Osteologie/Osteology,
Journal Year:
2024,
Volume and Issue:
33(02), P. 67 - 73
Published: May 1, 2024
Zusammenfassung
Aktuell
verfügbaren
pharmakologischen
Therapien
zur
Behandlung
der
Osteoporose
verfolgen
entweder
einen
antiresorptiven
oder
osteoanabolen
Ansatz
sind
dual
wirksam.
Antiresorptive
(Bisphosphonate,
Denosumab,
Östrogene
und
selektive
Östrogenrezeptormodulatoren
(SERMs))
erhöhen
die
Knochenmasse
durch
Hemmung
Knochenresorption.
Osteoanabole
(Teriparatid
Abaloparatid)
Stimulierung
Knochenbildung.
Als
wirksam
gilt
Romosozumab.
In
diesem
Übersichtsartikel
werden
aktuellen
Therapieformen
bei
ihre
Wirkmechanismen
vorgestellt.
Darüber
hinaus
neue
Behandlungsansätze
besprochen,
wie
Einsatz
mesenchymaler
Stammzellen
(MSCs),
Extrazellulärer
Vesikel
(EVs),
Blockierung
des
follikelstimulierenden
Hormons
(FSH)
sowie
eine
individuelle
Anpassung
Bisphosphonat-Dosis.
Cells,
Journal Year:
2023,
Volume and Issue:
12(12), P. 1604 - 1604
Published: June 11, 2023
The
liver
performs
a
multitude
of
bodily
functions,
whilst
retaining
the
ability
to
regenerate
damaged
tissue.
In
this
review,
we
discuss
sex
steroid
biology,
regulation
mammalian
physiology
and
development
new
model
systems
improve
our
understanding
biology
in
health
disease.
A
major
risk
factor
for
disease
is
hepatic
fibrosis.
Key
drivers
process
are
metabolic
dysfunction
pathologic
activation
immune
system.
Although
non-alcoholic
fatty
(NAFLD)
largely
regarded
as
benign,
it
does
progress
steatohepatitis
subset
patients,
increasing
their
developing
cirrhosis
hepatocellular
carcinoma.
NAFLD
susceptibility
varies
across
population,
with
obesity
insulin
resistance
playing
strong
role
development.
Additionally,
age
have
been
identified
important
factors.
addition
biochemistry,
hormones
also
regulate
system,
sexual
dimorphism
described
both
innate
adaptive
responses.
Therefore,
differences
metabolism,
immunity
interplay
factors
consider
when
designing,
studying
therapeutic
strategies
treat
human
purpose
review
provide
reader
general
overview
physiology.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2023,
Volume and Issue:
149, P. 105191 - 105191
Published: April 20, 2023
Endogenous
neurosteroids
and
synthetic
neuroactive
steroids
(NAS)
are
important
targets
for
therapeutic
development
in
neuropsychiatric
disorders.
These
modulate
major
signaling
systems
the
brain
intracellular
processes
including
inflammation,
cellular
stress
autophagy.
In
this
review,
we
describe
studies
performed
using
unnatural
enantiomers
of
key
neurosteroids,
which
physiochemically
identical
to
their
natural
counterparts
except
rotation
polarized
light.
led
insights
how
NAS
interact
with
receptors,
ion
channels
sites
action.
Certain
effects
show
high
enantioselectivity,
consistent
actions
chiral
environments
likely
direct
interactions
proteins.
Other
no
enantioselectivity
even
reverse
enantioselectivity.
The
spectrum
raises
possibility
that
these
agents,
once
considered
only
as
tools
preclinical
studies,
have
potential
complements
some
cases
may
exceed
counterparts.
Here
review
from
perspective
novel
neurotherapeutics.
Reproduction in Domestic Animals,
Journal Year:
2025,
Volume and Issue:
60(3)
Published: March 1, 2025
Phytoestrogens
are
secondary
plant
metabolites
that
structurally
analogous
to
endogenous
oestrogens
and
bind
Bovine
G
Protein-Coupled
Receptors
(GPCRs)
in
animals.
Their
interaction
with
GPCRs
activates
intracellular
signalling
cascades,
such
as
the
cAMP/PKA
pathway,
which
plays
a
crucial
role
ovarian
follicle
development
luteinisation.
