International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12082 - 12082
Published: Nov. 11, 2024
Osteoarthritis
(OA)
is
a
chronic
progressive
disease
of
the
joint.
Although
representing
most
frequent
cause
disability
in
elderly,
OA
remains
partly
obscure
its
pathogenic
mechanisms
and
still
orphan
resolutive
therapies.
The
concept
what
was
once
considered
"wear
tear"
articular
cartilage
now
that
an
inflammation-related
affects
over
time
whole
attention
increasingly
focused
on
synovium.
Even
from
earliest
clinical
stages,
synovial
inflammation
(or
synovitis)
crucial
factor
involved
progression
major
player
pain
onset.
release
inflammatory
molecules
synovium
mediates
worsening
features.
activation
tissue-resident
cells
recalls
innate
immunity
bloodstream,
creating
proinflammatory
milieu
fuels
maintains
damaging
condition
low-grade
In
such
context,
cellular
molecular
behaviors
could
be
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 30, 2024
As
global
population
and
lifestyles
change,
osteoarthritis
(OA)
is
becoming
a
major
healthcare
challenge
world.
OA,
chronic
condition
characterized
by
inflammatory
degeneration,
often
present
with
joint
pain
can
lead
to
irreversible
disability.
While
there
currently
no
cure
for
it
commonly
managed
using
nonsteroidal
anti-inflammatory
drugs
(NSAIDs),
glucocorticoids,
glucosamine.
Although
these
treatments
alleviate
symptoms,
difficult
effectively
deliver
sustain
therapeutic
agents
within
joints.
The
emergence
of
nanotechnology,
particularly
in
form
smart
nanomedicine,
has
introduced
innovative
approaches
OA
treatment.
Nanotherapeutic
strategies
offer
promising
advantages,
including
more
precise
targeting
affected
areas,
prolonged
effects,
enhanced
bioavailability,
reduced
systemic
toxicity
compared
traditional
treatments.
nanoparticles
show
potential
as
viable
delivery
system
therapies
based
on
encouraging
lab-based
clinical
trials
results,
remails
considerable
gap
between
current
research
application.
This
review
highlights
recent
advances
nanotherapy
explore
future
pathways
refine
optimize
strategies.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 5, 2024
Observational
studies
have
indicated
a
potential
association
between
autoimmune
diseases
and
the
occurrence
of
Osteoarthritis
(OA),
with
an
increased
risk
mortality
among
affected
patients.
However,
whether
causal
relationship
exists
two
remains
unknown.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12082 - 12082
Published: Nov. 11, 2024
Osteoarthritis
(OA)
is
a
chronic
progressive
disease
of
the
joint.
Although
representing
most
frequent
cause
disability
in
elderly,
OA
remains
partly
obscure
its
pathogenic
mechanisms
and
still
orphan
resolutive
therapies.
The
concept
what
was
once
considered
"wear
tear"
articular
cartilage
now
that
an
inflammation-related
affects
over
time
whole
attention
increasingly
focused
on
synovium.
Even
from
earliest
clinical
stages,
synovial
inflammation
(or
synovitis)
crucial
factor
involved
progression
major
player
pain
onset.
release
inflammatory
molecules
synovium
mediates
worsening
features.
activation
tissue-resident
cells
recalls
innate
immunity
bloodstream,
creating
proinflammatory
milieu
fuels
maintains
damaging
condition
low-grade
In
such
context,
cellular
molecular
behaviors
could
be
