The gender and age perspectives of allostatic load DOI Creative Commons
Nikola Volarić, Dunja Šojat,

Mile Volarić

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 17, 2024

The role of chronic stress in the development diseases, especially multimorbidity, through pathways increasing allostatic load, and finally, overload (the state when a compensatory mechanism is likely to fail) being emphasized. However, load dynamic measure that changes depending on sex, gender, age, level type stress, experience stressful situation, coping behaviors. Many other factors such as race, ethnicity, working environment, lifestyle, circadian rhythm sleep are also important. aim this paper was synthesize available information differences, those connected sex/gender provide model for future study with focus these differences. By carefully studying factors, we realized many studies do not take difference into account analysis methods. In paper, support idea further research develop new strategies will include all knowledge about differences will, more detail, explain numerous changeable social educational currently accepted biological ones. Furthermore, specific biomarkers expressed differently different age groups, indicating discrepancies cannot be attributed solely disparities. This kind approach can valuable, only better explaining frequency onset diseases but potential planning preventive actions based aforementioned disaparities, order prevent most frequent establish biomarker cut-off values each group.

Language: Английский

The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases DOI Open Access
Izabella Ryguła, Wojciech Pikiewicz, Beniamin Oskar Grabarek

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1984 - 1984

Published: Feb. 6, 2024

Dermatoses are an increasingly common problem, particularly in developed countries. The causes of this phenomenon include genetic factors and environmental elements. More more scientific reports suggest that the gut microbiome, specifically its dysbiosis, also plays important role induction progression diseases, including dermatological diseases. microbiome is recognised as largest endocrine organ, has a key function maintaining human homeostasis. In review, authors will take close look at link between gut-skin axis pathogenesis dermatoses such atopic dermatitis, psoriasis, alopecia areata, acne. focus on probiotics remodelling alleviation dermatoses.

Language: Английский

Citations

15
Effects of Physical Exercise on the Microbiota in Irritable Bowel Syndrome DOI Open Access
Chunpeng Li, Jianmin Li,

Qiaorui Zhou

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2657 - 2657

Published: Aug. 11, 2024

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain, bloating, diarrhea, and constipation. Recent studies have underscored the significant role of gut microbiota in pathogenesis IBS. Physical exercise, as non-pharmacological intervention, has been proposed to alleviate IBS symptoms modulating microbiota. Aerobic such running, swimming, cycling, shown enhance diversity abundance beneficial bacteria, including Lactobacillus Bifidobacterium. These bacteria produce short-chain fatty acids that possess anti-inflammatory properties support barrier integrity. Studies involving patients participating structured aerobic exercise programs reported improvements their microbiota's composition diversity, alongside an alleviation like pain bloating. Additionally, positively influences mental health reducing stress improving mood, which can further relieve via gut-brain axis. Long-term interventions provide sustained benefits, maintaining stability, supporting immune functions, systemic inflammation. However, must be tailored individual needs avoid exacerbating symptoms. Personalized plans starting with low-to-moderate intensity gradually increasing maximize benefits minimize risks. This review examines impact various types intensities physical on patients, highlighting need for explore optimal protocols. Future research should include larger sample sizes, longer follow-up periods, examine synergistic effects other lifestyle modifications. Integrating into comprehensive management symptom control improve patients' quality life.

Language: Английский

Citations

9
Effects of Exercise Intervention for the Management of Delirium in Hospitalized Older Adults: A Randomized Clinical Trial DOI
Lucía Lozano-Vicario, Fabíola Zambom-Ferraresi, Fabrício Zambom-Ferraresi

et al.

Journal of the American Medical Directors Association, Journal Year: 2024, Volume and Issue: 25(8), P. 104980 - 104980

Published: April 7, 2024

Language: Английский

Citations

8
Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives DOI Open Access
Ahmed Noor Eddin,

Mohammed Alfuwais,

Reena Noor Eddin

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 590 - 590

Published: Feb. 21, 2024

Amyotrophic Lateral Sclerosis (ALS) is a highly fatal neurodegenerative disorder characterized by the progressive wasting and paralysis of voluntary muscle. Despite extensive research, etiology ALS remains elusive, effective treatment options are limited. However, recent evidence implicates gut dysbiosis gut-brain axis (GBA) dysfunction in pathogenesis. Alterations to composition diversity microbial communities within flora have been consistently observed patients. These changes often correlated with disease progression patient outcome, suggesting that GBA modulation may therapeutic potential. Indeed, targeting microbiota has shown be neuroprotective several animal models, alleviating motor symptoms mitigating progression. translation these findings human patients challenging due complexity pathology varying microbiota. This review comprehensively summarizes current literature on ALS-related dysbiosis, focusing implications dysfunction. It delineates three main mechanisms which contributes pathology: compromised intestinal barrier integrity, metabolic dysfunction, immune dysregulation. also examines preclinical potential gut-microbiota-modulating agents (categorized as prebiotics, probiotics, postbiotics) ALS.

Language: Английский

Citations

7
Applied physiology: gut microbiota and antimicrobial therapy DOI
Andrey V. Suslov, Alin Panas, Mikhail Y. Sinelnikov

et al.

