Association between cardiovascular health and metabolic dysfunction-associated steatotic liver disease: a nationwide cross-sectional study

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 13, 2025

Evidence concerning the effect of cardiovascular health (CVH) on risk metabolic dysfunctional-associated steatotic liver disease (MASLD) is scarce. This study aimed to investigate association between CVH and MASLD. 5680 adults aged ≥ 20 years from National Health Nutrition Examination Survey 2017-March 2020 were included. Life's essential 8 (LE8) was applied assess CVH. Weighted binary logistic regression employed calculate odds ratio (OR) 95% confidence interval (CI) with Restricted cubic spline (RCS) conducted explore dose-response LE8 its subscales scores Among participants, 724, 3901, 1055 had low, moderate, high levels, respectively, a MASLD diagnosis prevalence 36.83%. In fully adjusted model, ORs for 0.50 (95% CI, 0.37–0.69) participants moderate 0.21 0.13–0.34) those CVH, when compared low (P < 0.001 trend). OR 0.68 0.61–0.77) each 10-point increase in score. RCS model demonstrated non-linear relationship score factors MASLD, while linear found behaviors Subgroup analysis showed consistent negative correlation sensitivity validated reliability these findings. Higher associated lower Encouraging adherence optimal levels may help mitigate burden

Language: Английский

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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease

Annals of Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 101777 - 101777

Published: Jan. 1, 2025

Non-alcoholic fatty liver disease (NAFLD), now recognized as metabolic dysfunction-associated steatotic (MASLD), represents a significant and escalating global health challenge. Its prevalence is intricately linked to obesity, insulin resistance, other components of the syndrome. As our comprehension MASLD deepens, it has become evident that this condition extends beyond liver, embodying complex, multi-systemic with hepatic manifestations mirror broader landscape. This comprehensive review delves into critical interplay between gut-liver axis oxidative stress, elucidating their pivotal roles in etiology progression MASLD. Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger stress through enhanced ROS production hepatocytes Kupffer cells, leading mitochondrial dysfunction lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation endotoxins like LPS, which activate inflammatory pathways TLR4 signaling promote via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB Nrf2 serve crucial mediators axis, regulating responses orchestrating antioxidant defenses; (4) Oxidative stress-induced damage function creates destructive feedback loop, further exacerbating inflammation progression. These findings highlight complex interrelationship pathogenesis, suggesting potential therapeutic targets for management.

Language: Английский

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Cutting-edge biotherapeutics and advanced delivery strategies for the treatment of metabolic dysfunction-associated steatotic liver disease spectrum

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 433 - 456

Published: Feb. 11, 2025

Language: Английский

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Inflammatory Response in the Pathogenesis and Treatment of Hepatocellular Carcinoma: A Double-Edged Weapon

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7191 - 7191

Published: June 29, 2024

Hepatocellular carcinoma (HCC) is the most frequent among primary liver tumors (90%) and one of main causes cancer-related death. It develops usually in a chronically inflamed environment, ranging from compensatory parenchymal regeneration to fibrosis cirrhosis: carcinogenesis can potentially happen each these stages. Inflammation determined by chronic viral infection (hepatitis B, hepatitis C, delta viruses) represents an important risk factor for HCC etiology through both direct damage immune-related mechanisms. The deregulation physiological immunological network lead carcinogenesis. recent introduction immunotherapy as gold-standard first-line treatment highlights role immune system inflammation double-edged weapon treatment. In this review we highlight how key hepatocarcinogenesis viral, alcohol metabolic diseases.

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4243 - 4243

Published: July 20, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) are prevalent conditions that have been correlated with infertility through overlapped pathophysiological mechanisms. MASLD is associated metabolic considered among the major causes of chronic disease, while PCOS, which characterized by ovulatory dysfunction hyperandrogenism, one leading female infertility. The links between PCOS not yet fully elucidated, insulin resistance, hyperandrogenemia, obesity, dyslipidemia being key pathways contribute to lipid accumulation, inflammation, fibrosis, aggravating dysfunction. On other hand, exacerbates resistance dysregulation in women creating a vicious cycle progression. Understanding intricate relationship crucial improving clinical management, collaborative efforts different medical specialties essential optimize fertility health outcomes individuals PCOS. In this review, we summarize complex interplay highlighting importance increasing attention prevention, diagnosis, treatment both entities.

