Spike protein-related proteinopathies: a focus on the neurological side of spikeopathies

Annals of Anatomy - Anatomischer Anzeiger, Journal Year: 2025, Volume and Issue: unknown, P. 152662 - 152662

Published: April 1, 2025

Language: Английский

---

Apparent Cytotoxicity and Intrinsic Cytotoxicity of Lipid Nanomaterials Contained in a COVID-19 mRNA Vaccine

International Journal of Vaccine Theory Practice and Research, Journal Year: 2023, Volume and Issue: 3(1), P. 957 - 972

Published: Oct. 16, 2023

The medicinal preparation called Comirnaty by Pfizer-BioNTech is an aqueous dispersion of lipid nanomaterials, intended to constitute, after thawing and dilution, the finished product for intramuscular injection. In present study, we examine some evident chemical-physical criticalities preparation, particularly regarding apparent intrinsic pKa (acid dissociation constant) its main excipient, ionizable cationic ALC-0315. very high value causes, internalization endosomal escape LNPs, a sudden increase charge concentration consequently formation pro-inflammatory cytokines ROS (reactive oxygen species), that can disrupt mitochondrial membrane release content, cause RNA mistranslation, polymerization proteins DNA, DNA mutations, destruction nuclear consequent content. Additionally, apparently low (6.09) ALC-0315 associated with other lipids in LNP, not suitable application. Its too enable proper transfection host cells, despite what stated EMA (European Medicines Agency) Assessment report dated 19 February 2021, flagrant contradiction same bibliographic source therein cited. Furthermore, exceptional penetrability, mobility, chemical reactivity systemic accumulation uncontrollable nanoparticles, cytotoxicity levels, shed unpredictable biological locations, even far from site inoculation, are all factors lead unprecedented medical disaster. Meanwhile, further immediate studies verifications recommended, taking into consideration, accordance precautionary principle, suspension vaccinations COVID-19 mRNA- LNP-based vaccines.

Language: Английский

---

Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology

Endocrine and Metabolic Science, Journal Year: 2024, Volume and Issue: 14, P. 100163 - 100163

Published: Jan. 30, 2024

Fasting, a practice with historical roots in various cultures, has recently garnered significant interest the field of medicine. In this article, we delve into mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore potential fasting on protein-related pathology role interventions to upregulate autophagy, including compounds like spermidine, resveratrol, rapamycin, metformin. conclusion, fasting, coupled an understanding nuances, holds promise as intervention SARS-CoV-2 related diseases; broad implications human health. This review presents possibility using treat diseases, details deploy modality.

Language: Английский

---

Excess Cardiopulmonary Arrest and Mortality after COVID-19 Vaccination in King County, Washington

Published: May 27, 2024

Background: Since the onset of widespread COVID-19 vaccination campaigns, there have been concerns about serious cardiovascular adverse events, including myocarditis, myocardial infarction, and venous thromboembolisms, all which can lead to cardiopulmonary arrest. This study aimed estimate excess arrest mortality in King County, WA, investigate any association with rates. Methods: Data was obtained from annual EMS reports, U.S. Census Bureau, The Tennessean Vaccine Tracker. An exploratory data analysis performed. Excess deaths were calculated using 2015-2020 trend line. relationship between rates analyzed polynomial regression analysis. A quadratic model used generate expected population growth trends. for County calculate yearly estimates fatalities USA. Results: Approximately 98% received at least one dose a vaccine by 2023. Our revealed 25.7% increase total arrests 25.4% 2020 2023 WA. estimated increased 1,236% 2023, rising 11 (95% CI: -12, 34) 147 123, 170) observed higher general sharply declined 0.94% (21,300) 2021, deviating size. Applying our these entire United States yielded 49,240 fatal 2021-2023. Conclusions: We identified very strong ecological temporal campaign, resulted high biological plausibility death acute cardiac pulmonary causes after has previously demonstrated is concerning given real-world observations. Urgent further research needed determine if similar trends are other regions attention risk mitigation incident events improved survival resuscitation.

