International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113582 - 113582
Published: Nov. 12, 2024
Language: Английский
Prospects in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 23(1), P. 9 - 24
Published: Jan. 18, 2025
As the prevalence of sports-related injuries continues to rise, there is an urgent need for innovative therapeutic strategies that not only expedite recovery but also enhance quality healing. The application mesenchymal stromal cells (MSCs) therapy in treatment sports represents a groundbreaking advancement field regenerative medicine. This review aims summarize and discuss effects MSCs facilitating tissue regeneration expediting healing process following injuries. It highlight current research findings regarding efficacy, safety administration routes clinical trials. Data was obtained by searching Pubmed Google Scholar, using keywords: ‘sport injury, ‘Osteoarthritis’, ‘mesenchymal stromal/stem cells’, ‘tendon’, ‘cartilage defect’, ‘ligament injury’, ‘MSC secretome’, ‘conditioned medium’. According U. S. National Library Medicine, have been total 7,146 registered trials worldwide on stem cell till 5/10/2024, with 1,626 specifically focusing therapy. efficacy secretome therapies treating sport-related shown many preclinical studies. promising outcomes observed experimental studies propelled transition trials, which positive results. has potential accelerate processes, reduce downtime, allow athletes return their sport faster greater confidence. crucial professional recreational enthusiasts who seek maintain active lifestyle. However, bone marrow (BM-MSCs), umbilical cord (UCB-MSCs) adipose-derived (AD-MSCs) were predominantly utilized these indicating unexplored from other sources. contribute valuable knowledge field, aspires inspire further exploration innovation use enhancing athletic performance recovery.
Language: Английский
Citations
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Orthopädie und Unfallchirurgie up2date, Journal Year: 2025, Volume and Issue: 20(02), P. 153 - 175
Published: March 24, 2025
Sehnenverletzungen und -erkrankungen stellen häufige medizinische Behandlungsindikationen dar. Je nach Lokalisation verfügen Sehnen über einen spezifischen zum Teil äußerst komplexen Aufbau, der unterschiedlicher Behandlungsoptionen bedarf. Die Kenntnis anatomischen (patho-)physiologischen Grundlagen sowie zur Verfügung stehenden Therapieoptionen ist deshalb essenzielle Voraussetzung für eine erfolgreiche Behandlung.
Citations
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The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Abstract Tendon injuries are a common and significant health burden around the world. Current treatment strategies unable to fully restore tendon structure function. To address these critical clinical needs, stem cell therapy has recently emerged as promising approach for better repair. In this review, we discuss efficacy of in repair by summarizing its advantages disadvantages both preclinical settings. We highlight recent advances improving cell‐based treatment, with focus on research efforts identification appropriate sources, modification effective transplantation, development carriers, standardization protocols. Finally, provide insights into future directions therapy, emphasis necessity employing patient screening criteria before establishing comprehensive outcome measurements ensure rigor trials. image
Language: Английский
Citations
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Experimental Cell Research, Journal Year: 2024, Volume and Issue: 442(2), P. 114230 - 114230
Published: Aug. 31, 2024
Human periodontal ligament cells (hPDLCs) contain multipotent postnatal stem that can differentiate into PDL fibroblasts, osteoblasts, and cementoblasts. Interaction between the extracellular environment is an important factor for differentiation other progenitor cells. To identify cell surface molecules induce fibroblastic differentiation, we developed a series of monoclonal antibodies against membrane/ECM molecules. One these antibodies, anti-PDL25 antibody, recognizes approximately 100 kDa protein, this antigenic molecule accumulates in region tooth roots. By mass spectrometric analysis, found recognized by antibody fibroblast activation protein α (FAPα). The expression level FAPα/PDL25 increased TGF-β1-induced was localized boundaries elongated processes Ectopic FAPα induced differentiation. In contrast, representative markers decreased knock down blocking FAPα/PDL25. Inhibition dipeptidyl peptidase activity potent inhibitor dramatically inhibited marker but did not affect proliferation migration.
Language: Английский
Citations
1
Bioengineering, Journal Year: 2024, Volume and Issue: 11(10), P. 1019 - 1019
Published: Oct. 12, 2024
Tendons enable movement through their highly aligned extracellular matrix (ECM), predominantly composed of collagen I. Tendinopathies disrupt the structural integrity tendons by causing fragmentation fibers, disorganization fiber bundles, and an increase in glycosaminoglycans microvasculature, thereby driving apparent biomechanical regenerative capacity patients. Moreover, complex cellular communication within tendon microenvironment ultimately dictates fate between healthy diseased tendon, wherein vesicles (EVs) may facilitate tendon's transporting biomolecules tissue. In this study, we aimed to elucidate how EV functionality is altered context microenvironments using polycaprolactone (PCL) electrospun scaffolds mimicking pathological matrices. Scaffolds were characterized for alignment, mechanical properties, activity. EVs isolated analyzed concentration, heterogeneity, protein content. Our results show that our mimicked led secretion baseline metabolic activity over where reduced a significant 5 days observed. These findings suggest scaffold mechanics influence functionality, offering insights into homeostasis. Future research should further investigate cargo affects microenvironment.
Language: Английский
Citations
1
Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1939 - 1939
Published: July 7, 2024
Cryogels represent a valid strategy as scaffolds for tissue engineering. In order to adequately support adhesion and proliferation of anchorage-dependent cells, different polymers need be combined within the same scaffold trying mimic complex features natural extracellular matrix (ECM). For this reason, in work, gelatin (Gel) chondroitin sulfate (CS), both functionalized with methacrylic groups produce CSMA GelMA derivatives, were selected prepare cryogel networks. Both homopolymer heteropolymer cryogels produced, via radical crosslinking reactions carried out at −12 °C 2 h. All characterized their mechanical, swelling morphological properties, before after autoclave sterilization. Moreover, they evaluated biocompatibility ability human gingival fibroblasts tenocytes. GelMA-based networks better withstood sterilization process, compared cryogels. Indeed, showed decrease stiffness approximately 30%, whereas 80%. When blended network, an intermediate outcome was observed. However, hybrid general worsening biological performance. despite withstand limited modification mechanical exhibited poor cell high LDH leakage. Therefore, not only do network components properly selected, but also combination effective process should carefully development efficient designed engineering purposes.
Language: Английский
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Knee Surgery Sports Traumatology Arthroscopy, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 29, 2024
Language: Английский
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0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113582 - 113582
Published: Nov. 12, 2024
Language: Английский
Citations
0