European Journal of Applied Physiology, Journal Year: 2024, Volume and Issue: 124(6), P. 1631 - 1643

Published: April 29, 2024

Language: Английский

Citations

4
Symphony of the gut microbiota and endocannabinoidome: a molecular and functional perspective DOI Creative Commons
Yang Wang, Jiafu Ji,

Zhuqing Mao

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 26, 2025

This review examines the impact of interactions between gut microbiota and endocannabinoidome (eCBome) on health disease, highlighting their significance for physiological pathological processes. We identify key research gaps challenges to advance field. The discusses role dietary patterns physical activity in regulating these interactions. It also explores complex nature conditions such as inflammatory bowel disease (IBD), depression, anxiety, Alzheimer’s (AD), metabolic disorders. analysis evaluates contributions onset progression, molecular mechanisms signaling pathways involved. From this, we provide forward-looking perspectives future directions, advocating a more nuanced understanding microbiota–eCBome axis. anticipate that will integrate microbiota–endocannabinoidome into therapeutic strategies broad range diseases.

Language: Английский

Citations

0
The role of resistance exercise-induced local metabolic stress in mediating systemic health and functional adaptations: could condensed training volume unlock greater benefits beyond time efficiency? DOI Creative Commons
Ivan Čurović

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

The majority of “specialised” exercise configurations (e.g., supersets, drop sets, blood flow restriction) are being assessed as “shortcuts” to hypertrophy and strength improvements. However, these advanced training techniques may also offer significant benefits for systemic health functional outcomes across recreational clinical populations via locally induced metabolic responses. Stress-regulating mechanisms known enhance the body’s resilience by facilitating allostasis, process coordinating adaptive processes in reaction stressors such physical training. Yet, role local stress provoked resistance has not gained much research attention despite its wide potential. Positive effects only linked improved muscular endurance, primary secondary mechanisms, but release myokines, hormones, microRNAs, immune factors, inflammatory substances other endocrine molecules that initiate numerous health-promoting modifications on a level. Resistance strategies maximise accumulation metabolites well defined, although high volume, close proximity failure shorter rests seem be necessity. Additionally, restriction provides potent alternative inducing acidosis, thereby triggering several pathways associated with immunity function even remote muscle tissues. Future is warranted further explore techniques, approaches comparable mental those seen forms high-intensity interval heavy

Language: Английский

Citations

0
Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review DOI Creative Commons

Alexandra K. Mitchell,

Rebecca R. Bliss,

Frank Church

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1241 - 1241

Published: Sept. 30, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative in which treatment often includes an exercise regimen. Exercise neuroprotective animal models of PD, and, more recently, human clinical studies have verified exercise's disease-modifying effect. Aerobic and resistance training improve many PD's motor non-motor symptoms, while neuromotor therapy stretching/flexibility exercises positively contribute to the quality life people with PD. Therefore, understanding role managing this complex disorder crucial. Exerkines are bioactive substances that synthesized released during been implicated several positive health outcomes, including neuroprotection. protect neuronal cells vitro rodent PD vivo. both increase exerkine levels blood, suggesting for exerkines theory. Many demonstrate potential protecting brain against pathological missteps caused by Every person (people) (PwP) needs comprehensive plan tailored their unique abilities. Here, we provide template help PwP understand importance treating describe barriers confronting attempt exercise, suggestions overcoming these barriers, explore In conclusion, together create powerful system should slowing chronic progression

Language: Английский

Citations

3
Ligilactobacillus Salivarius improve body growth and anti-oxidation capacity of broiler chickens via regulation of the microbiota-gut-brain axis DOI Creative Commons
Jiajun Yang, Jing Wang,

Zongliang Liu

et al.

BMC Microbiology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 9, 2023

Certain strains of probiotic bacteria can secret functional substances namely digestive enzymes and peptides to regulate physiological conditions such as digestion anti-oxidation, which are often incorporated in industrial broiler chick production. However, few studies have detailed the action mechanisms effects these on regulating growth anti-oxidation levels chickens. Ligilactobacillus salivarius is a strain used dietary supplement. In present study, was evaluated for its secreted vitro. To evaluate gastrointestinal tract (GIT) microbiota alleviating chickens through gut-brain axis. cultured supplemented food broilers effect by modulation gut microbial composition metabolites using metagenomic metabolomic assays. Biochemical results showed that enzymes: protease, lipase, amylase. Broiler with 42 days, increased body weights, reduced oxidative status, decreased malondialdehyde levels, improved activities rates total superoxide dismutase, glutathione peroxidase IIand IV improved. The caecum more abundant than those without probiotics supplementation, owing 400 number (489) bacterial operational taxonomic units (OTU). genera Lactobacillus, Megamonas, Ruminoccoccaceae, Ruminococcus, Alistipes Helicobacter shared dominant proportion Candidatus _Arthromitus compared control These assisted transportation amino acids, carbohydrates, ions, synthesis cellular membranes, anti-oxidation. Uncultured_organism_g_ Anaerosporobacter, Lactobacillus salivarius, uncultured_bacterium_g_ Ruminococcaceae_UCG-014, Peptococcus were strongly positively correlated performance A metabonomic assay suggested gamma-aminobutyric acid monobactam metabolized according Kyoto Encyclopedia Genes Genomes analysis. conclusion, optimized axis improve antioxidation chicken.

Language: Английский

Citations

8
Revitalizing the Gut Microbiome in Chronic Kidney Disease: A Comprehensive Exploration of the Therapeutic Potential of Physical Activity DOI Creative Commons
Marieke Vandecruys, Stefan De Smet, Jasmine De Beir

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(6), P. 242 - 242

Published: May 26, 2024

Both physical inactivity and disruptions in the gut microbiome appear to be prevalent patients with chronic kidney disease (CKD). Engaging activity could present a novel nonpharmacological strategy for enhancing mitigating adverse effects associated microbial dysbiosis individuals CKD. This narrative review explores underlying mechanisms through which may favorably modulate health, either direct impact on or interorgan crosstalk. Also, development of its interplay CKD are discussed. Mechanisms interventions restore homeostasis explored.

Language: Английский

Citations

2