Language: Английский

---

Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook

Seminars in Thrombosis and Hemostasis, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Long coronavirus disease 2019 (COVID-19)—a postacute consequence of severe acute respiratory syndrome 2 infection—manifests with a broad spectrum relapsing and remitting or persistent symptoms as well varied levels organ damage, which may be asymptomatic present events such heart attacks strokes recurrent infections, hinting at complex underlying pathogenic mechanisms. Central to these is vascular dysfunction rooted in thrombotic endothelialitis. We review the scientific evidence that widespread endothelial (ED) leads chronic symptomatology. briefly examine molecular pathways contributing pathology provide detailed analysis how cellular processes underpin clinical picture. Noninvasive diagnostic techniques, flow-mediated dilation peripheral arterial tonometry, are evaluated for their utility identifying ED. then explore mechanistic, cellular-targeted therapeutic interventions potential treating Overall, we emphasize critical role health managing COVID highlight need early intervention prevent long-term dysfunction.

Language: Английский

---

Delayed Fatal Pulmonary Hemorrhage Following COVID-19 Vaccination: Case Report, Batch Analysis, And Proposed Autopsy Checklist

Published: Feb. 20, 2024

We present a case of 47-year-old male who died unexpectedly from acute pulmonary hemorrhage 555 days after completing the BNT162b2 (Pfizer) COVID-19 vaccination primary series. Before death, he exhibited symptoms mild respiratory infection. Despite healthy medical history and no medication use, patient’s condition rapidly deteriorated experienced severe distress, followed by cardiopulmonary arrest with evidence profuse bleeding. Autopsy findings revealed massive lung congestion without embolism, normal heart size, moderate coronary atherosclerosis myocardial infarction, other hemorrhagic events. The patient tested negative for pathogens at autopsy. these findings, examiner determined cause death was attributed to atherosclerotic hypertensive cardiovascular disease, considering recent unremarkable history. Investigation into vaccine batch indicated higher-than-average number serious adverse events, including fatalities. patient's among top 2.8% reported deaths. Moreover, autopsy failed investigate potential contributions vaccine, such as presence Spike protein or related antibodies. suggests that hemorrhage, exacerbated viral infection, immediate potentially playing role in development pathology hemorrhage. propose protocols recipients better vaccine-related pathologies those one more prior injections.

Language: Английский

---

Systematic Review of Individual Patient Data COVID-19 Infection and Vaccination–Associated Thrombotic Microangiopathy

Kidney International Reports, Journal Year: 2024, Volume and Issue: 9(11), P. 3134 - 3144

Published: Aug. 8, 2024

IntroductionSporadic cases of atypical hemolytic uremic syndrome (aHUS) have been described in the literature association with COVID-19 infection and vaccination adults pediatric patients. The exact mechanisms underlying COVID-19–associated thrombotic microangiopathies (TMAs) remain incompletely understood. Herein, we present a detailed meta-analysis clinical characteristics, outcomes, management strategies aHUS thrombocytopenic purpura (TTP).MethodsThis study was performed following Preferred Reporting Items for Systematic Reviews Meta-analyses updated guidelines. PubMed utilized searching case reports series. Adverse outcome at last follow-up defined as estimated glomerular filtration rate < 30 ml/min per 1.73 m2 (patients aHUS), no remission therapy, or patient death. Data were analyzed using Wilcoxon rank Chi-square tests.ResultsOur analysis cohort included 118 studies reporting on 170 These 84 86 TTP resulting from (n = 92) 78). Significantly more reported after 65) than immunization 19), compared to TTP, where reverse true 27 n 59, respectively; P 0.001). In patients stage 3 acute kidney injury (AKI), requirement replacement therapy (KRT) seen three-fourths median 15. severe (P 0.04) predicted nonremission death follow-up. Administration i.v., rituximab caplacizumab protective 0.03 0.06, respectively). Immune (iTTP) often HUS mRNA vaccines (81% vs. 58%; 0.06).ConclusionCOVID-19 are potential trigger onset relapse especially who not maintenance complement inhibitors immunosuppression.

