PEDIATRIC ENTEROCOLITIS: CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES DOI Creative Commons
Cristina Maria Mihai, Lorenza Forna, Ginel Baciu

et al.

Published: Dec. 20, 2024

Diarrhea is a leading cause of illness and death in children under five years old. Severe cases diarrhea, particularly those resulting dehydration, are major factor high mortality rates. Rotavirus significant pathogen contributing to dehydrating diarrhea hospitalizations five. The aim this study was investigate the role vaccination preventing progression gastroenteritis, with focus on rotavirus-induced gastroenteritis. Material methods: present conducted within Pediatric Department Emergency Clinical Hospital “St. Apostle Andrew” Constanța, including 307 patients diagnosed acute gastroenteritis during period January 1 December 31, 2023. Results: prevalence declined age: 183 infants, 67 were between 3 old, 42 aged 7, smallest group, 15 patients, 7 16 201 did not receive Rotarix or Rotateq vaccines, while 106 completed full regimen. As for etiology disease, 160 viral enterocolitis, 142 attributed Rotavirus. An increase dehydration electrolyte imbalances observed subjects who had received preventive vaccine. Conclusion: vaccine severe that caused by Rotavirus, highlighted reduced frequency imbalances, shorter hospital stays Rotarix/Rotateq

Language: Английский

Dysbiosis Signature of Fecal Microbiota in Patients with Pancreatic Adenocarcinoma and Pancreatic Intraductal Papillary Mucinous Neoplasms DOI Creative Commons
Theodoros Sidiropoulos, Nikolas Dovrolis, Hector Katifelis

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1040 - 1040

Published: May 8, 2024

Pancreatic cancer (PC) ranks as the seventh leading cause of cancer-related deaths, with approximately 500,000 new cases reported in 2020. Existing strategies for early PC detection primarily target individuals at high risk developing disease. Nevertheless, there is a pressing need to identify innovative clinical approaches and personalized treatments effective management. This study aimed explore dysbiosis signature fecal microbiota potential distinctions between its Intraductal papillary mucinous neoplasm (IPMN) pancreatic ductal adenocarcinoma (PDAC) phenotypes, which could carry diagnostic significance. The enrolled 33 participants, including 22 diagnosed PDAC, 11 IPMN, 24 healthy controls. Fecal samples were collected subjected microbial diversity analysis across various taxonomic levels. findings revealed elevated abundances Firmicutes Proteobacteria patients, whereas controls exhibited higher proportions Bacteroidota. Both LEfSe Random Forest analyses indicated microbiome’s effectively distinguish control but fell short differentiating IPMN PDAC samples. These results contribute current understanding this challenging type highlight applications microbiome research. In essence, provides clear evidence gut capability serve biomarker detection, emphasizing steps required further differentiation among diverse phenotypes.

Language: Английский

Citations

8
Celiac disease - a pluripathological model in pediatric practice DOI Creative Commons
Vasile Valeriu Lupu, Maria Oana Mărginean, Elena Jechel

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 23, 2024

Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially pediatrics, celiac disease (also called gluten enteropathy), is gaining more and ground terms of diagnosis, also interest research. The data from the literature last decades attest chameleonic way its presentation, there may be both classic onset symptoms atypical symptoms. Given impact played by disease, optimal growth development children, current narrative review aims to highlight presentation methods, intended guide clinician towards inclusion pathology differential diagnosis scheme. To these we add summary general therapeutic lines regarding underlying condition existing comorbidities. In order place related information up date, performed a recent articles published international databases. We bring forward theories approaches manifestations. Among note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, disorders biological constants association with multiple autoimmunities. Knowing correlating them key management patients, thus reducing subsequent burden disease.

