress, action, challenges, future directions regarding probiotics, prebiotics, synbiotics, postbiotics taking into account unique pathogenic With an enhanced understanding microbiota, personalized therapy will emerge critical trend.
Language: Английский
Citations
34
Bioactive Materials, Journal Year: 2022, Volume and Issue: 24, P. 1 - 19
Published: Dec. 9, 2022
Smart biomaterials can sense and react to physiological or external environmental stimuli (e.g., mechanical, chemical, electrical, magnetic signals). The last decades have seen exponential growth in the use development of smart dental for antimicrobial applications dentistry. These biomaterial systems offer improved efficacy controllable bio-functionalities prevent infections extend longevity devices. This review article presents current state-of-the-art design, evaluation, advantages, limitations bioactive stimuli-responsive autonomous materials applications. First, importance classification are discussed. Second, categories bioresponsive antibacterial systematically itemized based on different stimuli, including pH, enzymes, light, field, vibrations. For each category, their mechanism, applications, examples Finally, we examined obstacles required develop clinically relevant these appealing technologies.
Language: Английский
Citations
70
Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14
Published: May 18, 2023
Dental caries is a common oral disease. In many cases, disruption of the ecological balance cavity can result in occurrence dental caries. There are cariogenic microbiota and factors, their identification allows us to take corresponding prevention control measures. With development microbiology, caries-causing bacteria have evolved from traditional single Streptococcus mutans discovery symbiotic bacteria. Thus it necessary systematically organized association polymicrobial interactions with development. terms ecology, occurs due an imbalance microbiota, caused by growth reproduction external factors or homeostasis one’s own factors. To reduce effectively, considering latest scientific viewpoints, may be viewed perspective preventive measures taken; hence, this article summarizes treatment aspects perspectives, particular biofilm formation, bacterial quorum sensing, main
Language: Английский
Citations
40
Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2749 - 2749
Published: Oct. 11, 2023
The human oral microbiome has emerged as a focal point of research due to its profound implications for health. involvement short-chain fatty acids in composition, health, and chronic inflammation is gaining increasing attention. In this narrative review, the results early vitro, vivo, pilot clinical studies projects are presented order define boundaries new complicated issue. According results, current data disputable ambiguous. When investigating role SCFAs health disease, it crucial distinguish between their local GI effects systemic influences. Locally, part normal microbiota metabolism, but increased formation usually attribute dysbiosis; excess participate development diseases biota gut colonization dysbiosis. On other hand, number have established positive impact on whole, including reduction inflammation, improvement metabolic processes, decrease some types cancer incidence. Thus, complex sophisticated approach with consideration origin localization SCFA function assessment demanded. Therefore, more research, especially needed investigate relationship disease potential prevention treatment.
Language: Английский
Citations
28
Biomedicines, Journal Year: 2022, Volume and Issue: 10(6), P. 1298 - 1298
Published: June 1, 2022
To test probiotic therapy for osteoarthritis (OA), we administered Lactobacillus acidophilus (LA) by oral gavage (2×/week) after induction of OA partial medial meniscectomy (PMM). Pain was assessed von Frey filament and hot plate testing. Joint pathology pain markers were comprehensively analyzed in knee joints, spinal cords, dorsal root ganglia distal colon Safranin O/fast green staining, immunofluorescence microscopy RT-qPCR. LA acutely reduced inflammatory joint prevented further progression. The therapeutic efficacy supported a significant reduction cartilage-degrading enzymes, factors the tissues examined. This finding suggests likely clinical effect on OA. treatment fecal microbiome 16S rRNA gene amplicon sequencing analysis. significantly altered microbiota compared to vehicle-treated mice (PERMANOVA p < 0.009). Our pre-clinical animal model revealed disease modifying effects as reflected rapid reduction, cartilage protection, reversal dysbiosis. findings suggest that has beneficial systemic can potentially be developed safe disease-modifying drug (OADMD).