Language: Английский

---

COVID-19 mortality paradox (United States vs Africa): Mass vaccination vs early treatment

World Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 19, 2024

The coronavirus disease 2019 (COVID-19) mortality rate in 55 African countries is almost 4.5 times lower than the despite Africa having over 4.2 more people. This paradox also evident when comparing Nigeria, a heavily populated, poorly vaccinated and weakly mandated country to Israel, small, highly strictly country. Nigeria has 4 COVID Israel. In this Field of Vision perspective, I explain how evolved drawing upon my academic, clinical social experience. Since April 2020, I’ve developed been using Egyptian immune-modulatory Kelleni’s protocol manage COVID-19 patients including pediatric, geriatric, pregnant, immune-compromised other individuals suffering from multiple comorbidities. It’s unfortunate that severe acute respiratory syndrome 2 still evolving accompanied by deaths. However Africa, we’ve able live without anxiety or mandates throughout pandemic because we trust science adopted early treatment safe, effective repurposed drugs have saved majority patients. article represents an tale honor.

Language: Английский

---

COVID-19 Modified mRNA “Vaccines”: Lessons Learned from Clinical Trials, Mass Vaccination, and the Bio-Pharmaceutical Complex, Part 2

International Journal of Vaccine Theory Practice and Research, Journal Year: 2024, Volume and Issue: 3(2), P. 1275 - 1344

Published: Aug. 16, 2024

The COVID-19 modified mRNA (modmRNA) lipid nanoparticle-based “vaccines” are not classical antigen-based vaccines but instead prodrugs informed by gene therapy technology. Of considerable note, these products have been linked to atypical adverse and serious event profiles. As discussed in Part 1, health-related risks drawbacks were drastically misreported underreported the Pfizer Moderna trial evaluations of genetic products. Now 2, we examine main structural functional aspects injectables. modmRNA injectable introduce a unique set biological challenges human body with potential induce an extensive range adverse, crippling, life-threatening effects. Based on fact that there is no current method quantify host (cell-based) spike protein production vivo following injection prodrugs, standard “dose”. This part due differences output, which depends cell metabolism transfection efficiency. It therefore difficult predict profiles individual basis, considering millions adults across world reported severe events context products, valid concerns raised regarding infants younger age groups for whom poses only minimal risks. We address process-related impurities inherent mass posed contaminants. then categorize principal associated brief systems-based synopsis each six domains harms: (1) cardiovascular, (2) neurological, (3) hematologic; (4) immunological, (5) oncological, (6) reproductive. conclude discussion primary public health regulatory issues arising from this evidence-informed synthesis literature reiterate urgency imposing global moratorium modmRNA-LNP-based platform.

Language: Английский

---

Pharmaceutical product recall and educated hesitancy towards new drugs and novel vaccines

International Journal of Risk & Safety in Medicine, Journal Year: 2024, Volume and Issue: 35(4), P. 317 - 333

Published: Nov. 1, 2024

Background: Of many pharmaceutical products launched for the benefit of humanity, a significant number have had to be recalled from marketplace due adverse events. A systematic review found market recalls 462 between 1953 and 2013. In our current remarkable period medical history, excess mortality figures are high in countries. Yet these statistics receive limited attention, often ignored or dismissed by mainstream news outlets. This may include effects caused novel agents that use gene-code technology. Objective: To examine key product withdrawals derive lessons inform gene-based COVID-19 vaccines. Methods: Selective narrative historical comparative issues with recent Results: Parallels past drug vaccines distortion clinical trial data, critical event data absent high-impact journal publications. Delayed regulatory action on pharmacovigilance trigger withdrawal occurred Vioxx (rofecoxib) is apparent Conclusion: Public health requires access raw improved transparency corporations heightened, active worldwide.

Language: Английский

---