Language: Английский

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Hepatic Iron Overload and Hepatocellular Carcinoma: New Insights into Pathophysiological Mechanisms and Therapeutic Approaches

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 392 - 392

Published: Jan. 24, 2025

Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is rising in global incidence and mortality. Metabolic dysfunction-associated steatotic disease (MASLD), one leading causes chronic disease, strongly linked to metabolic conditions that can progress cirrhosis HCC. Iron overload (IO), whether inherited or acquired, results abnormal iron hepatic deposition, significantly impacting MASLD development progression While pathophysiological connections between IO, MASLD, HCC are not fully understood, dysregulation glucose lipid metabolism IO-induced oxidative stress being investigated as drivers. Genomic analyses IO reveal inconsistencies association certain mutations with malignancies. Moreover, also associated hepcidin activation ferroptosis, representing promising targets for risk assessment therapeutic intervention. Understanding relationship essential advancing clinical strategies against progression, particularly recent IO-targeted therapies showing potential at improving biochemistry insulin sensitivity. In this review, we summarize current evidence on HCC, underscoring importance early diagnosis, stratification, targeted treatment these interconnected conditions.

Language: Английский

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Feasibility of Serum Galectin-1 as a Diagnostic Biomarker for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Study on a Segment of the Chinese Population Using Convenience Sampling

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 425 - 425

Published: Feb. 10, 2025

Background/Objectives: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is commonly considered as a hepatic manifestation of metabolic syndrome, posing considerable public health and economic challenges due to its high prevalence. This study investigates the diagnostic potential serum galectin-1 levels in MASLD patients. Methods: A total 128 participants were analyzed for this study, comprising 68 healthy controls 60 The steatosis index (HSI) fatty liver (FLI) calculated evaluate steatosis. Serum measured using an enzyme-linked immunosorbent assay. We additionally conducted comparative analysis mRNA protein expression tissue between mouse models MASLD, including ob/ob mice (n = 6), high-fat diet-fed C57 control group 6). Results: Average significantly differed groups, with lower values (p < 0.01). frequency increased higher quartiles correlation showed positive relationship both HSI FLI multivariate logistic regression indicated that elevated was associated risk 0.01), yielding area under receiver operating characteristic curve predicting at 0.745 (95% CI: 0.662-0.829). Hepatic also model transcript Conclusions: can be used biomarker help diagnose MASLD.

Language: Английский

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Therapeutic Potential and Mechanisms of Puerarin in Liver Disease: A Comprehensive Review of Pharmacological Effects and Drug Delivery Innovations

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100594 - 100594

Published: Feb. 1, 2025

Language: Английский

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Significance of FXR agonists in MASLD treatment: a deep dive into lipid alteration by analytical techniques

Published: March 25, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly emerging as a global health crisis, affecting over 30% of the population and demanding urgent attention. This redefined condition, previously known non-alcoholic fatty (NAFLD), reflects deeper understanding intricate interplay between metabolic dysfunction health. At heart MASLD lies troubling accumulation triglycerides (TGs) in hepatocytes, which precipitates insulin resistance oxidative stress, ultimately leading to more severe forms like steatohepatitis (MASH). Excitingly, recent research has spotlighted farnesoid X receptor (FXR) groundbreaking therapeutic target. FXR not only regulates lipid metabolism but also combats inflammation resistance, making it potential game-changer fight against MASLD. With one FDA-approved drug, resmetirom, currently available, exploration agonists opens new avenues for innovative treatments that could revolutionize patient care. By harnessing power restore balance integrating advanced strategies lipidomics acid profiling, we stand on brink transforming how approach its associated complications, paving way healthier future. review delves into promising role combating implications related disorders, emphasizing urgency detect manage this burgeoning epidemic.

Language: Английский

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MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855

Published: April 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Language: Английский

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