Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1775 - 1775
Published: Aug. 6, 2024
The
aim
of
the
project
was
to
evaluate
association
between
selenium
(Se)
and
zinc
(Zn)
levels
in
blood
serum
kidney
cancer
mortality.
In
a
prospective
group
284
consecutive,
unselected
patients
with
cancer,
we
evaluated
their
10-year
survival
rate
relation
Se
Zn
serum.
Micronutrient
were
measured
using
an
inductively
coupled
plasma
mass
spectrometer.
Patients
divided
into
quartiles
based
on
distribution
arranged
increasing
order.
following
variables
taken
account
multivariable
models:
age
at
diagnosis,
gender,
smoking,
type
surgery
histopathological
examination
results.
We
observed
statistically
significant
all-cause
mortality
when
subgroups
low
compared
high
(HR
=
7.74;
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1346 - 1346
Published: April 27, 2023
Immunotherapy
is
among
the
most
effective
approaches
for
treating
cancer.
One
of
key
aspects
successful
immunotherapy
to
achieve
a
strong
and
stable
antitumor
immune
response.
Modern
checkpoint
therapy
demonstrates
that
cancer
can
be
defeated.
However,
it
also
points
out
weaknesses
immunotherapy,
as
not
all
tumors
respond
co-administration
different
immunomodulators
may
severely
limited
due
their
systemic
toxicity.
Nevertheless,
there
an
established
way
through
which
increase
immunogenicity
immunotherapy-by
use
adjuvants.
These
enhance
response
without
inducing
such
severe
adverse
effects.
well-known
studied
adjuvant
strategies
improve
efficacy
metal-based
compounds,
in
more
modern
implementation-metal-based
nanoparticles
(MNPs),
are
exogenous
agents
act
danger
signals.
Adding
innate
activation
main
action
immunomodulator
makes
capable
eliciting
robust
anti-cancer
The
has
peculiarity
local
administration
drug,
positively
affects
its
safety.
In
this
review,
we
will
consider
MNPs
low-toxicity
adjuvants
could
provide
abscopal
effect
when
administered
locally.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Feb. 4, 2025
The
diagnosis
and
treatment
of
non-small
cell
lung
cancer
in
clinical
settings
face
serious
challenges,
particularly
due
to
the
lack
integration
between
two
processes,
which
limit
real-time
adjustments
plans
based
on
patient's
condition
drive-up
costs.
Here,
we
present
a
multifunctional
pH-sensitive
core-shell
nanoparticle
containing
quercetin
(QCT),
termed
AHA@MnP/QCT
NPs,
designed
for
simultaneous
cancer.
Mechanistic
studies
indicated
that
QCT
Mn2+
exhibited
excellent
peroxidase-like
(POD-like)
activity,
catalysing
conversion
endogenous
hydrogen
peroxide
into
highly
toxic
hydroxyl
radicals
through
Fenton-like
reaction,
depleting
glutathione
(GSH),
promoting
reactive
oxygen
species
(ROS)
generation
mitochondria
endoplasmic
reticulum,
inducing
ferroptosis.
Additionally,
could
activate
cGAS-STING
signalling
pathway
promote
maturation
dendritic
cells
infiltration
activated
T
cells,
thus
tumor
immunogenic
death
(ICD).
Furthermore,
it
effective
T2-weighted
MRI
enhancement
imaging,
making
them
valuable
diagnosis.
In
vitro
vivo
experiments
demonstrated
NPs
enabled
non-invasive
imaging
treatment,
presented
one-stone-for-two-birds
strategy
combining
with
broad
potential
application
therapy.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(7)
Published: Feb. 1, 2025
Abstract
A
multifunctional
isoniazid‐sugar–triazole
based
Schiff‐bases
were
designed
and
synthesized,
their
sensing
capability
was
studied
with
various
metal
ions
by
colorimetric,
absorption,
spectrofluorometric
techniques.
Interestingly,
the
molecule
processing
diethylamine
moiety
(
11
)
shows
fluorescent
“turn‐on”
chemosensor
properties
in
presence
of
Zn
2+
Mn
.
The
limit
detection
(LOD)
values
toward
respective
3.37
µM
1.46
µM,
a
1:2
stoichiometric
ratio,
respectively.
Compound
successfully
applied
to
effectively
detect
2
⁺
real
water
samples.
Additionally,
logic
gate
constructed,
where
fluorescence
intensity
served
as
output
signal,
responding
chemical
species
inputs.