Language: Английский
Citations
37
IBRO Neuroscience Reports, Journal Year: 2023, Volume and Issue: 14, P. 210 - 234
Published: Feb. 10, 2023
Some of the greatest challenges in medicine are neurodegenerative diseases (NDs), which remain without a cure and mostly progress to death. A companion study employed toolkit methodology document 2001 plant species with ethnomedicinal uses for alleviating pathologies relevant NDs, focusing on its relevance Alzheimer's disease (AD). This aimed find plants therapeutic bioactivities range NDs. 1339 were found have bioactivity from literature NDs such as Parkinson's disease, Huntington's AD, motor neurone diseases, multiple sclerosis, prion Neimann-Pick glaucoma, Friedreich's ataxia Batten disease. 43 types found, reducing protein misfolding, neuroinflammation, oxidative stress cell death, promoting neurogenesis, mitochondrial biogenesis, autophagy, longevity, anti-microbial activity. Ethno-led selection was more effective than random species. Our findings indicate that provide large resource ND potential. The extensive validate usefulness mining this data. We number documented able modulate molecular mechanisms underlying various key pathologies, revealing promising even profound capacity halt reverse processes neurodegeneration.
Language: Английский
Citations
19
Metabolites, Journal Year: 2024, Volume and Issue: 14(5), P. 277 - 277
Published: May 10, 2024
In recent years, salivary metabolome studies have provided new biological information and biomarkers to diagnose different diseases at early stages. The saliva in the oral cavity is influenced by many factors that are reflected metabolite profile. Oral microbes can alter profile may express inflammation or diseases. released microbial metabolites represent altered biochemical pathways cavity. This review highlights its use as a diagnostic biofluid for importance of produced risk their possible relationship carcinogenesis discussed.
Language: Английский
Citations
9
Bacteria, Journal Year: 2025, Volume and Issue: 4(1), P. 1 - 1
Published: Jan. 2, 2025
The cat oral microbiome plays an important role in maintaining host health, yet little is known about how to apply microbial data a clinical setting. One such use of signatures cases feline chronic gingivostomatitis (FCGS), severe debilitating complex disease the cavity. FCGS-afflicted cats have limited treatment options, and individual patient responses are needed. In this work, we used deep sequencing total RNA chronicle changes that accompanied cat’s change from treatment-non-responsive treatment-responsive within 17-month span. composition two time points differed point, with notable shifts abundance Myscoplasmopsis, Aspergillus, Capnocytophaga species. Intriguingly, presence fungal groups Aspergillus Candida primarily differentiated non-responsive microbiomes. Associated responder status were multiple species, including sp. H2931, gingivalis, canimorsus. observation tandem by response FCGS suggests potential for evaluations This work contributes developing improved molecular diagnostics enhanced efficacy individualized plans improve disease.
Language: Английский
Citations
1
International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(1), P. 72 - 72
Published: Jan. 8, 2025
Caries and periodontitis affect a significant part of the global population. Regular oral hygiene, sugar restriction, fluoride exposure are main avenues for maintenance health, but adjunctive use prebiotics probiotic bacteria has gained attention over past decades. The microbial clinical effects these biological interventions have been thoroughly covered in systematic reviews. However, combination probiotics (synbiotics) may boost benefits, postbiotics, being inanimate microorganisms, can, when added to hygiene products, offer sustainable option. aim this narrative review was summarize trials on synbiotics postbiotics prevention management dental caries, gingivitis, periodontitis. We searched two databases (PubMed Google Scholar) relevant literature, we identified 17 papers, five caries 12 with periodontal endpoints. found emerging evidence low certainty that lozenges/tablets containing or could reduce incidence preschool schoolchildren comparison standard preventive care. effect adult patients plaque-induced gingivitis less consistent. For adults periodontitis, synbiotic postbiotic products seemed enhance outcome conventional scaling root planning. In conclusion, both non-communicable diseases, closely associated an unbalanced biofilm, application modulators, including display promising beneficial warrant further research.
Language: Английский
Citations
1