These
interactions
may
enhance
reproductive
performance
by
improving
fertility,
synchronising
estrous
cycles,
promoting
ovulation.
also
influence
regularity
timing
of
cycle,
offering
potential
applications
synchronisation
management.
In
this
study,
molecular
docking
was
conducted
on
12,000
phytochemicals
identify
GPCR
ligands.
From
extensive
screening,
five
compounds
highest
binding
affinities
were
selected.
Notably,
Genistein
Apigenin
emerged
top
candidates,
scores
(-8.58
kcal/mol
-8.27
kcal/mol)
lower
RMSD
values
(0.69
1.30)
compared
synthetic
agonists
Estradiol
(-6.07
1.02),
respectively.
Molecular
dynamics
simulations
(MDS)
confirmed
stability
these
phytoestrogen
-GPCR
complexes,
suggesting
effective
sustained
interactions.
The
screened
phytoestrogens
demonstrated
favourable
pharmacokinetic
profiles,
including
non-toxicity,
non-carcinogenicity,
high
gastrointestinal
absorption,
positioning
them
viable
candidates
for
enhancing
dairy
cattle
through
modulation.
findings
suggest
could
be
used
feed
additives
improve
outcomes,
novel
approach
modulate
pathways
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(4), P. 982 - 982
Published: April 17, 2025
Background/Objectives:
Prenatal
hypoxia
(PH)
is
a
leading
cause
of
nervous
system
disorders
in
early
childhood
and
subsequently
leads
to
decline
the
cognitive
mnemonic
functions
central
(such
as
memory
impairment,
reduced
learning
ability,
information
processing).
It
also
increases
anxiety
risk
brain
adulthood.
Compensatory–adaptive
mechanisms
mother–placenta–fetus
system,
which
enhance
fetus’s
CNS
resilience,
are
known,
including
activation
endogenous
neuroprotection
response
hypoxic
injury
through
pharmacological
modulation
HSP70.
Methods:
To
evaluate
effect
HSP70
modulators—Cerebrocurin,
Angiolin,
Tamoxifen,
Glutaredoxin,
Thiotriazoline,
HSF-1
(heat
shock
factor
1
protein),
well
Mildronate
Mexidol—on
motor
skills,
exploratory
behaviors,
psycho-emotional
activities,
learning,
memories
offspring
after
PH.
Experimental
PH
was
induced
by
daily
intraperitoneal
injections
sodium
nitrite
solution
into
pregnant
female
rats
from
16th
21st
day
pregnancy
at
dose
50
mg/kg.
The
newborns
received
Angiolin
(50
mg/kg),
Thiotriazoline
Mexidol
(100
Cerebrocurin
(150
µL/kg),
L-arginine
(200
Glutaredoxin
µg/kg),
or
mg/kg)
for
30
days.
At
month,
were
tested
open
field
test,
2
months,
they
trained
working
spatial
radial
maze.
Results:
Modeling
led
persistent
impairments
activity,
behavior,
decrease
cognitive–mnestic
CNS.
found
that
had
most
pronounced
effects
on
indicators
activity
status
1-month-old
animals
They
exhibited
significant
cognitive-enhancing
memory-supporting
during
training
evaluation
skill
retention
maze
2-month-old
Conclusions:
first
time,
we
obtained
experimental
data
modulators
following
intrauterine
hypoxia.
Based
results
this
study,
identified
agents
promising
neuroprotective
perinatal
Cells,
Journal Year:
2023,
Volume and Issue:
12(11), P. 1486 - 1486
Published: May 27, 2023
Sex
hormones
and
genes
on
the
sex
chromosomes
are
not
only
key
factors
in
regulation
of
sexual
differentiation
reproduction
but
they
also
deeply
involved
brain
homeostasis.
Their
action
is
crucial
for
development
brain,
which
presents
different
characteristics
depending
individuals.
The
role
these
players
fundamental
maintenance
function
during
adulthood
as
well,
thus
being
important
with
respect
to
age-related
neurodegenerative
diseases.
In
this
review,
we
explore
biological
analyze
its
impact
predisposition
toward
progression
particular,
focus
Parkinson’s
disease,
a
disorder
that
has
higher
incidence
male
population.
We
report
how
encoded
by
could
protect
from
disease
or
alternatively
predispose
development.
finally
underline
importance
considering
when
studying
physiology
pathology
cellular
animal
models
order
better
understand
etiology
develop
novel
tailored
therapeutic
strategies.