Language: Английский

Citations

7
Is oxidative stress - antioxidants imbalance the physiopathogenic core in pediatric obesity? DOI Creative Commons

Ancuța Lupu,

Silvia Fotea,

Elena Jechel

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Despite the early recognition of obesity as an epidemic with global implications, research on its pathogenesis and therapeutic approach is still rise. The literature 21st century records excess weight found in up to 1/3 children. Both determining factors systemic effects are multiple variable. Regarding involvement potentiation cardio-vascular, pulmonary, digestive, metabolic, neuro-psychic or even dermatological diseases, information already broadly outlined. connection between underlying disease associated comorbidities seems be partially attributable oxidative stress. In addition these, light recent COVID-19 pandemic, role played by stress induction, maintenance chronic inflammation among overweight children adolescents becomes a topic interest again. Thus, this review’s purpose update general data obesity, emphasis physiopathological mechanisms that underlie it involve At same time, we briefly present latest principles pathology diagnosis management. Among will mainly emphasize impact endogenous exogenous antioxidants evolutionary course pediatric obesity. order achieve our objectives, refer most studies published specialized literature.

Language: Английский

Citations

7
Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline DOI Creative Commons
Vasile Valeriu Lupu, Ingrith Miron, Laura Mihaela Trandafir

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Diabetes is a complex condition with rising global incidence, and its impact equally evident in pediatric practice. Regardless of whether we are dealing type 1 or 2 diabetes, the development complications following onset disease inevitable. Consequently, contemporary medicine must concentrate on understanding pathophysiological mechanisms driving systemic decline finding ways to address them. We particularly interested effects oxidative stress target cells organs, such as pancreatic islets, retina, kidneys, neurological cardiovascular systems. Our goal explore, using latest data from international scientific databases, relationship between persistence damage associated diabetes children. Additionally, highlight beneficial roles antioxidants vitamins, minerals, polyphenols, other bioactive molecules; mitigating pathogenic cascade, detailing how they intervene their properties. As result, our study provides comprehensive exploration key aspects stress-antioxidants-pediatric triad, expanding significance various diseases.

Language: Английский

Citations

3
New Insights into Chronic Pancreatitis: Potential Mechanisms Related to Probiotics DOI Creative Commons
Yingyu Pan, Jianing Li,

Zhengyang Fan

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1760 - 1760

Published: Aug. 24, 2024

Chronic pancreatitis is a progressive fibroinflammatory disorder with no currently satisfactory treatment. Emerging evidence suggests an association between gut microbial dysbiosis and chronic pancreatitis. Although direct causative lacking, it hypothesized that the microbiota may play pivotal role in modulating pancreatic function via gut–pancreas axis. Thus, through administration of probiotics or prebiotics alleviate disorders. In this review, we first propose potential mechanisms by which specific ameliorate pancreatitis, including alleviation small intestinal bacterial overgrowth (SIBO), facilitation short-chain fatty acids’ (SCFAs) production, activation glucagon-like peptide-1 receptors (GLP-1Rs) pancreas. Since there are used for treatment discuss research other disease models have to modulate endocrine exocrine functions prevent fibrosis. This provides indirect their application We anticipate will stimulate further investigation into axis therapeutic value

Language: Английский

Citations

2
New Insights into Chronic Pancreatitis Treatment: Potential Mechanisms and Applications of Probiotics and Prebiotics DOI Open Access
Yingyu Pan, Jianing Li,

Zhengyang Fan

et al.

Published: Aug. 12, 2024

Chronic pancreatitis is a progressive fibroinflammatory disorder with no currently satisfactory treatment. Emerging evidence suggests an association between gut microbial dysbiosis and chronic pancreatitis. Although direct causative lacking, it hypothesized that the microbiota may play pivotal role in modulating pancreatic function via gut-pancreas axis. Thus, through administration of probiotics or prebiotics alleviate disorders. In this review, we first propose potential mechanisms by which specific ameliorate pancreatitis, including alleviation small intestinal bacterial overgrowth (SIBO), facilitation short-chain fatty acids (SCFAs) production, activation glucagon-like peptide 1 receptors (GLP-1Rs) pancreas. Since there are used for treatment have discussed research other disease models use to modulate endocrine exocrine functions prevent fibrosis. This provides indirect their application We anticipate will stimulate further investigation into axis therapeutic value