Synthesized
compounds
screened
for
antibacterial
activities
against
panel
pathogenic
bacteria,
such
Staphylococcus
aureus,
Streptococcus
pyogenes
,
E.
coli
All
showed
significant
these
pathogens.
anticancer
activity
compound
13
investigated
human
osteosarcoma
(HOS)
cells.
MTT
assay
results
revealed
that
hybrid
sugar
derivative
exhibited
cytotoxicity
HOS
cell
line,
increased
potency
observed
at
concentration
60
µg/ml.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 21, 2025
Tumor
immunotherapy
aims
to
harness
the
immune
system
identify
and
eliminate
cancer
cells.
However,
its
full
potential
is
hindered
by
immunosuppressive
nature
of
tumors.
Radiotherapy
remains
a
key
treatment
modality
for
local
tumor
control
immunomodulation
within
microenvironment.
Yet,
efficacy
radiotherapy
often
limited
radiosensitivity,
traditional
radiosensitizers
have
shown
effectiveness
in
hepatocellular
carcinoma
(HCC).
To
address
these
challenges,
we
developed
novel
multifunctional
nanoparticle
system,
ZIF-8@MnCO@DOX
(ZMD),
designed
enhance
drug
delivery
tissues.
In
microenvironment,
Zn²⁺
Mn²⁺
ions
released
from
ZMD
participate
Fenton-like
reaction,
generating
reactive
oxygen
species
(ROS)
that
promote
cell
death
improve
radiosensitivity.
Additionally,
release
doxorubicin
(DOX)-an
anthracycline
chemotherapeutic
agent-induces
DNA
damage
apoptosis
The
combined
action
metal
double-stranded
(dsDNA)
damaged
cells
synergistically
activates
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway,
thereby
initiating
robust
anti-tumor
response.
Both
vitro
vivo
experiments
demonstrated
effectively
cGAS-STING
promotes
responses,
exerts
potent
tumor-killing
effect
combination
with
radiotherapy,
leading
regression
both
primary
tumors
distant
metastases.
Our
work
provides
straightforward,
safe,
effective
strategy
combining
treat
advanced
cancer.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(6), P. 944 - 944
Published: March 8, 2025
Background/Objectives:
Copper
(Cu)
and
zinc
(Zn)
are
essential
trace
elements,
an
imbalance
in
their
levels
may
influence
the
progression
of
cancer.
The
role
Cu
Zn
blood
serum,
as
well
10-year
survival
rates
kidney
cancer
patients,
remains
unclear.
Our
objective
was
to
determine
association
between
these
micronutrients
mortality
patients.
In
this
prospective
study,
we
examined
284
consecutive,
unselected
patients
assessed
relation
levels.
Methods:
Micronutrient
were
measured
using
inductively
coupled
plasma
mass
spectrometer.
Each
patient
categorized
into
one
four
groups
based
on
distribution
levels,
ranked
increasing
order.
multivariable
models
included
factors
such
age
at
diagnosis,
gender,
smoking
history,
type
surgery,
histopathological
results.
Results:
We
observed
a
significantly
higher
risk
all-cause
with
highest
or
serum
copper
compared
those
lower
(blood:
HR
=
4.89;
p
<
0.001;
serum:
3.75;
0.001).
With
regard
zinc,
found
trend
where
(I
quartile)
associated
mortality.
Additionally,
identified
significant
correlation
Zn/Cu
ratio
Conclusions:
Patients
lowest
quartile
had
elevated
hazard
ratios
HRs
3.05
(p
0.002)
5.72
0.001)
serum.
To
our
knowledge,
study
is
first
investigate
relationship
survival.
Inorganics,
Journal Year:
2025,
Volume and Issue:
13(4), P. 124 - 124
Published: April 17, 2025
Zinc
is
an
essential
trace
metal
element
in
the
human
body,
but
it
also
constitutes
a
variety
of
proteins
body
important
elements
necessary;
this
plays
role
physiological
metabolism.
Disturbances
metabolism
zinc
ions
can
significantly
threaten
health,
especially
neurological
diseases.
Therefore,
developing
rapid
and
straightforward
method
for
determining
important.
Fluorescent
probe
technology
has
been
widely
used
detecting
labeling
ions.
Among
many
fluorescent
probes,
rhodamine
derivative
LPDQ
unique
application
scenarios,
example,
detection
white
oil
colors,
its
advantages
are
simplicity,
rapidity,
real-time
operation.
This
paper
introduces
types
probes
three
main
mechanisms
detection.
The
characteristics,
design
strategies,
effects
ions,
as
well
their
limitations,
reviewed
summarized,
which
intended
to
provide
valuable
references
development
new
future
direction
research
field.