Language: Английский

Citations

1
Undercover lung damage in pediatrics - a hot spot in morbidity caused by collagenoses DOI Creative Commons

Ancuța Lupu,

Maria Oana Mărginean, Elena Jechel

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Connective tissue represents the support matrix and connection between tissues organs. In its composition, collagen, major structural protein, is main component of skin, bones, tendons ligaments. Especially at pediatric age, damage in context pathologies such as systemic lupus erythematosus, scleroderma or dermatomyositis can have a significant negative impact on development optimal functioning body. The consequences extend to various structures (e.g., joints, eyes, lungs, heart, kidneys). Of these, we retain reveal later our manuscript, mainly respiratory involvement. Manifested forms that chest wall, pleura, interstitium vascularization, lung inflammatory diseases underdeveloped literature compared described adults. Under threat severe evolution, sometimes rapidly progressive leading death, it necessary increase popularization information aimed physiopathological triggering maintenance mechanisms, diagnostic means, therapeutic directions among medical specialists. addition, emphasize need for interdisciplinary collaboration, especially pediatricians, rheumatologists, infectious disease specialists, pulmonologists, immunologists. Through narrative review bring up date, concise easy assimilate, general principles regarding pulmonary collagenoses using most recent articles published international libraries, duplicated by previous articles, reference targeted pathologies.

Language: Английский

Citations

0
Metabolic syndrome therapy in pediatric age — between classic and modern. From diets to pipeline drugs DOI Creative Commons
Otilia Elena Frăsinariu, Vasile Valeriu Lupu, Laura Mihaela Trandafir

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 11, 2024

The metabolic syndrome, made up of the sum entities that define it (obesity, hypertension, dyslipidemias and non-alcoholic hepatic steatosis) has gained an important place in research last decades. This aspect is mainly due to complexity management pediatric practice. main directions his approach therefore bring together concern counteracting noise or systemic, multiple intercurrents at physiopathological level, as well negative imprint exerted on quality life. Its appearance evolution are currently controversial topics, but influence genetic predisposition lifestyle (diet, physical activity, psychological balance) certainties. Considering escalation incident global self-evident necessary know pathogenesis practice countermeasures for prophylactic therapeutic purposes. present work aims summarize general aspects related syndrome encountered age, with emphasis complementary perspectives their effectiveness, by analyzing latest data from specialized literature, accessed help international databases (e.g., PubMed, Web Science, Scopus, Embase, Google Scholar).

Language: Английский

Citations

0
PEDIATRIC ENTEROCOLITIS: CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES DOI Creative Commons
Cristina Maria Mihai, Lorenza Forna, Ginel Baciu

et al.

Published: Dec. 20, 2024

Diarrhea is a leading cause of illness and death in children under five years old. Severe cases diarrhea, particularly those resulting dehydration, are major factor high mortality rates. Rotavirus significant pathogen contributing to dehydrating diarrhea hospitalizations five. The aim this study was investigate the role vaccination preventing progression gastroenteritis, with focus on rotavirus-induced gastroenteritis. Material methods: present conducted within Pediatric Department Emergency Clinical Hospital “St. Apostle Andrew” Constanța, including 307 patients diagnosed acute gastroenteritis during period January 1 December 31, 2023. Results: prevalence declined age: 183 infants, 67 were between 3 old, 42 aged 7, smallest group, 15 patients, 7 16 201 did not receive Rotarix or Rotateq vaccines, while 106 completed full regimen. As for etiology disease, 160 viral enterocolitis, 142 attributed Rotavirus. An increase dehydration electrolyte imbalances observed subjects who had received preventive vaccine. Conclusion: vaccine severe that caused by Rotavirus, highlighted reduced frequency imbalances, shorter hospital stays Rotarix/Rotateq

Language: Английский

Citations

0